Skip to main content
Journal cover image

From Composition to Cure: A Systems Engineering Approach to Anticancer Drug Carriers.

Publication ,  Journal Article
MacEwan, SR; Chilkoti, A
Published in: Angewandte Chemie (International ed. in English)
June 2017

The molecular complexity and heterogeneity of cancer has led to a persistent, and as yet unsolved, challenge to develop cures for this disease. The pharmaceutical industry focuses the bulk of its efforts on the development of new drugs, but an alternative approach is to improve the delivery of existing drugs with drug carriers that can manipulate when, where, and how a drug exerts its therapeutic effect. For the treatment of solid tumors, systemically delivered drug carriers face significant challenges that are imposed by the pathophysiological barriers that lie between their site of administration and their site of therapeutic action in the tumor. Furthermore, drug carriers face additional challenges in their translation from preclinical validation to clinical approval and adoption. Addressing this diverse network of challenges requires a systems engineering approach for the rational design of optimized carriers that have a realistic prospect for translation from the laboratory to the patient.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Angewandte Chemie (International ed. in English)

DOI

EISSN

1521-3773

ISSN

1433-7851

Publication Date

June 2017

Volume

56

Issue

24

Start / End Page

6712 / 6733

Related Subject Headings

  • Subcellular Fractions
  • Organic Chemistry
  • Neoplasms
  • Humans
  • Drug Discovery
  • Drug Delivery Systems
  • Drug Carriers
  • Antineoplastic Agents
  • 34 Chemical sciences
  • 03 Chemical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
MacEwan, S. R., & Chilkoti, A. (2017). From Composition to Cure: A Systems Engineering Approach to Anticancer Drug Carriers. Angewandte Chemie (International Ed. in English), 56(24), 6712–6733. https://doi.org/10.1002/anie.201610819
MacEwan, Sarah R., and Ashutosh Chilkoti. “From Composition to Cure: A Systems Engineering Approach to Anticancer Drug Carriers.Angewandte Chemie (International Ed. in English) 56, no. 24 (June 2017): 6712–33. https://doi.org/10.1002/anie.201610819.
MacEwan SR, Chilkoti A. From Composition to Cure: A Systems Engineering Approach to Anticancer Drug Carriers. Angewandte Chemie (International ed in English). 2017 Jun;56(24):6712–33.
MacEwan, Sarah R., and Ashutosh Chilkoti. “From Composition to Cure: A Systems Engineering Approach to Anticancer Drug Carriers.Angewandte Chemie (International Ed. in English), vol. 56, no. 24, June 2017, pp. 6712–33. Epmc, doi:10.1002/anie.201610819.
MacEwan SR, Chilkoti A. From Composition to Cure: A Systems Engineering Approach to Anticancer Drug Carriers. Angewandte Chemie (International ed in English). 2017 Jun;56(24):6712–6733.
Journal cover image

Published In

Angewandte Chemie (International ed. in English)

DOI

EISSN

1521-3773

ISSN

1433-7851

Publication Date

June 2017

Volume

56

Issue

24

Start / End Page

6712 / 6733

Related Subject Headings

  • Subcellular Fractions
  • Organic Chemistry
  • Neoplasms
  • Humans
  • Drug Discovery
  • Drug Delivery Systems
  • Drug Carriers
  • Antineoplastic Agents
  • 34 Chemical sciences
  • 03 Chemical Sciences