John Jacob Freiberger | Scholars@Duke

John Jacob Freiberger
Associate Professor of Anesthesiology

Dr Freiberger works on the translation of basic science research on reactive oxygen species signaling into clinical practice involving hyperbaric oxygen (HBO). He has performed animal experiments in the use of HBO for ischemic preconditioning and he is currently funded to conduct a randomized controlled trial of the use of HBO for the treatment of bisphosphonate-induced osteonecrosis of the jaw. The mechanisms of action for HBO in the treatment of: diabetic wounds, bony and soft tissue radionecrosis and decompression sickness are also areas of his inquiry. Dr Freiberger also does basic epidemiological research into accidents and injuries associated with diving, high altitude exposure and other adverse conditions associated with extreme environments. Dr. Freiberger directs the fellowship program at the Duke Center for Hyperbaric Medicine and Environmental Physiology.

Current Appointments & Affiliations

Associate Professor of Anesthesiology, Anesthesiology, Clinical Science Departments 2012

Contact Information

0570 Crii Ds, Durham, NC 27710
Box 3823 Med Ctr, Durham, NC 27710
john.freiberger@duke.edu (919) 684-6726

Background
Education, Training, & Certifications
- M.D., University of Texas at Dallas 1979
Medical Licensure
- 11990. North Carolina. 2019
Duke Appointment History
- Assistant Professor of Anesthesiology, Anesthesiology, Clinical Science Departments 2006 - 2012
- Assistant Clinical Professor of Anesthesiology, Anesthesiology, Clinical Science Departments 2001 - 2006
- Assistant Research Professor of Anesthesiology, Anesthesiology, Clinical Science Departments 2001
- Instructor, Temporary in the Department of Anesthesiology, Anesthesiology, Clinical Science Departments 2001
- Assistant Consulting Professor of Anesthesiology, Anesthesiology, Clinical Science Departments 1994 - 2000
Recognition
In the News
- SEP 4, 2019
  
