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Biomaterials for pluripotent stem cell engineering: From fate determination to vascularization

Publication ,  Journal Article
Seale, NM; Varghese, S
Published in: Journal of Materials Chemistry B
January 1, 2016

Recent advancements in materials science and engineering may hold the key to overcoming reproducibility and scalability limitations currently hindering the clinical translation of stem cell therapies. Biomaterial assisted differentiation commitment of stem cells and modulation of their in vivo function could have a significant impact on stem cell-centred regenerative medicine approaches and next generation technological platforms. Synthetic biomaterials are of particular interest as they provide a consistent, chemically defined, and tunable way of mimicking the physical and chemical properties of the natural tissue or cell environment. Combining the emerging biomaterial and biofabrication advancements may finally give researchers the tools to modulate spatiotemporal complexity and engineer more hierarchically complex, physiologically relevant tissue mimics. In this review we highlight recent research advancements in biomaterial assisted pluripotent stem cell (PSC) expansion and three dimensional (3D) tissue formation strategies. Furthermore, since vascularization is a major challenge affecting the in vivo function of engineered tissues, we discuss recent developments in vascularization strategies and assess their ability to produce perfusable and functional vasculature that can be integrated with the host tissue.

Duke Scholars

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Published In

Journal of Materials Chemistry B

DOI

EISSN

2050-750X

ISSN

2050-7518

Publication Date

January 1, 2016

Volume

4

Issue

20

Start / End Page

3454 / 3463

Related Subject Headings

  • 4004 Chemical engineering
  • 4003 Biomedical engineering
  • 3403 Macromolecular and materials chemistry
  • 0903 Biomedical Engineering
  • 0303 Macromolecular and Materials Chemistry
 

Citation

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Seale, N. M., & Varghese, S. (2016). Biomaterials for pluripotent stem cell engineering: From fate determination to vascularization. Journal of Materials Chemistry B, 4(20), 3454–3463. https://doi.org/10.1039/c5tb02658j
Seale, N. M., and S. Varghese. “Biomaterials for pluripotent stem cell engineering: From fate determination to vascularization.” Journal of Materials Chemistry B 4, no. 20 (January 1, 2016): 3454–63. https://doi.org/10.1039/c5tb02658j.
Seale NM, Varghese S. Biomaterials for pluripotent stem cell engineering: From fate determination to vascularization. Journal of Materials Chemistry B. 2016 Jan 1;4(20):3454–63.
Seale, N. M., and S. Varghese. “Biomaterials for pluripotent stem cell engineering: From fate determination to vascularization.” Journal of Materials Chemistry B, vol. 4, no. 20, Jan. 2016, pp. 3454–63. Scopus, doi:10.1039/c5tb02658j.
Seale NM, Varghese S. Biomaterials for pluripotent stem cell engineering: From fate determination to vascularization. Journal of Materials Chemistry B. 2016 Jan 1;4(20):3454–3463.
Journal cover image

Published In

Journal of Materials Chemistry B

DOI

EISSN

2050-750X

ISSN

2050-7518

Publication Date

January 1, 2016

Volume

4

Issue

20

Start / End Page

3454 / 3463

Related Subject Headings

  • 4004 Chemical engineering
  • 4003 Biomedical engineering
  • 3403 Macromolecular and materials chemistry
  • 0903 Biomedical Engineering
  • 0303 Macromolecular and Materials Chemistry