John Jacob Freiberger
Adjunct Associate Professor in the Department of Anethesiology
Dr Freiberger works on the translation of basic science research on reactive oxygen species signaling into clinical practice involving hyperbaric oxygen (HBO). He has performed animal experiments in the use of HBO for ischemic preconditioning and he is currently funded to conduct a randomized controlled trial of the use of HBO for the treatment of bisphosphonate-induced osteonecrosis of the jaw. The mechanisms of action for HBO in the treatment of: diabetic wounds, bony and soft tissue radionecrosis and decompression sickness are also areas of his inquiry. Dr Freiberger also does basic epidemiological research into accidents and injuries associated with diving, high altitude exposure and other adverse conditions associated with extreme environments. Dr. Freiberger directs the fellowship program at the Duke Center for Hyperbaric Medicine and Environmental Physiology.
Current Appointments & Affiliations
- Adjunct Associate Professor in the Department of Anethesiology, Anesthesiology, Clinical Science Departments 2020
Contact Information
- 0570 Crii Ds, Durham, NC 27710
- Box 3823 Med Ctr, Durham, NC 27710
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john.freiberger@duke.edu
(919) 684-6726
- Background
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Education, Training, & Certifications
- M.D., University of Texas at Dallas 1979
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Medical Licensure
- 11990. North Carolina. 2019
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Previous Appointments & Affiliations
- Associate Professor of Anesthesiology, Anesthesiology, Clinical Science Departments 2012 - 2020
- Assistant Professor of Anesthesiology, Anesthesiology, Clinical Science Departments 2006 - 2012
- Assistant Clinical Professor of Anesthesiology, Anesthesiology, Clinical Science Departments 2001 - 2006
- Assistant Research Professor of Anesthesiology, Anesthesiology, Clinical Science Departments 2001
- Instructor, Temporary in the Department of Anesthesiology, Anesthesiology, Clinical Science Departments 2001
- Assistant Consulting Professor of Anesthesiology, Anesthesiology, Clinical Science Departments 1999 - 2000
- Assistant Consulting Professor of Anesthesiology, Anesthesiology, Clinical Science Departments 1998 - 2000
- Assistant Consulting Professor of Anesthesiology, Anesthesiology, Clinical Science Departments 1997 - 1999
- Assistant Consulting Professor of Anesthesiology, Anesthesiology, Clinical Science Departments 1996 - 1998
- Assistant Consulting Professor of Anesthesiology, Anesthesiology, Clinical Science Departments 1995 - 1997
- Assistant Consulting Professor of Anesthesiology, Anesthesiology, Clinical Science Departments 1994 - 1996
- Assistant Consulting Professor of Anesthesiology, Anesthesiology, Clinical Science Departments 1994 - 1995
- Recognition
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In the News
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SEP 4, 2019 -
SEP 24, 2018 -
SEP 20, 2013
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Awards & Honors
- Research
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Selected Grants
- Automated detection of venous gas emboli on ultrasound recordings awarded by University of North Carolina - Chapel Hill 2020 - 2023
- Altitude Study awarded by Naval Sea Systems Command 2017 - 2021
- Ketogenic Diet for Reduction of CNS Oxygen Toxicity Symptoms in Working Divers - Clin 0201 (Salary) awarded by Naval Sea Systems Command 2017 - 2021
- Advanced Technologies for Reducing Decompression Obligation and Risk awarded by Creare, Inc. 2018 - 2020
