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Choroidal Changes After Suprachoroidal Injection of Triamcinolone Acetonide in Eyes With Macular Edema Secondary to Retinal Vein Occlusion.

Publication ,  Journal Article
Willoughby, AS; Vuong, VS; Cunefare, D; Farsiu, S; Noronha, G; Danis, RP; Yiu, G
Published in: American journal of ophthalmology
February 2018

To evaluate choroidal and suprachoroidal changes following suprachoroidal injection of triamcinolone acetonide injectable suspension (CLS-TA), in eyes with macular edema due to retinal vein occlusion (RVO).Prospective cohort study within a randomized, controlled phase 2 clinical trial.Enhanced depth imaging optical coherence tomography (EDI-OCT) images were analyzed from 38 eyes of 38 treatment-naïve patients with macular edema due to RVO, enrolled in the prospective Suprachoroidal Injection of Triamcinolone Acetonide with Intravitreal Aflibercept in Subjects with Macular Edema Due to Retinal Vein Occlusion (TANZANITE) study who received either a suprachoroidal injection of CLS-TA with an intravitreal injection of aflibercept (combination arm) or only an intravitreal injection of aflibercept (monotherapy arm), followed by monthly intravitreal aflibercept injections in both arms based on pro re nata criteria.Macular choroidal thickness measured to the outer choroidal vessel lumen (vascular choroidal thickness, VCT), outer choroid stroma (stromal choroidal thickness, SCT), or inner scleral border (total choroidal thickness, TCT) showed no significant changes over 3 months in both study arms (P = .231-.342). Eyes that received combination therapy showed a trend toward thickening of the suprachoroidal space (SCS) compared with monotherapy alone (13.4 μm vs 5.3 μm at 3 months; P = .077). In the 15 eyes that demonstrated a visible SCS at baseline, the SCS expanded significantly after suprachoroidal CLS-TA injection (16.2 μm to 27.8 μm at 3 months; P = .033).Suprachoroidal injection of CLS-TA does not alter choroidal thickness in eyes with macular edema due to RVO, but may result in expansion of the SCS.

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Published In

American journal of ophthalmology

DOI

EISSN

1879-1891

ISSN

0002-9394

Publication Date

February 2018

Volume

186

Start / End Page

144 / 151

Related Subject Headings

  • Visual Acuity
  • Triamcinolone Acetonide
  • Treatment Outcome
  • Tomography, Optical Coherence
  • Retinal Vein Occlusion
  • Recombinant Fusion Proteins
  • Receptors, Vascular Endothelial Growth Factor
  • Prospective Studies
  • Ophthalmology & Optometry
  • Middle Aged
 

Citation

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Willoughby, A. S., Vuong, V. S., Cunefare, D., Farsiu, S., Noronha, G., Danis, R. P., & Yiu, G. (2018). Choroidal Changes After Suprachoroidal Injection of Triamcinolone Acetonide in Eyes With Macular Edema Secondary to Retinal Vein Occlusion. American Journal of Ophthalmology, 186, 144–151. https://doi.org/10.1016/j.ajo.2017.11.020
Willoughby, Alex S., Vivian S. Vuong, David Cunefare, Sina Farsiu, Glenn Noronha, Ronald P. Danis, and Glenn Yiu. “Choroidal Changes After Suprachoroidal Injection of Triamcinolone Acetonide in Eyes With Macular Edema Secondary to Retinal Vein Occlusion.American Journal of Ophthalmology 186 (February 2018): 144–51. https://doi.org/10.1016/j.ajo.2017.11.020.
Willoughby AS, Vuong VS, Cunefare D, Farsiu S, Noronha G, Danis RP, et al. Choroidal Changes After Suprachoroidal Injection of Triamcinolone Acetonide in Eyes With Macular Edema Secondary to Retinal Vein Occlusion. American journal of ophthalmology. 2018 Feb;186:144–51.
Willoughby, Alex S., et al. “Choroidal Changes After Suprachoroidal Injection of Triamcinolone Acetonide in Eyes With Macular Edema Secondary to Retinal Vein Occlusion.American Journal of Ophthalmology, vol. 186, Feb. 2018, pp. 144–51. Epmc, doi:10.1016/j.ajo.2017.11.020.
Willoughby AS, Vuong VS, Cunefare D, Farsiu S, Noronha G, Danis RP, Yiu G. Choroidal Changes After Suprachoroidal Injection of Triamcinolone Acetonide in Eyes With Macular Edema Secondary to Retinal Vein Occlusion. American journal of ophthalmology. 2018 Feb;186:144–151.
Journal cover image

Published In

American journal of ophthalmology

DOI

EISSN

1879-1891

ISSN

0002-9394

Publication Date

February 2018

Volume

186

Start / End Page

144 / 151

Related Subject Headings

  • Visual Acuity
  • Triamcinolone Acetonide
  • Treatment Outcome
  • Tomography, Optical Coherence
  • Retinal Vein Occlusion
  • Recombinant Fusion Proteins
  • Receptors, Vascular Endothelial Growth Factor
  • Prospective Studies
  • Ophthalmology & Optometry
  • Middle Aged