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Intervertebral Disc Degeneration: Prevalence, Risk Factors and Treatments

The pathophysiology of intervertebral disc disease

Publication ,  Chapter
Boah, AO; Abu-Bonsrah, N; Goodwin, CR; Sciubba, DM
January 1, 2016

The degeneration of the intervertebral disc results from several multifactorial pathophysiologic processes. Here, we discuss the anatomy of the intervertebral disc along with a presentation of several pathologic processes including vascular insufficiency (possibly due to cigarette exposure and endothelial dysfunction), anatomic variations, poor nutritional status, infections, autoimmune and/or inflammatory processes, genetic predispositions and iatrogenic occurrences as well as exposure to drugs or toxins that lead to degeneration of the disc. This brief overview establishes a necessary starting point for the understanding of these processes as well as a preview into potential therapeutic targets.

Duke Scholars

ISBN

9781634858298

Publication Date

January 1, 2016

Start / End Page

1 / 16
 

Citation

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MLA
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Boah, A. O., Abu-Bonsrah, N., Goodwin, C. R., & Sciubba, D. M. (2016). The pathophysiology of intervertebral disc disease. In Intervertebral Disc Degeneration: Prevalence, Risk Factors and Treatments (pp. 1–16).
Boah, A. O., N. Abu-Bonsrah, C. R. Goodwin, and D. M. Sciubba. “The pathophysiology of intervertebral disc disease.” In Intervertebral Disc Degeneration: Prevalence, Risk Factors and Treatments, 1–16, 2016.
Boah AO, Abu-Bonsrah N, Goodwin CR, Sciubba DM. The pathophysiology of intervertebral disc disease. In: Intervertebral Disc Degeneration: Prevalence, Risk Factors and Treatments. 2016. p. 1–16.
Boah, A. O., et al. “The pathophysiology of intervertebral disc disease.” Intervertebral Disc Degeneration: Prevalence, Risk Factors and Treatments, 2016, pp. 1–16.
Boah AO, Abu-Bonsrah N, Goodwin CR, Sciubba DM. The pathophysiology of intervertebral disc disease. Intervertebral Disc Degeneration: Prevalence, Risk Factors and Treatments. 2016. p. 1–16.
Journal cover image

ISBN

9781634858298

Publication Date

January 1, 2016

Start / End Page

1 / 16