Skip to main content
Journal cover image

Functional Modification of Silica through Enhanced Adsorption of Elastin-Like Polypeptide Block Copolymers.

Publication ,  Journal Article
Li, L; Li, NK; Tu, Q; Im, O; Mo, C-K; Han, W; Fuss, WH; Carroll, NJ; Chilkoti, A; Yingling, YG; Zauscher, S; López, GP
Published in: Biomacromolecules
February 2018

A powerful tool for controlling interfacial properties and molecular architecture relies on the tailored adsorption of stimuli-responsive block copolymers onto surfaces. Here, we use computational and experimental approaches to investigate the adsorption behavior of thermally responsive polypeptide block copolymers (elastin-like polypeptides, ELPs) onto silica surfaces, and to explore the effects of surface affinity and micellization on the adsorption kinetics and the resultant polypeptide layers. We demonstrate that genetic incorporation of a silica-binding peptide (silaffin R5) results in enhanced adsorption of these block copolymers onto silica surfaces as measured by quartz crystal microbalance and ellipsometry. We find that the silaffin peptide can also direct micelle adsorption, leading to close-packed micellar arrangements that are distinct from the sparse, patchy arrangements observed for ELP micelles lacking a silaffin tag, as evidenced by atomic force microscopy measurements. These experimental findings are consistent with results of dissipative particle dynamics simulations. Wettability measurements suggest that surface immobilization hampers the temperature-dependent conformational change of ELP micelles, while adsorbed ELP unimers (i.e., unmicellized block copolymers) retain their thermally responsive property at interfaces. These observations provide guidance on the use of ELP block copolymers as building blocks for fabricating smart surfaces and interfaces with programmable architecture and functionality.

Duke Scholars

Published In

Biomacromolecules

DOI

EISSN

1526-4602

ISSN

1525-7797

Publication Date

February 2018

Volume

19

Issue

2

Start / End Page

298 / 306

Related Subject Headings

  • Wettability
  • Silicon Dioxide
  • Protein Precursors
  • Polymers
  • Peptide Fragments
  • Molecular Dynamics Simulation
  • Micelles
  • Elastin
  • Adsorption
  • 40 Engineering
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Li, L., Li, N. K., Tu, Q., Im, O., Mo, C.-K., Han, W., … López, G. P. (2018). Functional Modification of Silica through Enhanced Adsorption of Elastin-Like Polypeptide Block Copolymers. Biomacromolecules, 19(2), 298–306. https://doi.org/10.1021/acs.biomac.7b01307
Li, Linying, Nan K. Li, Qing Tu, Owen Im, Chia-Kuei Mo, Wei Han, William H. Fuss, et al. “Functional Modification of Silica through Enhanced Adsorption of Elastin-Like Polypeptide Block Copolymers.Biomacromolecules 19, no. 2 (February 2018): 298–306. https://doi.org/10.1021/acs.biomac.7b01307.
Li L, Li NK, Tu Q, Im O, Mo C-K, Han W, et al. Functional Modification of Silica through Enhanced Adsorption of Elastin-Like Polypeptide Block Copolymers. Biomacromolecules. 2018 Feb;19(2):298–306.
Li, Linying, et al. “Functional Modification of Silica through Enhanced Adsorption of Elastin-Like Polypeptide Block Copolymers.Biomacromolecules, vol. 19, no. 2, Feb. 2018, pp. 298–306. Epmc, doi:10.1021/acs.biomac.7b01307.
Li L, Li NK, Tu Q, Im O, Mo C-K, Han W, Fuss WH, Carroll NJ, Chilkoti A, Yingling YG, Zauscher S, López GP. Functional Modification of Silica through Enhanced Adsorption of Elastin-Like Polypeptide Block Copolymers. Biomacromolecules. 2018 Feb;19(2):298–306.
Journal cover image

Published In

Biomacromolecules

DOI

EISSN

1526-4602

ISSN

1525-7797

Publication Date

February 2018

Volume

19

Issue

2

Start / End Page

298 / 306

Related Subject Headings

  • Wettability
  • Silicon Dioxide
  • Protein Precursors
  • Polymers
  • Peptide Fragments
  • Molecular Dynamics Simulation
  • Micelles
  • Elastin
  • Adsorption
  • 40 Engineering