- Does Heart Rate Variability Predict Impairment of Operational Performance in Divers? awarded by Naval Sea Systems Command 2019 - 2020
- PulseOx Study awarded by Naval Sea Systems Command 2017 - 2020
- Revised Budget: Transfer of Duke Dive Trial Data-JIT for SPS 233417 awarded by Naval Sea Systems Command 2017 - 2018
- Muscoskeletal-Induced Nucleation Mechanisms in Altitute Decompression Stress awarded by National Aeronautics and Space Administration 2012 - 2017
- Effect of Riociguat on Gas Exchange, Exercise Performance, and Pulmonary Artery Pressure During Acute Altitude Exposure awarded by Wilderness Medical Society 2014 - 2015
- Mechanisms of Musculoskeletal-Induced Nucleation in Altitude Decompression Stress awarded by National Aeronautics and Space Administration 2006 - 2011
- Use of Exercise and Partial Decompression To Reduce Oxygen Prebreathe Requirements for 4.3 PSIA Extravehicular Activity awarded by National Aeronautics and Space Administration 2006 - 2008
- Effects of Exercise, Gas Density, and Static Lung Loads on End Tidal-Arterial PC02 Differences Breathing N2O2 Mixtures During Immersed Prone Exercise awarded by Office of Naval Research 2003 - 2007
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Posada-Quintero, Hugo F., Bruce J. Derrick, Christopher Winstead-Derlega, Sara I. Gonzalez, M. Claire Ellis, John J. Freiberger, and Ki H. Chon. “Time-varying Spectral Index of Electrodermal Activity to Predict Central Nervous System Oxygen Toxicity Symptoms in Divers: Preliminary results.” Annu Int Conf Ieee Eng Med Biol Soc 2021 (November 2021): 1242–45. https://doi.org/10.1109/EMBC46164.2021.9629924.Full Text Link to Item
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Lance, Rachel M., Michael J. Natoli, Sophia A. S. Dunworth, John J. Freiberger, and Richard E. Moon. “The Dewey monitor: Pulse oximetry can independently detect hypoxia in a rebreather diver.” Undersea Hyperb Med 44, no. 6 (November 2017): 569–80. https://doi.org/10.22462/11.12.2017.8.Full Text Open Access Copy Link to Item
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Martina, Stefanie D., John J. Freiberger, Dionne F. Peacher, Michael J. Natoli, Eric A. Schinazi, Dawn N. Kernagis, Jennifer V. F. Potter, Claire E. Otteni, and Richard E. Moon. “Sildenafil: Possible Prophylaxis against Swimming-induced Pulmonary Edema.” Med Sci Sports Exerc 49, no. 9 (September 2017): 1755–57. https://doi.org/10.1249/MSS.0000000000001293.Full Text Open Access Copy Link to Item
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Dunworth, Sophia A., Michael J. Natoli, Mary Cooter, Anne D. Cherry, Dionne F. Peacher, Jennifer F. Potter, Tracy E. Wester, John J. Freiberger, and Richard E. Moon. “Hypercapnia in diving: a review of CO₂ retention in submersed exercise at depth.” Undersea Hyperb Med 44, no. 3 (May 2017): 191–209. https://doi.org/10.22462/5.6.2017.1.Full Text Open Access Copy Link to Item
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Ceponis, P., C. Keilman, C. Guerry, and J. J. Freiberger. “Hyperbaric oxygen therapy and osteonecrosis.” Oral Dis 23, no. 2 (March 2017): 141–51. https://doi.org/10.1111/odi.12489.Full Text Link to Item
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Freiberger, J. J., B. J. Derrick, M. J. Natoli, I. Akushevich, E. A. Schinazi, C. Parker, B. W. Stolp, et al. “Assessment of the interaction of hyperbaric N2, CO2, and O2 on psychomotor performance in divers.” J Appl Physiol (1985) 121, no. 4 (October 1, 2016): 953–64. https://doi.org/10.1152/japplphysiol.00534.2016.Full Text Link to Item
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Moon, Richard E., Stefanie D. Martina, Dionne F. Peacher, Jennifer F. Potter, Tracy E. Wester, Anne D. Cherry, Michael J. Natoli, et al. “Swimming-Induced Pulmonary Edema: Pathophysiology and Risk Reduction With Sildenafil.” Circulation 133, no. 10 (March 8, 2016): 988–96. https://doi.org/10.1161/CIRCULATIONAHA.115.019464.Full Text Open Access Copy Link to Item