  Hurricanes: How to Prepare and Why They’re Getting More Dangerous
- SEP 24, 2018
  
  After Florence: Duke Faculty Contribution to Relief Planning
- SEP 20, 2013
  
  To the Top of Machu Picchu with ALS
Awards & Honors
- Jefferson C Davis Award. Gulf Coast Chapter of the Undersea and Hyperbaric Medical Society. August 2016
- Craig Hoffmann /Charles W. Shilling Award. Undersea and Hyperbaric Medical Society. June 2014
Research
Selected Grants
- Altitude Study 2017 - 2020
- Ketogenic Diet for Reduction of CNS Oxygen Toxicity Symptoms in Working Divers - Clin 0201 (Salary) 2017 - 2020
- Advanced Technologies for Reducing Decompression Obligation and Risk 2018 - 2020
- PulseOx Study 2017 - 2020
- Does Heart Rate Variability Predict Impairment of Operational Performance in Divers? 2019 - 2020
- Revised Budget: Transfer of Duke Dive Trial Data-JIT for SPS 233417 2017 - 2018
- Muscoskeletal-Induced Nucleation Mechanisms in Altitute Decompression Stress 2012 - 2017
- Effect of Riociguat on Gas Exchange, Exercise Performance, and Pulmonary Artery Pressure During Acute Altitude Exposure 2014 - 2015
- NASA Nucleation Study 2006 - 2011
- Decompression to Reduce Oxygen Prebreathe Requirements for Extravehicular Activity 2006 - 2008
- Effects of Exercise, Gas Density, and Static Lung Loads on End Tidal-Arterial PC02 Differences Breathing N2O2 Mixtures D awarded by Office of Naval Research 2003 - 2007
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Lance, Rachel M., Michael J. Natoli, Sophia A. S. Dunworth, John J. Freiberger, and Richard E. Moon. “The Dewey monitor: Pulse oximetry can independently detect hypoxia in a rebreather diver.” Undersea Hyperb Med 44, no. 6 (November 2017): 569–80. https://doi.org/10.22462/11.12.2017.8.
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  - Martina, Stefanie D., John J. Freiberger, Dionne F. Peacher, Michael J. Natoli, Eric A. Schinazi, Dawn N. Kernagis, Jennifer V. F. Potter, Claire E. Otteni, and Richard E. Moon. “Sildenafil: Possible Prophylaxis against Swimming-induced Pulmonary Edema.” Med Sci Sports Exerc 49, no. 9 (September 2017): 1755–57. https://doi.org/10.1249/MSS.0000000000001293.
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  - Dunworth, Sophia A., Michael J. Natoli, Mary Cooter, Anne D. Cherry, Dionne F. Peacher, Jennifer F. Potter, Tracy E. Wester, John J. Freiberger, and Richard E. Moon. “Hypercapnia in diving: a review of CO₂ retention in submersed exercise at depth.” Undersea Hyperb Med 44, no. 3 (May 2017): 191–209. https://doi.org/10.22462/5.6.2017.1.
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  - Ceponis, P., C. Keilman, C. Guerry, and J. J. Freiberger. “Hyperbaric oxygen therapy and osteonecrosis.” Oral Dis 23, no. 2 (March 2017): 141–51. https://doi.org/10.1111/odi.12489.
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  - Freiberger, J. J., B. J. Derrick, M. J. Natoli, I. Akushevich, E. A. Schinazi, C. Parker, B. W. Stolp, et al. “Assessment of the interaction of hyperbaric N2, CO2, and O2 on psychomotor performance in divers.” J Appl Physiol (1985) 121, no. 4 (October 1, 2016): 953–64. https://doi.org/10.1152/japplphysiol.00534.2016.
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  - Moon, Richard E., Stefanie D. Martina, Dionne F. Peacher, Jennifer F. Potter, Tracy E. Wester, Anne D. Cherry, Michael J. Natoli, et al. “Swimming-Induced Pulmonary Edema: Pathophysiology and Risk Reduction With Sildenafil.” Circulation 133, no. 10 (March 8, 2016): 988–96. https://doi.org/10.1161/CIRCULATIONAHA.115.019464.
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  - Medford, Marlon A., Heath G. Gasier, Eric Hexdall, Andrew D. Moffat, John J. Freiberger, and Richard E. Moon. “Research report: Charcoal type used for hookah smoking influences CO production.” Undersea Hyperb Med 42, no. 4 (July 2015): 375–80.
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  - Nolen, David, Steven B. Cannady, Mark K. Wax, Joseph Scharpf, Liana Puscas, Ramon M. Esclamado, Michael Fritz, John Freiberger, and Walter T. Lee. “Comparison of complications in free flap reconstruction for osteoradionecrosis in patients with or without hyperbaric oxygen therapy.” Head Neck 36, no. 12 (December 2014): 1701–4. https://doi.org/10.1002/hed.23520.
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  - Torp, Klaus D., Martha Sue Carraway, Michael C. Ott, Bryant W. Stolp, Richard E. Moon, Claude A. Piantadosi, and John J. Freiberger. “Safe administration of hyperbaric oxygen after bleomycin: a case series of 15 patients.” Undersea Hyperb Med 39, no. 5 (September 2012): 873–79.
