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The Basal Forebrain and Motor Cortex Provide Convergent yet Distinct Movement-Related Inputs to the Auditory Cortex.

Publication ,  Journal Article
Nelson, A; Mooney, R
Published in: Neuron
May 4, 2016

Cholinergic inputs to the auditory cortex from the basal forebrain (BF) are important to auditory processing and plasticity, but little is known about the organization of these synapses onto different auditory cortical neuron types, how they influence auditory responsiveness, and their activity patterns during various behaviors. Using intersectional tracing, optogenetic circuit mapping, and in vivo calcium imaging, we found that cholinergic axons arising from the caudal BF target major excitatory and inhibitory auditory cortical cell types, rapidly modulate auditory cortical tuning, and display fast movement-related activity. Furthermore, the BF and the motor cortex-another source of movement-related activity-provide convergent input onto some of the same auditory cortical neurons. Cholinergic and motor cortical afferents to the auditory cortex display distinct activity patterns and presynaptic partners, indicating that the auditory cortex integrates bottom-up cholinergic signals related to ongoing movements and arousal with top-down information concerning impending movements and motor planning.

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Published In

Neuron

DOI

EISSN

1097-4199

Publication Date

May 4, 2016

Volume

90

Issue

3

Start / End Page

635 / 648

Location

United States

Related Subject Headings

  • Neurons
  • Neurology & Neurosurgery
  • Movement
  • Motor Cortex
  • Mice
  • Basal Forebrain
  • Auditory Cortex
  • Animals
  • 5202 Biological psychology
  • 3209 Neurosciences
 

Citation

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Nelson, A., & Mooney, R. (2016). The Basal Forebrain and Motor Cortex Provide Convergent yet Distinct Movement-Related Inputs to the Auditory Cortex. Neuron, 90(3), 635–648. https://doi.org/10.1016/j.neuron.2016.03.031
Nelson, Anders, and Richard Mooney. “The Basal Forebrain and Motor Cortex Provide Convergent yet Distinct Movement-Related Inputs to the Auditory Cortex.Neuron 90, no. 3 (May 4, 2016): 635–48. https://doi.org/10.1016/j.neuron.2016.03.031.
Nelson, Anders, and Richard Mooney. “The Basal Forebrain and Motor Cortex Provide Convergent yet Distinct Movement-Related Inputs to the Auditory Cortex.Neuron, vol. 90, no. 3, May 2016, pp. 635–48. Pubmed, doi:10.1016/j.neuron.2016.03.031.
Journal cover image

Published In

Neuron

DOI

EISSN

1097-4199

Publication Date

May 4, 2016

Volume

90

Issue

3

Start / End Page

635 / 648

Location

United States

Related Subject Headings

  • Neurons
  • Neurology & Neurosurgery
  • Movement
  • Motor Cortex
  • Mice
  • Basal Forebrain
  • Auditory Cortex
  • Animals
  • 5202 Biological psychology
  • 3209 Neurosciences