John Jacob Freiberger | Scholars@Duke

John Jacob Freiberger
Associate Professor of Anesthesiology

Dr Freiberger works on the translation of basic science research on reactive oxygen species signaling into clinical practice involving hyperbaric oxygen (HBO). He has performed animal experiments in the use of HBO for ischemic preconditioning and he is currently funded to conduct a randomized controlled trial of the use of HBO for the treatment of bisphosphonate-induced osteonecrosis of the jaw. The mechanisms of action for HBO in the treatment of: diabetic wounds, bony and soft tissue radionecrosis and decompression sickness are also areas of his inquiry. Dr Freiberger also does basic epidemiological research into accidents and injuries associated with diving, high altitude exposure and other adverse conditions associated with extreme environments. Dr. Freiberger directs the fellowship program at the Duke Center for Hyperbaric Medicine and Environmental Physiology.

Current Appointments & Affiliations

Associate Professor of Anesthesiology, Anesthesiology, Clinical Science Departments 2012

Contact Information

0570 Crii Ds, Durham, NC 27710
Box 3823 Med Ctr, Durham, NC 27710
john.freiberger@duke.edu (919) 668-0032

Background
Education, Training, & Certifications
- M.D., University of Texas at Dallas 1979
Medical Licensure
- 11990. North Carolina. 2019
Duke Appointment History
- Assistant Professor of Anesthesiology, Anesthesiology, Clinical Science Departments 2006 - 2012
- Assistant Clinical Professor of Anesthesiology, Anesthesiology, Clinical Science Departments 2001 - 2006
- Assistant Research Professor of Anesthesiology, Anesthesiology, Clinical Science Departments 2001
- Instructor, Temporary in the Department of Anesthesiology, Anesthesiology, Clinical Science Departments 2001
- Assistant Consulting Professor of Anesthesiology, Anesthesiology, Clinical Science Departments 1994 - 2000
Recognition
In the News
- SEP 24, 2018
  