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  - Freiberger, John J., Rebecca Padilla-Burgos, Thomas McGraw, Hagir B. Suliman, Kevin H. Kraft, Bryant W. Stolp, Richard E. Moon, and Claude A. Piantadosi. “What is the role of hyperbaric oxygen in the management of bisphosphonate-related osteonecrosis of the jaw: a randomized controlled trial of hyperbaric oxygen as an adjunct to surgery and antibiotics.” J Oral Maxillofac Surg 70, no. 7 (July 2012): 1573–83. https://doi.org/10.1016/j.joms.2012.04.001.
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  - Soh, Chai R., Ricardo Pietrobon, John J. Freiberger, Sophia T. Chew, Dimple Rajgor, Mihir Gandhi, Jatin Shah, and Richard E. Moon. “Hyperbaric oxygen therapy in necrotising soft tissue infections: a study of patients in the United States Nationwide Inpatient Sample.” Intensive Care Med 38, no. 7 (July 2012): 1143–51. https://doi.org/10.1007/s00134-012-2558-4.
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  - Fraser, J. A., D. F. Peacher, J. J. Freiberger, M. J. Natoli, E. A. Schinazi, I. V. Beck, J. R. Walker, et al. “Erratum: Risk factors for immersion pulmonary edema: hyperoxia does not attenuate pulmonary hypertension associated with cold water-immersed prone exercise at 4.7 ATA (Journal of Applied Physiology (2011) 110 (610-618) DOI: 10.1152/japplphysiol.01088.2010).” Journal of Applied Physiology 111, no. 6 (December 1, 2011): 1888. https://doi.org/10.1152/japplphysiol.zdg-9898-corr.2011.
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  - Fraser, J. A. V., D. F. Peacher, J. J. Freiberger, M. J. Natoli, E. A. Schinazi, I. V. Beck, J. R. Walker, et al. “Risk factors for immersion pulmonary edema: hyperoxia does not attenuate pulmonary hypertension associated with cold water-immersed prone exercise at 4.7 ATA.” J Appl Physiol (1985) 110, no. 3 (March 2011): 610–18. https://doi.org/10.1152/japplphysiol.01088.2010.
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  - Freiberger, John J., and John J. Feldmeier. “Evidence supporting the use of hyperbaric oxygen in the treatment of osteoradionecrosis of the jaw.” J Oral Maxillofac Surg 68, no. 8 (August 2010): 1903–6. https://doi.org/10.1016/j.joms.2010.02.001.
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  - Peacher, Dionne F., Shelly R. H. Pecorella, John J. Freiberger, Michael J. Natoli, Eric A. Schinazi, P Owen Doar, Albert E. Boso, et al. “Effects of hyperoxia on ventilation and pulmonary hemodynamics during immersed prone exercise at 4.7 ATA: possible implications for immersion pulmonary edema.” J Appl Physiol (1985) 109, no. 1 (July 2010): 68–78. https://doi.org/10.1152/japplphysiol.01431.2009.
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  - Zeindler, P. R., and J. J. Freiberger. “Triage and emergency evacuation of recreational divers: a case series analysis.” Undersea Hyperb Med 37, no. 2 (March 2010): 133–39.
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  - Freiberger, John J., David S. Yoo, Guy de Lisle Dear, Thomas A. McGraw, George H. Blakey, Rebecca Padilla Burgos, Kevin Kraft, John W. Nelson, Richard E. Moon, and Claude A. Piantadosi. “Multimodality surgical and hyperbaric management of mandibular osteoradionecrosis.” Int J Radiat Oncol Biol Phys 75, no. 3 (November 1, 2009): 717–24. https://doi.org/10.1016/j.ijrobp.2008.11.025.
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  - Freiberger, John J. “Utility of hyperbaric oxygen in treatment of bisphosphonate-related osteonecrosis of the jaws.” J Oral Maxillofac Surg 67, no. 5 Suppl (May 2009): 96–106. https://doi.org/10.1016/j.joms.2008.12.003.
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  - Vann, Richard D., Petar J. Denoble, Laurens E. Howle, Paul W. Weber, John J. Freiberger, and Carl F. Pieper. “Resolution and severity in decompression illness.” Aviat Space Environ Med 80, no. 5 (May 2009): 466–71. https://doi.org/10.3357/asem.2471.2009.
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  - Wester, T. E., A. D. Cherry, N. W. Pollock, J. J. Freiberger, M. J. Natoli, E. A. Schinazi, P. O. Doar, et al. “Effects of head and body cooling on hemodynamics during immersed prone exercise at 1 ATA.” J Appl Physiol (1985) 106, no. 2 (February 2009): 691–700. https://doi.org/10.1152/japplphysiol.91237.2008.
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  - Cherry, A. D., I. F. Forkner, H. J. Frederick, M. J. Natoli, E. A. Schinazi, J. P. Longphre, J. L. Conard, et al. “Predictors of increased PaCO2 during immersed prone exercise at 4.7 ATA.” J Appl Physiol (1985) 106, no. 1 (January 2009): 316–25. https://doi.org/10.1152/japplphysiol.00885.2007.