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Medford, Marlon A., Heath G. Gasier, Eric Hexdall, Andrew D. Moffat, John J. Freiberger, and Richard E. Moon. “Research report: Charcoal type used for hookah smoking influences CO production.” Undersea Hyperb Med 42, no. 4 (July 2015): 375–80.Open Access Copy Link to Item
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Nolen, David, Steven B. Cannady, Mark K. Wax, Joseph Scharpf, Liana Puscas, Ramon M. Esclamado, Michael Fritz, John Freiberger, and Walter T. Lee. “Comparison of complications in free flap reconstruction for osteoradionecrosis in patients with or without hyperbaric oxygen therapy.” Head Neck 36, no. 12 (December 2014): 1701–4. https://doi.org/10.1002/hed.23520.Full Text Link to Item
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Torp, Klaus D., Martha Sue Carraway, Michael C. Ott, Bryant W. Stolp, Richard E. Moon, Claude A. Piantadosi, and John J. Freiberger. “Safe administration of hyperbaric oxygen after bleomycin: a case series of 15 patients.” Undersea Hyperb Med 39, no. 5 (September 2012): 873–79.Link to Item
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Freiberger, John J., Rebecca Padilla-Burgos, Thomas McGraw, Hagir B. Suliman, Kevin H. Kraft, Bryant W. Stolp, Richard E. Moon, and Claude A. Piantadosi. “What is the role of hyperbaric oxygen in the management of bisphosphonate-related osteonecrosis of the jaw: a randomized controlled trial of hyperbaric oxygen as an adjunct to surgery and antibiotics.” J Oral Maxillofac Surg 70, no. 7 (July 2012): 1573–83. https://doi.org/10.1016/j.joms.2012.04.001.Full Text Link to Item
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Soh, Chai R., Ricardo Pietrobon, John J. Freiberger, Sophia T. Chew, Dimple Rajgor, Mihir Gandhi, Jatin Shah, and Richard E. Moon. “Hyperbaric oxygen therapy in necrotising soft tissue infections: a study of patients in the United States Nationwide Inpatient Sample.” Intensive Care Med 38, no. 7 (July 2012): 1143–51. https://doi.org/10.1007/s00134-012-2558-4.Full Text Link to Item
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Fraser, J. A., D. F. Peacher, J. J. Freiberger, M. J. Natoli, E. A. Schinazi, I. V. Beck, J. R. Walker, et al. “Erratum: Risk factors for immersion pulmonary edema: hyperoxia does not attenuate pulmonary hypertension associated with cold water-immersed prone exercise at 4.7 ATA (Journal of Applied Physiology (2011) 110 (610-618) DOI: 10.1152/japplphysiol.01088.2010).” Journal of Applied Physiology 111, no. 6 (December 1, 2011): 1888. https://doi.org/10.1152/japplphysiol.zdg-9898-corr.2011.Full Text
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Fraser, J. A. V., D. F. Peacher, J. J. Freiberger, M. J. Natoli, E. A. Schinazi, I. V. Beck, J. R. Walker, et al. “Risk factors for immersion pulmonary edema: hyperoxia does not attenuate pulmonary hypertension associated with cold water-immersed prone exercise at 4.7 ATA.” J Appl Physiol (1985) 110, no. 3 (March 2011): 610–18. https://doi.org/10.1152/japplphysiol.01088.2010.Full Text Link to Item
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Freiberger, John J., and John J. Feldmeier. “Evidence supporting the use of hyperbaric oxygen in the treatment of osteoradionecrosis of the jaw.” J Oral Maxillofac Surg 68, no. 8 (August 2010): 1903–6. https://doi.org/10.1016/j.joms.2010.02.001.Full Text Link to Item
