Skip to main content

How mast cells make decisions.

Publication ,  Journal Article
Karhausen, J; Abraham, SN
Published in: The Journal of clinical investigation
October 2016

Mast cells (MCs) are present in various tissues and are responsible for initiating many of the early inflammatory responses to extrinsic challenges. Recent studies have demonstrated that MCs can tailor their responses, depending on the stimulus encountered and the tissue in which they are stimulated. In this issue of the JCI, Gaudenzio and colleagues examine the mechanistic differences between MC responses observed after engagement of Fcε receptor I and those seen after MC stimulation via the recently identified G protein-coupled receptor MRGPRX2. By showing that discrete cellular activation patterns affect the phenotype of the MC response in vivo and in vitro, the authors provide important information about how MCs differentially process various stimuli into distinct degranulation programs.

Duke Scholars

Published In

The Journal of clinical investigation

DOI

EISSN

1558-8238

ISSN

0021-9738

Publication Date

October 2016

Volume

126

Issue

10

Start / End Page

3735 / 3738

Related Subject Headings

  • Mast Cells
  • Immunology
  • Cell Degranulation
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
  • 11 Medical and Health Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Karhausen, J., & Abraham, S. N. (2016). How mast cells make decisions. The Journal of Clinical Investigation, 126(10), 3735–3738. https://doi.org/10.1172/jci90361

Published In

The Journal of clinical investigation

DOI

EISSN

1558-8238

ISSN

0021-9738

Publication Date

October 2016

Volume

126

Issue

10

Start / End Page

3735 / 3738

Related Subject Headings

  • Mast Cells
  • Immunology
  • Cell Degranulation
  • 42 Health sciences
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
  • 11 Medical and Health Sciences