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Neuropsychiatric signs and symptoms of Alzheimer's disease: New treatment paradigms

Publication ,  Journal Article
Lanctôt, KL; Amatniek, J; Ancoli-Israel, S; Arnold, SE; Ballard, C; Cohen-Mansfield, J; Ismail, Z; Lyketsos, C; Miller, DS; Musiek, E; Bain, LJ ...
Published in: Alzheimer's and Dementia: Translational Research and Clinical Interventions
September 1, 2017

Neuropsychiatric symptoms (NPSs) are hallmarks of Alzheimer's disease (AD), causing substantial distress for both people with dementia and their caregivers, and contributing to early institutionalization. They are among the earliest signs and symptoms of neurocognitive disorders and incipient cognitive decline, yet are under-recognized and often challenging to treat. With this in mind, the Alzheimer's Association convened a Research Roundtable in May 2016, bringing together experts from academia, industry, and regulatory agencies to discuss the latest understanding of NPSs and review the development of therapeutics and biomarkers of NPSs in AD. This review will explore the neurobiology of NPSs in AD and specific symptoms common in AD such as psychosis, agitation, apathy, depression, and sleep disturbances. In addition, clinical trial designs for NPSs in AD and regulatory considerations will be discussed.

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Published In

Alzheimer's and Dementia: Translational Research and Clinical Interventions

DOI

EISSN

2352-8737

Publication Date

September 1, 2017

Volume

3

Issue

3

Start / End Page

440 / 449

Related Subject Headings

  • 5202 Biological psychology
  • 3209 Neurosciences
  • 3202 Clinical sciences
 

Citation

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ICMJE
MLA
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Lanctôt, K. L., Amatniek, J., Ancoli-Israel, S., Arnold, S. E., Ballard, C., Cohen-Mansfield, J., … Boot, B. (2017). Neuropsychiatric signs and symptoms of Alzheimer's disease: New treatment paradigms. Alzheimer’s and Dementia: Translational Research and Clinical Interventions, 3(3), 440–449. https://doi.org/10.1016/j.trci.2017.07.001
Lanctôt, K. L., J. Amatniek, S. Ancoli-Israel, S. E. Arnold, C. Ballard, J. Cohen-Mansfield, Z. Ismail, et al. “Neuropsychiatric signs and symptoms of Alzheimer's disease: New treatment paradigms.” Alzheimer’s and Dementia: Translational Research and Clinical Interventions 3, no. 3 (September 1, 2017): 440–49. https://doi.org/10.1016/j.trci.2017.07.001.
Lanctôt KL, Amatniek J, Ancoli-Israel S, Arnold SE, Ballard C, Cohen-Mansfield J, et al. Neuropsychiatric signs and symptoms of Alzheimer's disease: New treatment paradigms. Alzheimer’s and Dementia: Translational Research and Clinical Interventions. 2017 Sep 1;3(3):440–9.
Lanctôt, K. L., et al. “Neuropsychiatric signs and symptoms of Alzheimer's disease: New treatment paradigms.” Alzheimer’s and Dementia: Translational Research and Clinical Interventions, vol. 3, no. 3, Sept. 2017, pp. 440–49. Scopus, doi:10.1016/j.trci.2017.07.001.
Lanctôt KL, Amatniek J, Ancoli-Israel S, Arnold SE, Ballard C, Cohen-Mansfield J, Ismail Z, Lyketsos C, Miller DS, Musiek E, Osorio RS, Rosenberg PB, Satlin A, Steffens D, Tariot P, Bain LJ, Carrillo MC, Hendrix JA, Jurgens H, Boot B. Neuropsychiatric signs and symptoms of Alzheimer's disease: New treatment paradigms. Alzheimer’s and Dementia: Translational Research and Clinical Interventions. 2017 Sep 1;3(3):440–449.
Journal cover image

Published In

Alzheimer's and Dementia: Translational Research and Clinical Interventions

DOI

EISSN

2352-8737

Publication Date

September 1, 2017

Volume

3

Issue

3

Start / End Page

440 / 449

Related Subject Headings

  • 5202 Biological psychology
  • 3209 Neurosciences
  • 3202 Clinical sciences