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Peacher, Dionne F., Shelly R. H. Pecorella, John J. Freiberger, Michael J. Natoli, Eric A. Schinazi, P Owen Doar, Albert E. Boso, et al. “Effects of hyperoxia on ventilation and pulmonary hemodynamics during immersed prone exercise at 4.7 ATA: possible implications for immersion pulmonary edema.” J Appl Physiol (1985) 109, no. 1 (July 2010): 68–78. https://doi.org/10.1152/japplphysiol.01431.2009.Full Text Link to Item
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Zeindler, P. R., and J. J. Freiberger. “Triage and emergency evacuation of recreational divers: a case series analysis.” Undersea Hyperb Med 37, no. 2 (March 2010): 133–39.Link to Item
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Freiberger, John J., David S. Yoo, Guy de Lisle Dear, Thomas A. McGraw, George H. Blakey, Rebecca Padilla Burgos, Kevin Kraft, John W. Nelson, Richard E. Moon, and Claude A. Piantadosi. “Multimodality surgical and hyperbaric management of mandibular osteoradionecrosis.” Int J Radiat Oncol Biol Phys 75, no. 3 (November 1, 2009): 717–24. https://doi.org/10.1016/j.ijrobp.2008.11.025.Full Text Link to Item
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Freiberger, John J. “Utility of hyperbaric oxygen in treatment of bisphosphonate-related osteonecrosis of the jaws.” J Oral Maxillofac Surg 67, no. 5 Suppl (May 2009): 96–106. https://doi.org/10.1016/j.joms.2008.12.003.Full Text Link to Item
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Vann, Richard D., Petar J. Denoble, Laurens E. Howle, Paul W. Weber, John J. Freiberger, and Carl F. Pieper. “Resolution and severity in decompression illness.” Aviat Space Environ Med 80, no. 5 (May 2009): 466–71. https://doi.org/10.3357/asem.2471.2009.Full Text Link to Item
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Wester, T. E., A. D. Cherry, N. W. Pollock, J. J. Freiberger, M. J. Natoli, E. A. Schinazi, P. O. Doar, et al. “Effects of head and body cooling on hemodynamics during immersed prone exercise at 1 ATA.” J Appl Physiol (1985) 106, no. 2 (February 2009): 691–700. https://doi.org/10.1152/japplphysiol.91237.2008.Full Text Link to Item
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Cherry, A. D., I. F. Forkner, H. J. Frederick, M. J. Natoli, E. A. Schinazi, J. P. Longphre, J. L. Conard, et al. “Predictors of increased PaCO2 during immersed prone exercise at 4.7 ATA.” J Appl Physiol (1985) 106, no. 1 (January 2009): 316–25. https://doi.org/10.1152/japplphysiol.00885.2007.Full Text Link to Item
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Vann, Richard D., Richard E. Moon, John J. Freiberger, Petar J. Denoble, Guy L. Dear, Bret W. Stolp, and E Wayne Massey. “Decompression illness diagnosis and decompression study design.” Aviat Space Environ Med 79, no. 8 (August 2008): 797–98. https://doi.org/10.3357/asem.2316.2008.Full Text Link to Item
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Freiberger, John J., Rebecca Padilla-Burgos, Austin H. Chhoeu, Kevin H. Kraft, Otto Boneta, R. E. Moon, and C. A. Piantadosi. “Hyperbaric oxygen treatment and bisphosphonate-induced osteonecrosis of the jaw: a case series.” J Oral Maxillofac Surg 65, no. 7 (July 2007): 1321–27. https://doi.org/10.1016/j.joms.2007.03.019.Full Text Link to Item
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Vann, R. D., N. W. Pollock, J. J. Freiberger, M. J. Natoli, P. J. Denoble, and C. F. Pieper. “Influence of bottom time on preflight surface intervals before flying after diving.” Undersea Hyperb Med 34, no. 3 (May 2007): 211–20.Link to Item
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Longphre, J. M., P. J. Denoble, R. E. Moon, R. D. Vann, and J. J. Freiberger. “First aid normobaric oxygen for the treatment of recreational diving injuries.” Undersea Hyperb Med 34, no. 1 (January 2007): 43–49.Link to Item