  After Florence: Duke Faculty Contribution to Relief Planning
- SEP 20, 2013
  
  To the Top of Machu Picchu with ALS
Awards & Honors
- Jefferson C Davis Award. Gulf Coast Chapter of the Undersea and Hyperbaric Medical Society. August 2016
- Craig Hoffmann /Charles W. Shilling Award. Undersea and Hyperbaric Medical Society. June 2014
Research
Selected Grants
- Sildenafil for Prevention of Immersion Pulmonary Edema awarded by Naval Sea Systems Command 2019 - 2021
- Advanced Technologies for Reducing Decompression Obligation and Risk awarded by Creare, Inc. 2018 - 2020
- Does Heart Rate Variability Predict Impairment of Operational Performance in Divers? awarded by Naval Sea Systems Command 2019 - 2020
- Altitude Study awarded by Naval Sea Systems Command 2017 - 2019
- Ketogenic Diet for Reduction of CNS Oxygen Toxicity Symptoms in Working Divers - Clin 0101 awarded by Naval Sea Systems Command 2017 - 2019
- PulseOx Study awarded by Naval Sea Systems Command 2017 - 2019
- Revised Budget: Transfer of Duke Dive Trial Data-JIT for SPS 233417 awarded by Naval Sea Systems Command 2017 - 2018
- Muscoskeletal-Induced Nucleation Mechanisms in Altitute Decompression Stress awarded by National Aeronautics and Space Administration 2012 - 2017
- Effect of Riociguat on Gas Exchange, Exercise Performance, and Pulmonary Artery Pressure During Acute Altitude Exposure awarded by Wilderness Medical Society 2014 - 2015
- NASA Nucleation Study awarded by National Aeronautics and Space Administration 2006 - 2011
- Decompression to Reduce Oxygen Prebreathe Requirements for Extravehicular Activity awarded by National Aeronautics and Space Administration 2006 - 2008
- Effects of Exercise, Gas Density, and Static Lung Loads on End Tidal-Arterial PC02 Differences Breathing N2O2 Mixtures D awarded by Office of Naval Research 2003 - 2007
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Lance, RM, Natoli, MJ, Dunworth, SAS, Freiberger, JJ, and Moon, RE. "The Dewey monitor: Pulse oximetry can independently detect hypoxia in a rebreather diver." Undersea & Hyperbaric Medicine : Journal of the Undersea and Hyperbaric Medical Society, Inc 44, no. 6 (November 2017): 569-580. Open Access Copy
  - Martina, SD, Freiberger, JJ, Peacher, DF, Natoli, MJ, Schinazi, EA, Kernagis, DN, Potter, JVF, Otteni, CE, and Moon, RE. "Sildenafil: Possible Prophylaxis against Swimming-induced Pulmonary Edema." Medicine and Science in Sports and Exercise 49, no. 9 (September 2017): 1755-1757. Full Text Open Access Copy
  - Dunworth, SA, Natoli, MJ, Cooter, M, Cherry, AD, Peacher, DF, Potter, JF, Wester, TE, Freiberger, JJ, and Moon, RE. "Hypercapnia in diving: a review of CO₂ retention in submersed exercise at depth." Undersea & Hyperbaric Medicine : Journal of the Undersea and Hyperbaric Medical Society, Inc 44, no. 3 (May 2017): 191-209. Open Access Copy
  - Ceponis, P, Keilman, C, Guerry, C, and Freiberger, JJ. "Hyperbaric oxygen therapy and osteonecrosis." Oral Diseases 23, no. 2 (March 2017): 141-151. (Review) Full Text
  - Freiberger, JJ, Derrick, BJ, Natoli, MJ, Akushevich, I, Schinazi, EA, Parker, C, Stolp, BW, Bennett, PB, Vann, RD, Dunworth, SAS, and Moon, RE. "Assessment of the interaction of hyperbaric N2, CO2, and O2 on psychomotor performance in divers." Journal of Applied Physiology (Bethesda, Md. : 1985) 121, no. 4 (October 2016): 953-964. Full Text
  - Moon, RE, Martina, SD, Peacher, DF, Potter, JF, Wester, TE, Cherry, AD, Natoli, MJ, Otteni, CE, Kernagis, DN, White, WD, and Freiberger, JJ. "Swimming-Induced Pulmonary Edema: Pathophysiology and Risk Reduction With Sildenafil." Circulation 133, no. 10 (March 2016): 988-996. Full Text Open Access Copy
  - Medford, MA, Gasier, HG, Hexdall, E, Moffat, AD, Freiberger, JJ, and Moon, RE. "Research report: Charcoal type used for hookah smoking influences CO production." Undersea & Hyperbaric Medicine : Journal of the Undersea and Hyperbaric Medical Society, Inc 42, no. 4 (July 2015): 375-380. (Review)
  - Nolen, D, Cannady, SB, Wax, MK, Scharpf, J, Puscas, L, Esclamado, RM, Fritz, M, Freiberger, J, and Lee, WT. "Comparison of complications in free flap reconstruction for osteoradionecrosis in patients with or without hyperbaric oxygen therapy." Head and Neck 36, no. 12 (December 1, 2014): 1701-1704. Full Text
