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Reduced effects of age on dopamine D2 receptor levels in physically active adults.

Publication ,  Journal Article
Dang, LC; Castrellon, JJ; Perkins, SF; Le, NT; Cowan, RL; Zald, DH; Samanez-Larkin, GR
Published in: NeuroImage
March 2017

Physical activity has been shown to ameliorate dopaminergic degeneration in non-human animal models. However, the effects of regular physical activity on normal age-related changes in dopamine function in humans are unknown. Here we present cross-sectional data from forty-four healthy human subjects between 23 and 80 years old, showing that typical age-related dopamine D2 receptor loss, assessed with PET [18F]fallypride, was significantly reduced in physically active adults compared to less active adults.

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Published In

NeuroImage

DOI

EISSN

1095-9572

ISSN

1053-8119

Publication Date

March 2017

Volume

148

Start / End Page

123 / 129

Related Subject Headings

  • Young Adult
  • Receptors, Dopamine D3
  • Receptors, Dopamine D2
  • Radiopharmaceuticals
  • Positron-Emission Tomography
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Humans
 

Citation

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ICMJE
MLA
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Dang, L. C., Castrellon, J. J., Perkins, S. F., Le, N. T., Cowan, R. L., Zald, D. H., & Samanez-Larkin, G. R. (2017). Reduced effects of age on dopamine D2 receptor levels in physically active adults. NeuroImage, 148, 123–129. https://doi.org/10.1016/j.neuroimage.2017.01.018
Dang, Linh C., Jaime J. Castrellon, Scott F. Perkins, Nam T. Le, Ronald L. Cowan, David H. Zald, and Gregory R. Samanez-Larkin. “Reduced effects of age on dopamine D2 receptor levels in physically active adults.NeuroImage 148 (March 2017): 123–29. https://doi.org/10.1016/j.neuroimage.2017.01.018.
Dang LC, Castrellon JJ, Perkins SF, Le NT, Cowan RL, Zald DH, et al. Reduced effects of age on dopamine D2 receptor levels in physically active adults. NeuroImage. 2017 Mar;148:123–9.
Dang, Linh C., et al. “Reduced effects of age on dopamine D2 receptor levels in physically active adults.NeuroImage, vol. 148, Mar. 2017, pp. 123–29. Epmc, doi:10.1016/j.neuroimage.2017.01.018.
Dang LC, Castrellon JJ, Perkins SF, Le NT, Cowan RL, Zald DH, Samanez-Larkin GR. Reduced effects of age on dopamine D2 receptor levels in physically active adults. NeuroImage. 2017 Mar;148:123–129.
Journal cover image

Published In

NeuroImage

DOI

EISSN

1095-9572

ISSN

1053-8119

Publication Date

March 2017

Volume

148

Start / End Page

123 / 129

Related Subject Headings

  • Young Adult
  • Receptors, Dopamine D3
  • Receptors, Dopamine D2
  • Radiopharmaceuticals
  • Positron-Emission Tomography
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Humans