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Freiberger, John J., Hagir B. Suliman, Huaxin Sheng, Jessica McAdoo, Claude A. Piantadosi, and David S. Warner. “A comparison of hyperbaric oxygen versus hypoxic cerebral preconditioning in neonatal rats.” Brain Res 1075, no. 1 (February 23, 2006): 213–22. https://doi.org/10.1016/j.brainres.2005.12.088.Full Text Link to Item
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Cronje, Frans J., Martha S. Carraway, John J. Freiberger, Hagir B. Suliman, and Claude A. Piantadosi. “Carbon monoxide actuates O(2)-limited heme degradation in the rat brain.” Free Radic Biol Med 37, no. 11 (December 1, 2004): 1802–12. https://doi.org/10.1016/j.freeradbiomed.2004.08.022.Full Text Link to Item
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Freiberger, John J., Sean J. Lyman, Petar J. Denoble, Carl F. Pieper, and Richard D. Vann. “Consensus factors used by experts in the diagnosis of decompression illness.” Aviat Space Environ Med 75, no. 12 (December 2004): 1023–28.Link to Item
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Freiberger, J., K. Coulombe, H. Suliman, M. Carraway, and C. Piantadosi. “Superoxide dismutase responds to hyperoxia in rat hippocampus.” Undersea Hyperb Med 31, no. 2 (2004): 227–32.Link to Item
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Freiberger, J. J., P. J. Denoble, C. F. Pieper, D. M. Uguccioni, N. W. Pollock, and R. D. Vann. “The relative risk of decompression sickness during and after air travel following diving.” Aviat Space Environ Med 73, no. 10 (October 2002): 980–84.Link to Item
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Whittington, Dale, Osmar Matsui-Santana, John J. Freiberger, George Van Houtven, and Subhrendu Pattanayak. “Private demand for a HIV/AIDS vaccine: evidence from Guadalajara, Mexico.” Vaccine 20, no. 19–20 (June 7, 2002): 2585–91. https://doi.org/10.1016/s0264-410x(02)00152-4.Full Text Link to Item
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Freiberger, J. J., and T. H. Marsicano. “Alprazolam withdrawal presenting as delirium after cardiac surgery.” J Cardiothorac Vasc Anesth 5, no. 2 (April 1991): 150–52. https://doi.org/10.1016/1053-0770(91)90329-r.Full Text Link to Item
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GOLDBERG, J. S., J. J. FREIBERGER, R. N. SLADEN, and W. D. WATKINS. “CLINICAL-APPLICATIONS OF PROSTAGLANDINS FOR THE ANESTHESIOLOGIST.” Seminars in Anesthesia 7, no. 2 (June 1, 1988): 100–106.Link to Item
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FREIBERGER, J. J., and D. MARTEL. “THE ANALEPTIC EFFECT OF TRH ON RATS ANESTHETIZED WITH COMMONLY USED INHALATION ANESTHETICS.” Anesthesiology 65, no. 3A (September 1, 1986): A105–A105.Link to Item
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Freiberger, J. J. “An unusual presentation of an airway tear.” Anesthesiology 61, no. 2 (August 1984): 204–6. https://doi.org/10.1097/00000542-198408000-00017.Full Text Link to Item
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Le, David Q., Paul A. Dayton, Frauke Tillmans, John J. Freiberger, Richard E. Moon, Petar Denoble, and Virginie Papadopoulou. “Ultrasound in decompression research: fundamentals, considerations, and future technologies.” Undersea Hyperb Med 48, no. 1 (n.d.): 59–72.Link to Item
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Markley, Erik, David Q. Le, Peter Germonpré, Costantino Balestra, Frauke Tillmans, Petar Denoble, John J. Freiberger, Richard E. Moon, Paul A. Dayton, and Virginie Papadopoulou. “A fully automated method for late ventricular diastole frame selection in post-dive echocardiography without ECG gating.” Undersea Hyperb Med 48, no. 1 (n.d.): 73–80.Link to Item
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