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  - Vann, Richard D., Richard E. Moon, John J. Freiberger, Petar J. Denoble, Guy L. Dear, Bret W. Stolp, and E Wayne Massey. “Decompression illness diagnosis and decompression study design.” Aviat Space Environ Med 79, no. 8 (August 2008): 797–98. https://doi.org/10.3357/asem.2316.2008.
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  - Freiberger, John J., Rebecca Padilla-Burgos, Austin H. Chhoeu, Kevin H. Kraft, Otto Boneta, R. E. Moon, and C. A. Piantadosi. “Hyperbaric oxygen treatment and bisphosphonate-induced osteonecrosis of the jaw: a case series.” J Oral Maxillofac Surg 65, no. 7 (July 2007): 1321–27. https://doi.org/10.1016/j.joms.2007.03.019.
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  - Vann, R. D., N. W. Pollock, J. J. Freiberger, M. J. Natoli, P. J. Denoble, and C. F. Pieper. “Influence of bottom time on preflight surface intervals before flying after diving.” Undersea Hyperb Med 34, no. 3 (May 2007): 211–20.
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  - Longphre, J. M., P. J. Denoble, R. E. Moon, R. D. Vann, and J. J. Freiberger. “First aid normobaric oxygen for the treatment of recreational diving injuries.” Undersea Hyperb Med 34, no. 1 (January 2007): 43–49.
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  - Freiberger, John J., Hagir B. Suliman, Huaxin Sheng, Jessica McAdoo, Claude A. Piantadosi, and David S. Warner. “A comparison of hyperbaric oxygen versus hypoxic cerebral preconditioning in neonatal rats.” Brain Res 1075, no. 1 (February 23, 2006): 213–22. https://doi.org/10.1016/j.brainres.2005.12.088.
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  - Cronje, Frans J., Martha S. Carraway, John J. Freiberger, Hagir B. Suliman, and Claude A. Piantadosi. “Carbon monoxide actuates O(2)-limited heme degradation in the rat brain.” Free Radic Biol Med 37, no. 11 (December 1, 2004): 1802–12. https://doi.org/10.1016/j.freeradbiomed.2004.08.022.
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  - Freiberger, John J., Sean J. Lyman, Petar J. Denoble, Carl F. Pieper, and Richard D. Vann. “Consensus factors used by experts in the diagnosis of decompression illness.” Aviat Space Environ Med 75, no. 12 (December 2004): 1023–28.
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  - Freiberger, J., K. Coulombe, H. Suliman, M. Carraway, and C. Piantadosi. “Superoxide dismutase responds to hyperoxia in rat hippocampus.” Undersea Hyperb Med 31, no. 2 (2004): 227–32.
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  - Freiberger, J. J., P. J. Denoble, C. F. Pieper, D. M. Uguccioni, N. W. Pollock, and R. D. Vann. “The relative risk of decompression sickness during and after air travel following diving.” Aviat Space Environ Med 73, no. 10 (October 2002): 980–84.
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  - Whittington, Dale, Osmar Matsui-Santana, John J. Freiberger, George Van Houtven, and Subhrendu Pattanayak. “Private demand for a HIV/AIDS vaccine: evidence from Guadalajara, Mexico.” Vaccine 20, no. 19–20 (June 2002): 2585–91. https://doi.org/10.1016/s0264-410x(02)00152-4.
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  - Freiberger, J. J., and T. H. Marsicano. “Alprazolam withdrawal presenting as delirium after cardiac surgery.” J Cardiothorac Vasc Anesth 5, no. 2 (April 1991): 150–52. https://doi.org/10.1016/1053-0770(91)90329-r.
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  - GOLDBERG, J. S., J. J. FREIBERGER, R. N. SLADEN, and W. D. WATKINS. “CLINICAL-APPLICATIONS OF PROSTAGLANDINS FOR THE ANESTHESIOLOGIST.” Seminars in Anesthesia 7, no. 2 (June 1, 1988): 100–106.
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  - FREIBERGER, J. J., and D. MARTEL. “THE ANALEPTIC EFFECT OF TRH ON RATS ANESTHETIZED WITH COMMONLY USED INHALATION ANESTHETICS.” Anesthesiology 65, no. 3A (September 1, 1986): A105–A105.
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  - Freiberger, J. J. “An unusual presentation of an airway tear.” Anesthesiology 61, no. 2 (August 1984): 204–6. https://doi.org/10.1097/00000542-198408000-00017.
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Teaching & Mentoring
Recent Courses
- ANESTH 445C: Physiology & Medicine of Extreme Environments 2019
- ME 592: Research Independent Study in Mechanical Engineering or Material Science 2018

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Education, Training, & Certifications

Medical Licensure

Duke Appointment History

In the News

Awards & Honors

Selected Grants

Selected Publications

Academic Articles

Recent Courses