Skip to main content
Journal cover image

Diazirines as Potential Molecular Imaging Tags: Probing the Requirements for Efficient and Long‐Lived SABRE‐Induced Hyperpolarization

Publication ,  Journal Article
Shen, K; Logan, AWJ; Colell, JFP; Bae, J; Ortiz, GX; Theis, T; Warren, WS; Malcolmson, SJ; Wang, Q
Published in: Angewandte Chemie
September 25, 2017

Diazirines are an attractive class of potential molecular tags for magnetic resonance imaging owing to their biocompatibility and ease of incorporation into a large variety of molecules. As recently reported, N‐diazirine can be hyperpolarized by the SABRE‐SHEATH method, sustaining both singlet and magnetization states, thus offering a path to long‐lived polarization storage. Herein, we show the generality of this approach by illustrating that the diazirine tag alone is sufficient for achieving excellent signal enhancements with long‐lasting polarization. Our investigations reveal the critical role of Lewis basic additives, including water, on achieving SABRE‐promoted hyperpolarization. The application of this strategy to a N‐diazirine‐containing choline derivative demonstrates the potential of N‐diazirines as molecular imaging tags for biomedical applications.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Angewandte Chemie

DOI

EISSN

1521-3757

ISSN

0044-8249

Publication Date

September 25, 2017

Volume

129

Issue

40

Start / End Page

12280 / 12284

Publisher

Wiley

Related Subject Headings

  • Organic Chemistry
  • 03 Chemical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Shen, K., Logan, A. W. J., Colell, J. F. P., Bae, J., Ortiz, G. X., Theis, T., … Wang, Q. (2017). Diazirines as Potential Molecular Imaging Tags: Probing the Requirements for Efficient and Long‐Lived SABRE‐Induced Hyperpolarization. Angewandte Chemie, 129(40), 12280–12284. https://doi.org/10.1002/ange.201704970
Shen, Kun, Angus W. J. Logan, Johannes F. P. Colell, Junu Bae, Gerardo X. Ortiz, Thomas Theis, Warren S. Warren, Steven J. Malcolmson, and Qiu Wang. “Diazirines as Potential Molecular Imaging Tags: Probing the Requirements for Efficient and Long‐Lived SABRE‐Induced Hyperpolarization.” Angewandte Chemie 129, no. 40 (September 25, 2017): 12280–84. https://doi.org/10.1002/ange.201704970.
Shen K, Logan AWJ, Colell JFP, Bae J, Ortiz GX, Theis T, et al. Diazirines as Potential Molecular Imaging Tags: Probing the Requirements for Efficient and Long‐Lived SABRE‐Induced Hyperpolarization. Angewandte Chemie. 2017 Sep 25;129(40):12280–4.
Shen, Kun, et al. “Diazirines as Potential Molecular Imaging Tags: Probing the Requirements for Efficient and Long‐Lived SABRE‐Induced Hyperpolarization.” Angewandte Chemie, vol. 129, no. 40, Wiley, Sept. 2017, pp. 12280–84. Crossref, doi:10.1002/ange.201704970.
Shen K, Logan AWJ, Colell JFP, Bae J, Ortiz GX, Theis T, Warren WS, Malcolmson SJ, Wang Q. Diazirines as Potential Molecular Imaging Tags: Probing the Requirements for Efficient and Long‐Lived SABRE‐Induced Hyperpolarization. Angewandte Chemie. Wiley; 2017 Sep 25;129(40):12280–12284.
Journal cover image

Published In

Angewandte Chemie

DOI

EISSN

1521-3757

ISSN

0044-8249

Publication Date

September 25, 2017

Volume

129

Issue

40

Start / End Page

12280 / 12284

Publisher

Wiley

Related Subject Headings

  • Organic Chemistry
  • 03 Chemical Sciences