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Computational Fluid Dynamics and Additive Manufacturing to Diagnose and Treat Cardiovascular Disease.

Publication ,  Journal Article
Randles, A; Frakes, DH; Leopold, JA
Published in: Trends in biotechnology
November 2017

Noninvasive engineering models are now being used for diagnosing and planning the treatment of cardiovascular disease. Techniques in computational modeling and additive manufacturing have matured concurrently, and results from simulations can inform and enable the design and optimization of therapeutic devices and treatment strategies. The emerging synergy between large-scale simulations and 3D printing is having a two-fold benefit: first, 3D printing can be used to validate the complex simulations, and second, the flow models can be used to improve treatment planning for cardiovascular disease. In this review, we summarize and discuss recent methods and findings for leveraging advances in both additive manufacturing and patient-specific computational modeling, with an emphasis on new directions in these fields and remaining open questions.

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Published In

Trends in biotechnology

DOI

EISSN

1879-3096

ISSN

0167-7799

Publication Date

November 2017

Volume

35

Issue

11

Start / End Page

1049 / 1061

Related Subject Headings

  • Models, Cardiovascular
  • Humans
  • Hemodynamics
  • Computer Simulation
  • Cardiovascular Diseases
  • Biotechnology
  • Animals
  • 3206 Medical biotechnology
  • 3106 Industrial biotechnology
  • 3001 Agricultural biotechnology
 

Citation

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Randles, A., Frakes, D. H., & Leopold, J. A. (2017). Computational Fluid Dynamics and Additive Manufacturing to Diagnose and Treat Cardiovascular Disease. Trends in Biotechnology, 35(11), 1049–1061. https://doi.org/10.1016/j.tibtech.2017.08.008
Randles, Amanda, David H. Frakes, and Jane A. Leopold. “Computational Fluid Dynamics and Additive Manufacturing to Diagnose and Treat Cardiovascular Disease.Trends in Biotechnology 35, no. 11 (November 2017): 1049–61. https://doi.org/10.1016/j.tibtech.2017.08.008.
Randles A, Frakes DH, Leopold JA. Computational Fluid Dynamics and Additive Manufacturing to Diagnose and Treat Cardiovascular Disease. Trends in biotechnology. 2017 Nov;35(11):1049–61.
Randles, Amanda, et al. “Computational Fluid Dynamics and Additive Manufacturing to Diagnose and Treat Cardiovascular Disease.Trends in Biotechnology, vol. 35, no. 11, Nov. 2017, pp. 1049–61. Epmc, doi:10.1016/j.tibtech.2017.08.008.
Randles A, Frakes DH, Leopold JA. Computational Fluid Dynamics and Additive Manufacturing to Diagnose and Treat Cardiovascular Disease. Trends in biotechnology. 2017 Nov;35(11):1049–1061.
Journal cover image

Published In

Trends in biotechnology

DOI

EISSN

1879-3096

ISSN

0167-7799

Publication Date

November 2017

Volume

35

Issue

11

Start / End Page

1049 / 1061

Related Subject Headings

  • Models, Cardiovascular
  • Humans
  • Hemodynamics
  • Computer Simulation
  • Cardiovascular Diseases
  • Biotechnology
  • Animals
  • 3206 Medical biotechnology
  • 3106 Industrial biotechnology
  • 3001 Agricultural biotechnology