Scholars@Duke
John Jacob Freiberger

John Jacob Freiberger

Adjunct Associate Professor in the Department of Anesthesiology
Anesthesiology
john.freiberger@duke.edu
Box 3823 Med Ctr, Durham, NC
0570 CRII DS, Durham, NC 27710

Overview

Dr Freiberger works on the translation of basic science research on reactive oxygen species signaling into clinical practice involving hyperbaric oxygen (HBO). He has performed animal experiments in the use of HBO for ischemic preconditioning and he is currently funded to conduct a randomized controlled trial of the use of HBO for the treatment of bisphosphonate-induced osteonecrosis of the jaw. The mechanisms of action for HBO in the treatment of: diabetic wounds, bony and soft tissue radionecrosis and decompression sickness are also areas of his inquiry. Dr Freiberger also does basic epidemiological research into accidents and injuries associated with diving, high altitude exposure and other adverse conditions associated with extreme environments. Dr. Freiberger directs the fellowship program at the Duke Center for Hyperbaric Medicine and Environmental Physiology.

Current Appointments & Affiliations

Adjunct Associate Professor in the Department of Anesthesiology · 2020 - Present Anesthesiology, Clinical Science Departments

In the News

Published September 4, 2019
Hurricanes: How to Prepare and Why They’re Getting More Dangerous
Published September 24, 2018
After Florence: Duke Faculty Contribution to Relief Planning
Published September 20, 2013
To the Top of Machu Picchu with ALS

View All News

Recent Publications

Elevation of spectral components of electrodermal activity precedes central nervous system oxygen toxicity symptoms in divers.

Journal Article Commun Med (Lond) · December 19, 2024 BACKGROUND: Oxygen-rich breathing mixtures up to 100% are used in some underwater diving operations for several reasons. Breathing elevated oxygen partial pressures (PO2) increases the risk of developing central nervous system oxygen toxicity (CNS-OT) whic ... Full text Link to item Cite

Does Heart Rate Variability Predict Impairment of Operational Performance in Divers?

Journal Article Sensors (Basel) · December 3, 2024 We examined data from Naval Sea Systems Command grant project N0463A-12-C-001, "Hypercapnia: cognitive effects and monitoring", with the objective of validating or repudiating heart rate variability (HRV) as a warning sign of cognitive impairment from divi ... Full text Link to item Cite

Prediction of central nervous system oxygen toxicity symptoms using electrodermal activity and machine learning

Journal Article Biocybernetics and Biomedical Engineering · April 1, 2024 Objective: Breathing elevated oxygen partial pressures (PO2) prior to SCUBA diving increases the risk of developing central nervous system oxygen toxicity (CNS-OT), which could impair performance or result in seizure and subsequent drowning. We ... Full text Cite
View All Publications

Recent Grants

Automated detection of venous gas emboli on ultrasound recordings

ResearchCo Investigator · Awarded by University of North Carolina - Chapel Hill · 2020 - 2023

Altitude Study

ResearchCo Investigator · Awarded by Naval Sea Systems Command · 2017 - 2021

Ketogenic Diet for Reduction of CNS Oxygen Toxicity Symptoms in Working Divers - Clin 0201 (Salary)

ResearchCo Investigator · Awarded by Naval Sea Systems Command · 2017 - 2021

View All Grants

Education, Training & Certifications

University of Texas, Dallas · 1979 M.D.