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Lung transplantation delays gastric motility in patients without prior gastrointestinal surgery-A single-center experience of 412 consecutive patients.

Publication ,  Journal Article
Hirji, SA; Gulack, BC; Englum, BR; Speicher, PJ; Ganapathi, AM; Osho, AA; Shimpi, RA; Perez, A; Hartwig, MG
Published in: Clin Transplant
October 2017

PURPOSE: To examine the impact of lung transplantation on gastric motility. METHODS: Adult recipients at a large, single center, who were retrospectively evaluated with solid gastric emptying (SGE) study post-lung transplantation, but had no history of gastrointestinal intervention (ie, pyloroplasty or fundoplication), were selected between June 2005 and August 2013. Multivariable logistic regression was performed to determine risk factors associated with delayed gastric emptying (DGE) after transplantation. RESULTS: Delayed gastric emptying (DGE) was noted in 236 patients (57%) after transplantation. On multivariable logistic regression, an underlining diagnosis of cystic fibrosis (CF)/bronchiectasis (adjusted odds ratio [AOR] 3.26, P < .01) was a significant risk factor in predicting DGE after lung transplantation. There was no survival difference between patients with postoperative DGE vs those without (log-rank test P = .53). CONCLUSIONS: Delayed gastric emptying is very common following lung transplantation, occurring in over half of all lung transplant recipients with increased prevalence in patients with CF. The association with cystic fibrosis could be secondary to extra-pulmonary manifestations of the underlying disease or indicative of increased intraoperative vagal nerve injury. We speculate that DGE may play a substantial role in the increased reflux-induced allograft injury seen after lung transplantation. Further prospective studies are needed to validate this hypothesis.

Duke Scholars

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Published In

Clin Transplant

DOI

EISSN

1399-0012

Publication Date

October 2017

Volume

31

Issue

10

Location

Denmark

Related Subject Headings

  • Transplantation, Homologous
  • Surgery
  • Risk Factors
  • Retrospective Studies
  • Prognosis
  • Postoperative Complications
  • Middle Aged
  • Male
  • Lung Transplantation
  • Humans
 

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Hirji, S. A., Gulack, B. C., Englum, B. R., Speicher, P. J., Ganapathi, A. M., Osho, A. A., … Hartwig, M. G. (2017). Lung transplantation delays gastric motility in patients without prior gastrointestinal surgery-A single-center experience of 412 consecutive patients. Clin Transplant, 31(10). https://doi.org/10.1111/ctr.13065
Hirji, Sameer A., Brian C. Gulack, Brian R. Englum, Paul J. Speicher, Asvin M. Ganapathi, Asishana A. Osho, Rahul A. Shimpi, Alexander Perez, and Matthew G. Hartwig. “Lung transplantation delays gastric motility in patients without prior gastrointestinal surgery-A single-center experience of 412 consecutive patients.Clin Transplant 31, no. 10 (October 2017). https://doi.org/10.1111/ctr.13065.
Hirji SA, Gulack BC, Englum BR, Speicher PJ, Ganapathi AM, Osho AA, et al. Lung transplantation delays gastric motility in patients without prior gastrointestinal surgery-A single-center experience of 412 consecutive patients. Clin Transplant. 2017 Oct;31(10).
Hirji, Sameer A., et al. “Lung transplantation delays gastric motility in patients without prior gastrointestinal surgery-A single-center experience of 412 consecutive patients.Clin Transplant, vol. 31, no. 10, Oct. 2017. Pubmed, doi:10.1111/ctr.13065.
Hirji SA, Gulack BC, Englum BR, Speicher PJ, Ganapathi AM, Osho AA, Shimpi RA, Perez A, Hartwig MG. Lung transplantation delays gastric motility in patients without prior gastrointestinal surgery-A single-center experience of 412 consecutive patients. Clin Transplant. 2017 Oct;31(10).
Journal cover image

Published In

Clin Transplant

DOI

EISSN

1399-0012

Publication Date

October 2017

Volume

31

Issue

10

Location

Denmark

Related Subject Headings

  • Transplantation, Homologous
  • Surgery
  • Risk Factors
  • Retrospective Studies
  • Prognosis
  • Postoperative Complications
  • Middle Aged
  • Male
  • Lung Transplantation
  • Humans