Photoacoustic microscopy of neovascularization in three-dimensional porous scaffolds
Publication
, Conference
Cai, X; Zhang, Y; Li, L; Choi, SW; MacEwan, MR; Yao, J; Kim, C; Xia, Y; Wang, LV
Published in: Progress in Biomedical Optics and Imaging - Proceedings of SPIE
May 28, 2013
It is a challenge to non-invasively visualize in vivo the neovascularization in a three-dimensional (3D) scaffold with high spatial resolution and deep penetration depth. Here we used photoacoustic microscopy (PAM) to chronically monitor neovascularization in an inverse opal scaffold implanted in a mouse model for up to six weeks. The neovasculature was observed to develop gradually in the same mouse. These blood vessels not only grew on top of the implanted scaffold but also penetrated into the scaffold. The PAM system offered a lateral resolution of ∼45 μm and a penetration depth of ∼3 mm into the scaffold/tissue construct. By using the 3D PAM data, we further quantified the vessel area as a function of time. © 2013 Copyright SPIE.
Duke Scholars
Published In
Progress in Biomedical Optics and Imaging - Proceedings of SPIE
DOI
ISSN
1605-7422
ISBN
9780819493507
Publication Date
May 28, 2013
Volume
8581
Citation
APA
Chicago
ICMJE
MLA
NLM
Cai, X., Zhang, Y., Li, L., Choi, S. W., MacEwan, M. R., Yao, J., … Wang, L. V. (2013). Photoacoustic microscopy of neovascularization in three-dimensional porous scaffolds. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 8581). https://doi.org/10.1117/12.2005236
Cai, X., Y. Zhang, L. Li, S. W. Choi, M. R. MacEwan, J. Yao, C. Kim, Y. Xia, and L. V. Wang. “Photoacoustic microscopy of neovascularization in three-dimensional porous scaffolds.” In Progress in Biomedical Optics and Imaging - Proceedings of SPIE, Vol. 8581, 2013. https://doi.org/10.1117/12.2005236.
Cai X, Zhang Y, Li L, Choi SW, MacEwan MR, Yao J, et al. Photoacoustic microscopy of neovascularization in three-dimensional porous scaffolds. In: Progress in Biomedical Optics and Imaging - Proceedings of SPIE. 2013.
Cai, X., et al. “Photoacoustic microscopy of neovascularization in three-dimensional porous scaffolds.” Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 8581, 2013. Scopus, doi:10.1117/12.2005236.
Cai X, Zhang Y, Li L, Choi SW, MacEwan MR, Yao J, Kim C, Xia Y, Wang LV. Photoacoustic microscopy of neovascularization in three-dimensional porous scaffolds. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. 2013.
Published In
Progress in Biomedical Optics and Imaging - Proceedings of SPIE
DOI
ISSN
1605-7422
ISBN
9780819493507
Publication Date
May 28, 2013
Volume
8581