  - Nolen, D, Cannady, SB, Wax, MK, Scharpf, J, Puscas, L, Esclamado, RM, Fritz, M, Freiberger, J, and Lee, WT. "Comparison of complications in free flap reconstruction for osteoradionecrosis in patients with or without hyperbaric oxygen therapy." Head & Neck 36, no. 12 (December 2014): 1701-1704. Full Text
  - Torp, KD, Carraway, MS, Ott, MC, Stolp, BW, Moon, RE, Piantadosi, CA, and Freiberger, JJ. "Safe administration of hyperbaric oxygen after bleomycin: a case series of 15 patients." Undersea & Hyperbaric Medicine : Journal of the Undersea and Hyperbaric Medical Society, Inc 39, no. 5 (September 2012): 873-879.
  - Freiberger, JJ, Padilla-Burgos, R, McGraw, T, Suliman, HB, Kraft, KH, Stolp, BW, Moon, RE, and Piantadosi, CA. "What is the role of hyperbaric oxygen in the management of bisphosphonate-related osteonecrosis of the jaw: a randomized controlled trial of hyperbaric oxygen as an adjunct to surgery and antibiotics." Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons 70, no. 7 (July 2012): 1573-1583. Full Text
  - Soh, CR, Pietrobon, R, Freiberger, JJ, Chew, ST, Rajgor, D, Gandhi, M, Shah, J, and Moon, RE. "Hyperbaric oxygen therapy in necrotising soft tissue infections: a study of patients in the United States Nationwide Inpatient Sample." Intensive Care Medicine 38, no. 7 (July 2012): 1143-1151. Full Text
  - Fraser, JA, Peacher, DF, Freiberger, JJ, Natoli, MJ, Schinazi, EA, Beck, IV, Walker, JR, Doar, PO, Boso, AE, Walker, AJ, Kernagis, DN, and Moon, RE. "Erratum: Risk factors for immersion pulmonary edema: hyperoxia does not attenuate pulmonary hypertension associated with cold water-immersed prone exercise at 4.7 ATA (Journal of Applied Physiology (2011) 110 (610-618) DOI: 10.1152/japplphysiol.01088.2010)." Journal of Applied Physiology 111, no. 6 (December 1, 2011): 1888-null. Full Text
  - Fraser, JAV, Peacher, DF, Freiberger, JJ, Natoli, MJ, Schinazi, EA, Beck, IV, Walker, JR, Doar, PO, Boso, AE, Walker, AJ, Kernagis, DN, and Moon, RE. "Risk factors for immersion pulmonary edema: hyperoxia does not attenuate pulmonary hypertension associated with cold water-immersed prone exercise at 4.7 ATA." Journal of Applied Physiology (Bethesda, Md. : 1985) 110, no. 3 (March 2011): 610-618. Full Text
  - Freiberger, JJ, and Feldmeier, JJ. "Evidence supporting the use of hyperbaric oxygen in the treatment of osteoradionecrosis of the jaw." Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons 68, no. 8 (August 2010): 1903-1906. (Review) Full Text
  - Peacher, DF, Pecorella, SRH, Freiberger, JJ, Natoli, MJ, Schinazi, EA, Doar, PO, Boso, AE, Walker, AJ, Gill, M, Kernagis, D, Uguccioni, D, and Moon, RE. "Effects of hyperoxia on ventilation and pulmonary hemodynamics during immersed prone exercise at 4.7 ATA: possible implications for immersion pulmonary edema." Journal of Applied Physiology (Bethesda, Md. : 1985) 109, no. 1 (July 2010): 68-78. Full Text
  - Zeindler, PR, and Freiberger, JJ. "Triage and emergency evacuation of recreational divers: a case series analysis." Undersea & Hyperbaric Medicine : Journal of the Undersea and Hyperbaric Medical Society, Inc 37, no. 2 (March 2010): 133-139.
  - Freiberger, JJ, Yoo, DS, de Lisle Dear, G, McGraw, TA, Blakey, GH, Padilla Burgos, R, Kraft, K, Nelson, JW, Moon, RE, and Piantadosi, CA. "Multimodality surgical and hyperbaric management of mandibular osteoradionecrosis." International Journal of Radiation Oncology, Biology, Physics 75, no. 3 (November 2009): 717-724. Full Text
  - Freiberger, JJ. "Utility of hyperbaric oxygen in treatment of bisphosphonate-related osteonecrosis of the jaws." Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons 67, no. 5 Suppl (May 2009): 96-106. (Review) Full Text
  - Vann, RD, Denoble, PJ, Howle, LE, Weber, PW, Freiberger, JJ, and Pieper, CF. "Resolution and severity in decompression illness." Aviation, Space, and Environmental Medicine 80, no. 5 (May 2009): 466-471. (Review) Full Text
  - Vann, RD, Denoble, PJ, Howle, LE, Weber, PW, Freiberger, JJ, and Pieper, CF. "Resolution and severity in decompression illness." Aviation Space and Environmental Medicine 80, no. 5 PART 1 (May 1, 2009): 466-471. (Review) Full Text
