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Sildenafil: Possible Prophylaxis against Swimming-induced Pulmonary Edema.

Publication ,  Journal Article
Martina, SD; Freiberger, JJ; Peacher, DF; Natoli, MJ; Schinazi, EA; Kernagis, DN; Potter, JVF; Otteni, CE; Moon, RE
Published in: Med Sci Sports Exerc
September 2017

Swimming-induced pulmonary edema (SIPE) occurs during swimming and scuba diving, usually in cold water, in susceptible healthy individuals, especially military recruits and triathletes. We have previously demonstrated that pulmonary artery (PA) pressure and PA wedge pressure are higher during immersed exercise in SIPE-susceptible individuals versus controls, confirming that SIPE is a form of hemodynamic pulmonary edema. Oral sildenafil 50 mg 1 h before immersed exercise reduced PA pressure and PA wedge pressure, suggesting that sildenafil may prevent SIPE. We present a case of a 46-yr-old female ultratriathlete with a history of at least five SIPE episodes. During a study of an exercise submerged in 20°C water, physiological parameters before and after sildenafil 50 mg orally were as follows: O2 consumption 1.75, 1.76 L·min; HR 129, 135 bpm; arterial pressure 189/88 (mean 121.5), 172/85 (mean 114.3) mm Hg; mean PA pressure 35.3, 28.8 mm Hg; and PA wedge pressure 25.3, 19.7 mm Hg. She has had no recurrences during 20 subsequent triathlons while taking 50 mg sildenafil before each swim. This case supports sildenafil as an effective prophylactic agent against SIPE during competitive surface swimming.

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Published In

Med Sci Sports Exerc

DOI

EISSN

1530-0315

Publication Date

September 2017

Volume

49

Issue

9

Start / End Page

1755 / 1757

Location

United States

Related Subject Headings

  • Vasodilator Agents
  • Swimming
  • Sport Sciences
  • Sildenafil Citrate
  • Secondary Prevention
  • Pulmonary Wedge Pressure
  • Pulmonary Edema
  • Middle Aged
  • Humans
  • Hemodynamics
 

Citation

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Martina, S. D., Freiberger, J. J., Peacher, D. F., Natoli, M. J., Schinazi, E. A., Kernagis, D. N., … Moon, R. E. (2017). Sildenafil: Possible Prophylaxis against Swimming-induced Pulmonary Edema. Med Sci Sports Exerc, 49(9), 1755–1757. https://doi.org/10.1249/MSS.0000000000001293
Martina, Stefanie D., John J. Freiberger, Dionne F. Peacher, Michael J. Natoli, Eric A. Schinazi, Dawn N. Kernagis, Jennifer V. F. Potter, Claire E. Otteni, and Richard E. Moon. “Sildenafil: Possible Prophylaxis against Swimming-induced Pulmonary Edema.Med Sci Sports Exerc 49, no. 9 (September 2017): 1755–57. https://doi.org/10.1249/MSS.0000000000001293.
Martina SD, Freiberger JJ, Peacher DF, Natoli MJ, Schinazi EA, Kernagis DN, et al. Sildenafil: Possible Prophylaxis against Swimming-induced Pulmonary Edema. Med Sci Sports Exerc. 2017 Sep;49(9):1755–7.
Martina, Stefanie D., et al. “Sildenafil: Possible Prophylaxis against Swimming-induced Pulmonary Edema.Med Sci Sports Exerc, vol. 49, no. 9, Sept. 2017, pp. 1755–57. Pubmed, doi:10.1249/MSS.0000000000001293.
Martina SD, Freiberger JJ, Peacher DF, Natoli MJ, Schinazi EA, Kernagis DN, Potter JVF, Otteni CE, Moon RE. Sildenafil: Possible Prophylaxis against Swimming-induced Pulmonary Edema. Med Sci Sports Exerc. 2017 Sep;49(9):1755–1757.

Published In

Med Sci Sports Exerc

DOI

EISSN

1530-0315

Publication Date

September 2017

Volume

49

Issue

9

Start / End Page

1755 / 1757

Location

United States

Related Subject Headings

  • Vasodilator Agents
  • Swimming
  • Sport Sciences
  • Sildenafil Citrate
  • Secondary Prevention
  • Pulmonary Wedge Pressure
  • Pulmonary Edema
  • Middle Aged
  • Humans
  • Hemodynamics