Toward Hyperpolarized 19 F Molecular Imaging via Reversible Exchange with Parahydrogen.
Fluorine-19 has high NMR detection sensitivity-similar to that of protons-owing to its large gyromagnetic ratio and high natural abundance (100 %). Unlike protons, however, fluorine-19 (19 F) has a negligible occurrence in biological objects, as well as a more sensitive chemical shift. As a result, in vivo 19 F NMR spectroscopy and MR imaging offer advantages of negligible background signal and sensitive reporting of the local molecular environment. Here we report on NMR hyperpolarization of 19 F nuclei using reversible exchange reactions with parahydrogen gas as the source of nuclear spin order. NMR signals of 3-fluoropyridine were enhanced by ≈100 fold, corresponding to 0.3 % 19 F nuclear spin polarization (at 9.4 T), using about 50 % parahydrogen. While future optimization efforts will likely significantly increase the hyperpolarization levels, we already demonstrate the utility of 19 F hyperpolarization for high-resolution hyperpolarized 19 F imaging and hyperpolarized 19 F pH sensing.
Duke Scholars
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Related Subject Headings
- Molecular Imaging
- Magnetic Resonance Spectroscopy
- Hydrogen-Ion Concentration
- Hydrogen
- Fluorine
- Chemical Physics
- 3406 Physical chemistry
- 3403 Macromolecular and materials chemistry
- 0307 Theoretical and Computational Chemistry
- 0306 Physical Chemistry (incl. Structural)
Citation
Published In
DOI
EISSN
ISSN
Publication Date
Volume
Issue
Start / End Page
Related Subject Headings
- Molecular Imaging
- Magnetic Resonance Spectroscopy
- Hydrogen-Ion Concentration
- Hydrogen
- Fluorine
- Chemical Physics
- 3406 Physical chemistry
- 3403 Macromolecular and materials chemistry
- 0307 Theoretical and Computational Chemistry
- 0306 Physical Chemistry (incl. Structural)