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Toward Hyperpolarized 19 F Molecular Imaging via Reversible Exchange with Parahydrogen.

Publication ,  Journal Article
Shchepin, RV; Goodson, BM; Theis, T; Warren, WS; Chekmenev, EY
Published in: Chemphyschem : a European journal of chemical physics and physical chemistry
August 2017

Fluorine-19 has high NMR detection sensitivity-similar to that of protons-owing to its large gyromagnetic ratio and high natural abundance (100 %). Unlike protons, however, fluorine-19 (19 F) has a negligible occurrence in biological objects, as well as a more sensitive chemical shift. As a result, in vivo 19 F NMR spectroscopy and MR imaging offer advantages of negligible background signal and sensitive reporting of the local molecular environment. Here we report on NMR hyperpolarization of 19 F nuclei using reversible exchange reactions with parahydrogen gas as the source of nuclear spin order. NMR signals of 3-fluoropyridine were enhanced by ≈100 fold, corresponding to 0.3 % 19 F nuclear spin polarization (at 9.4 T), using about 50 % parahydrogen. While future optimization efforts will likely significantly increase the hyperpolarization levels, we already demonstrate the utility of 19 F hyperpolarization for high-resolution hyperpolarized 19 F imaging and hyperpolarized 19 F pH sensing.

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Published In

Chemphyschem : a European journal of chemical physics and physical chemistry

DOI

EISSN

1439-7641

ISSN

1439-4235

Publication Date

August 2017

Volume

18

Issue

15

Start / End Page

1961 / 1965

Related Subject Headings

  • Molecular Imaging
  • Magnetic Resonance Spectroscopy
  • Hydrogen-Ion Concentration
  • Hydrogen
  • Fluorine
  • Chemical Physics
  • 3406 Physical chemistry
  • 3403 Macromolecular and materials chemistry
  • 0307 Theoretical and Computational Chemistry
  • 0306 Physical Chemistry (incl. Structural)
 

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Shchepin, R. V., Goodson, B. M., Theis, T., Warren, W. S., & Chekmenev, E. Y. (2017). Toward Hyperpolarized 19 F Molecular Imaging via Reversible Exchange with Parahydrogen. Chemphyschem : A European Journal of Chemical Physics and Physical Chemistry, 18(15), 1961–1965. https://doi.org/10.1002/cphc.201700594
Shchepin, Roman V., Boyd M. Goodson, Thomas Theis, Warren S. Warren, and Eduard Y. Chekmenev. “Toward Hyperpolarized 19 F Molecular Imaging via Reversible Exchange with Parahydrogen.Chemphyschem : A European Journal of Chemical Physics and Physical Chemistry 18, no. 15 (August 2017): 1961–65. https://doi.org/10.1002/cphc.201700594.
Shchepin RV, Goodson BM, Theis T, Warren WS, Chekmenev EY. Toward Hyperpolarized 19 F Molecular Imaging via Reversible Exchange with Parahydrogen. Chemphyschem : a European journal of chemical physics and physical chemistry. 2017 Aug;18(15):1961–5.
Shchepin, Roman V., et al. “Toward Hyperpolarized 19 F Molecular Imaging via Reversible Exchange with Parahydrogen.Chemphyschem : A European Journal of Chemical Physics and Physical Chemistry, vol. 18, no. 15, Aug. 2017, pp. 1961–65. Epmc, doi:10.1002/cphc.201700594.
Shchepin RV, Goodson BM, Theis T, Warren WS, Chekmenev EY. Toward Hyperpolarized 19 F Molecular Imaging via Reversible Exchange with Parahydrogen. Chemphyschem : a European journal of chemical physics and physical chemistry. 2017 Aug;18(15):1961–1965.
Journal cover image

Published In

Chemphyschem : a European journal of chemical physics and physical chemistry

DOI

EISSN

1439-7641

ISSN

1439-4235

Publication Date

August 2017

Volume

18

Issue

15

Start / End Page

1961 / 1965

Related Subject Headings

  • Molecular Imaging
  • Magnetic Resonance Spectroscopy
  • Hydrogen-Ion Concentration
  • Hydrogen
  • Fluorine
  • Chemical Physics
  • 3406 Physical chemistry
  • 3403 Macromolecular and materials chemistry
  • 0307 Theoretical and Computational Chemistry
  • 0306 Physical Chemistry (incl. Structural)