The Top1 paradox: Friend and foe of the eukaryotic genome.
Publication
, Journal Article
Kim, N; Jinks-Robertson, S
Published in: DNA Repair (Amst)
August 2017
Topoisomerases manage the torsional stress associated with the separation of DNA strands during transcription and DNA replication. Eukaryotic Topoisomerase I (Top1) is a Type IB enzyme that nicks and rejoins only one strand of duplex DNA, and it is especially important during transcription. By resolving transcription-associated torsional stress, Top1 reduces the accumulation of genome-destabilizing R-loops and non-B DNA structures. The DNA nicking activity of Top1, however, can also initiate genome instability in the form of illegitimate recombination, homologous recombination and mutagenesis. In this review, we focus on the diverse, and often opposing, roles of Top1 in regulating eukaryotic genome stability.
Duke Scholars
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Published In
DNA Repair (Amst)
DOI
EISSN
1568-7856
Publication Date
August 2017
Volume
56
Start / End Page
33 / 41
Location
Netherlands
Related Subject Headings
- Humans
- Genomic Instability
- Eukaryota
- Developmental Biology
- DNA Topoisomerases, Type I
- DNA
- Animals
- 3101 Biochemistry and cell biology
- 0601 Biochemistry and Cell Biology
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MLA
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Kim, N., & Jinks-Robertson, S. (2017). The Top1 paradox: Friend and foe of the eukaryotic genome. DNA Repair (Amst), 56, 33–41. https://doi.org/10.1016/j.dnarep.2017.06.005
Kim, Nayun, and Sue Jinks-Robertson. “The Top1 paradox: Friend and foe of the eukaryotic genome.” DNA Repair (Amst) 56 (August 2017): 33–41. https://doi.org/10.1016/j.dnarep.2017.06.005.
Kim N, Jinks-Robertson S. The Top1 paradox: Friend and foe of the eukaryotic genome. DNA Repair (Amst). 2017 Aug;56:33–41.
Kim, Nayun, and Sue Jinks-Robertson. “The Top1 paradox: Friend and foe of the eukaryotic genome.” DNA Repair (Amst), vol. 56, Aug. 2017, pp. 33–41. Pubmed, doi:10.1016/j.dnarep.2017.06.005.
Kim N, Jinks-Robertson S. The Top1 paradox: Friend and foe of the eukaryotic genome. DNA Repair (Amst). 2017 Aug;56:33–41.
Published In
DNA Repair (Amst)
DOI
EISSN
1568-7856
Publication Date
August 2017
Volume
56
Start / End Page
33 / 41
Location
Netherlands
Related Subject Headings
- Humans
- Genomic Instability
- Eukaryota
- Developmental Biology
- DNA Topoisomerases, Type I
- DNA
- Animals
- 3101 Biochemistry and cell biology
- 0601 Biochemistry and Cell Biology