Intervertebral Disc Degeneration Prevalence Risk Factors and Treatments
The pathophysiology of intervertebral disc disease
Publication
, Chapter
Boah, AO; Abu-Bonsrah, N; Goodwin, CR; Sciubba, DM
January 1, 2016
The degeneration of the intervertebral disc results from several multifactorial pathophysiologic processes. Here, we discuss the anatomy of the intervertebral disc along with a presentation of several pathologic processes including vascular insufficiency (possibly due to cigarette exposure and endothelial dysfunction), anatomic variations, poor nutritional status, infections, autoimmune and/or inflammatory processes, genetic predispositions and iatrogenic occurrences as well as exposure to drugs or toxins that lead to degeneration of the disc. This brief overview establishes a necessary starting point for the understanding of these processes as well as a preview into potential therapeutic targets.
Duke Scholars
Publication Date
January 1, 2016
Start / End Page
1 / 16
Citation
APA
Chicago
ICMJE
MLA
NLM
Boah, A. O., Abu-Bonsrah, N., Goodwin, C. R., & Sciubba, D. M. (2016). The pathophysiology of intervertebral disc disease. In Intervertebral Disc Degeneration Prevalence Risk Factors and Treatments (pp. 1–16).
Boah, A. O., N. Abu-Bonsrah, C. R. Goodwin, and D. M. Sciubba. “The pathophysiology of intervertebral disc disease.” In Intervertebral Disc Degeneration Prevalence Risk Factors and Treatments, 1–16, 2016.
Boah AO, Abu-Bonsrah N, Goodwin CR, Sciubba DM. The pathophysiology of intervertebral disc disease. In: Intervertebral Disc Degeneration Prevalence Risk Factors and Treatments. 2016. p. 1–16.
Boah, A. O., et al. “The pathophysiology of intervertebral disc disease.” Intervertebral Disc Degeneration Prevalence Risk Factors and Treatments, 2016, pp. 1–16.
Boah AO, Abu-Bonsrah N, Goodwin CR, Sciubba DM. The pathophysiology of intervertebral disc disease. Intervertebral Disc Degeneration Prevalence Risk Factors and Treatments. 2016. p. 1–16.
Publication Date
January 1, 2016
Start / End Page
1 / 16