  - Wester, TE, Cherry, AD, Pollock, NW, Freiberger, JJ, Natoli, MJ, Schinazi, EA, Doar, PO, Boso, AE, Alford, EL, Walker, AJ, Uguccioni, DM, Kernagis, D, and Moon, RE. "Effects of head and body cooling on hemodynamics during immersed prone exercise at 1 ATA." Journal of Applied Physiology (Bethesda, Md. : 1985) 106, no. 2 (February 2009): 691-700. Full Text
  - Cherry, AD, Forkner, IF, Frederick, HJ, Natoli, MJ, Schinazi, EA, Longphre, JP, Conard, JL, White, WD, Freiberger, JJ, Stolp, BW, Pollock, NW, Doar, PO, Boso, AE, Alford, EL, Walker, AJ, Ma, AC, Rhodes, MA, and Moon, RE. "Predictors of increased PaCO2 during immersed prone exercise at 4.7 ATA." Journal of Applied Physiology (Bethesda, Md. : 1985) 106, no. 1 (January 2009): 316-325. Full Text
  - Vann, RD, Moon, RE, Freiberger, JJ, Denoble, PJ, Dear, GL, Stolp, BW, and Massey, EW. "Decompression illness diagnosis and decompression study design." Aviation, Space, and Environmental Medicine 79, no. 8 (August 2008): 797-798. Full Text
  - Freiberger, JJ, Padilla-Burgos, R, Chhoeu, AH, Kraft, KH, Boneta, O, Moon, RE, and Piantadosi, CA. "Hyperbaric oxygen treatment and bisphosphonate-induced osteonecrosis of the jaw: a case series." Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons 65, no. 7 (July 2007): 1321-1327. Full Text
  - Vann, RD, Pollock, NW, Freiberger, JJ, Natoli, MJ, Denoble, PJ, and Pieper, CF. "Influence of bottom time on preflight surface intervals before flying after diving." Undersea & Hyperbaric Medicine : Journal of the Undersea and Hyperbaric Medical Society, Inc 34, no. 3 (May 2007): 211-220.
  - Longphre, JM, Denoble, PJ, Moon, RE, Vann, RD, and Freiberger, JJ. "First aid normobaric oxygen for the treatment of recreational diving injuries." Undersea & Hyperbaric Medicine : Journal of the Undersea and Hyperbaric Medical Society, Inc 34, no. 1 (January 2007): 43-49.
  - Freiberger, JJ, Suliman, HB, Sheng, H, McAdoo, J, Piantadosi, CA, and Warner, DS. "A comparison of hyperbaric oxygen versus hypoxic cerebral preconditioning in neonatal rats." Brain Research 1075, no. 1 (February 3, 2006): 213-222. Full Text
  - Cronje, FJ, Carraway, MS, Freiberger, JJ, Suliman, HB, and Piantadosi, CA. "Carbon monoxide actuates O(2)-limited heme degradation in the rat brain." Free Radical Biology & Medicine 37, no. 11 (December 2004): 1802-1812. Full Text
  - Freiberger, JJ, Lyman, SJ, Denoble, PJ, Pieper, CF, and Vann, RD. "Consensus factors used by experts in the diagnosis of decompression illness." Aviation, Space, and Environmental Medicine 75, no. 12 (December 2004): 1023-1028.
  - Freiberger, J, Coulombe, K, Suliman, H, Carraway, M, and Piantadosi, C. "Superoxide dismutase responds to hyperoxia in rat hippocampus." Undersea & Hyperbaric Medicine : Journal of the Undersea and Hyperbaric Medical Society, Inc 31, no. 2 (January 2004): 227-232.
  - Freiberger, JJ, Denoble, PJ, Pieper, CF, Uguccioni, DM, Pollock, NW, and Vann, RD. "The relative risk of decompression sickness during and after air travel following diving." Aviation, Space, and Environmental Medicine 73, no. 10 (October 2002): 980-984.
  - Whittington, D, Matsui-Santana, O, Freiberger, JJ, Van Houtven, G, and Pattanayak, S. "Private demand for a HIV/AIDS vaccine: evidence from Guadalajara, Mexico." Vaccine 20, no. 19-20 (June 2002): 2585-2591. Full Text
  - Freiberger, JJ, and Marsicano, TH. "Alprazolam withdrawal presenting as delirium after cardiac surgery." Journal of Cardiothoracic and Vascular Anesthesia 5, no. 2 (April 1991): 150-152. Full Text
  - GOLDBERG, JS, FREIBERGER, JJ, SLADEN, RN, and WATKINS, WD. "CLINICAL-APPLICATIONS OF PROSTAGLANDINS FOR THE ANESTHESIOLOGIST." Seminars in Anesthesia 7, no. 2 (June 1, 1988): 100-106. (Academic Article) Link to Item
  - FREIBERGER, JJ, and MARTEL, D. "THE ANALEPTIC EFFECT OF TRH ON RATS ANESTHETIZED WITH COMMONLY USED INHALATION ANESTHETICS." Anesthesiology 65, no. 3A (September 1, 1986): A105-A105. Link to Item
  - Freiberger, JJ. "An unusual presentation of an airway tear." Anesthesiology 61, no. 2 (August 1984): 204-206.
Teaching & Mentoring
Recent Courses
- ANESTH 445C: Physiology & Medicine of Extreme Environments 2019
- ME 592: Research Independent Study in Mechanical Engineering or Material Science 2018

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Education, Training, & Certifications

Medical Licensure

Duke Appointment History

In the News

Awards & Honors

Selected Grants

Selected Publications

Academic Articles

Recent Courses