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Genome-wide linkage of 77 families from the African American Hereditary Prostate Cancer study (AAHPC).

Publication ,  Journal Article
Baffoe-Bonnie, AB; Kittles, RA; Gillanders, E; Ou, L; George, A; Robbins, C; Ahaghotu, C; Bennett, J; Boykin, W; Hoke, G; Mason, T; Jones, MP ...
Published in: The Prostate
January 2007

The African American Hereditary Prostate Cancer (AAHPC) Study was designed to recruit families with early-onset disease fulfilling criteria of >or=4 affected.We present a approximately 10 cM genome-wide linkage (GWL) analysis on 77 families including 254 affected and 274 unaffected genotyped.Linkage analysis revealed three chromosomal regions with GENEHUNTER multipoint HLOD scores >or=1.3 for all 77 families at 11q22, 17p11, and Xq21. One family yielded genome-wide significant evidence of linkage (LOD = 3.5) to the 17p11 region with seven other families >or=2.3 in this region. Twenty-nine families with no-male-to-male (MM) transmission gave a peak HLOD of 1.62 (alpha = 0.33) at the Xq21 locus. Two novel peaks >or=0.91 for the 16 families with '>6 affected' occurred at 2p21 and 22q12.These chromosomal regions in the genome warrant further follow-up based on the hypothesis of multiple susceptibility genes with modest effects, or several major genes segregating in small subsets of families.

Duke Scholars

Published In

The Prostate

DOI

EISSN

1097-0045

ISSN

0270-4137

Publication Date

January 2007

Volume

67

Issue

1

Start / End Page

22 / 31

Related Subject Headings

  • United States
  • Prostatic Neoplasms
  • Pedigree
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Lod Score
  • Humans
  • Genome, Human
  • Genetic Markers
 

Citation

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MLA
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Baffoe-Bonnie, A. B., Kittles, R. A., Gillanders, E., Ou, L., George, A., Robbins, C., … Carpten, J. D. (2007). Genome-wide linkage of 77 families from the African American Hereditary Prostate Cancer study (AAHPC). The Prostate, 67(1), 22–31. https://doi.org/10.1002/pros.20456
Baffoe-Bonnie, Agnes B., Rick A. Kittles, Elizabeth Gillanders, Liang Ou, Asha George, Christiane Robbins, Chiledum Ahaghotu, et al. “Genome-wide linkage of 77 families from the African American Hereditary Prostate Cancer study (AAHPC).The Prostate 67, no. 1 (January 2007): 22–31. https://doi.org/10.1002/pros.20456.
Baffoe-Bonnie AB, Kittles RA, Gillanders E, Ou L, George A, Robbins C, et al. Genome-wide linkage of 77 families from the African American Hereditary Prostate Cancer study (AAHPC). The Prostate. 2007 Jan;67(1):22–31.
Baffoe-Bonnie, Agnes B., et al. “Genome-wide linkage of 77 families from the African American Hereditary Prostate Cancer study (AAHPC).The Prostate, vol. 67, no. 1, Jan. 2007, pp. 22–31. Epmc, doi:10.1002/pros.20456.
Baffoe-Bonnie AB, Kittles RA, Gillanders E, Ou L, George A, Robbins C, Ahaghotu C, Bennett J, Boykin W, Hoke G, Mason T, Pettaway C, Vijayakumar S, Weinrich S, Jones MP, Gildea D, Riedesel E, Albertus J, Moses T, Lockwood E, Klaric M, Faruque M, Royal C, Trent JM, Berg K, Collins FS, Furbert-Harris PM, Bailey-Wilson JE, Dunston GM, Powell I, Carpten JD. Genome-wide linkage of 77 families from the African American Hereditary Prostate Cancer study (AAHPC). The Prostate. 2007 Jan;67(1):22–31.
Journal cover image

Published In

The Prostate

DOI

EISSN

1097-0045

ISSN

0270-4137

Publication Date

January 2007

Volume

67

Issue

1

Start / End Page

22 / 31

Related Subject Headings

  • United States
  • Prostatic Neoplasms
  • Pedigree
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Lod Score
  • Humans
  • Genome, Human
  • Genetic Markers