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Spin Relays Enable Efficient Long-Range Heteronuclear Signal Amplification By Reversible Exchange.

Publication ,  Journal Article
Shchepin, RV; Jaigirdar, L; Theis, T; Warren, WS; Goodson, BM; Chekmenev, EY
Published in: The journal of physical chemistry. C, Nanomaterials and interfaces
December 2017

A systematic experimental study is reported on the polarization transfer to distant spins, which do not directly bind to the polarization transfer complexes employed in Signal Amplification By Reversible Exchange (SABRE) experiments. Both, long-range transfer to protons and long-range transfer to heteronuclei i.e. 13C and 15N are examined. Selective destruction of hyperpolarization on 1H, 13C, and 15N sites is employed, followed by their re-hyperpolarization from neighboring spins within the molecules of interest (pyridine for 1H studies and metronidazole-15N2-13C2 for 13C and 15N studies). We conclude that long-range sites can be efficiently hyperpolarized when a network of spin-½ nuclei enables relayed polarization transfer (i.e. via short-range interactions between sites). In case of proton SABRE in the milli-Tesla regime, a relay network consisting of protons only is sufficient. However, in case 13C and 15N are targeted (i.e. via SABRE in SHield Enables Alignment Transfer to Heteronuclei or SABRE-SHEATH experiment), the presence of a heteronuclear network (e.g. consisting of 15N) enables a relay mechanism that is significantly more efficient than the direct transfer of spin order from para-H2-derived hydrides.

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Published In

The journal of physical chemistry. C, Nanomaterials and interfaces

DOI

EISSN

1932-7455

ISSN

1932-7447

Publication Date

December 2017

Volume

121

Issue

51

Start / End Page

28425 / 28434

Related Subject Headings

  • Physical Chemistry
  • 40 Engineering
  • 34 Chemical sciences
  • 10 Technology
  • 09 Engineering
  • 03 Chemical Sciences
 

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Shchepin, R. V., Jaigirdar, L., Theis, T., Warren, W. S., Goodson, B. M., & Chekmenev, E. Y. (2017). Spin Relays Enable Efficient Long-Range Heteronuclear Signal Amplification By Reversible Exchange. The Journal of Physical Chemistry. C, Nanomaterials and Interfaces, 121(51), 28425–28434. https://doi.org/10.1021/acs.jpcc.7b11485
Shchepin, Roman V., Lamya Jaigirdar, Thomas Theis, Warren S. Warren, Boyd M. Goodson, and Eduard Y. Chekmenev. “Spin Relays Enable Efficient Long-Range Heteronuclear Signal Amplification By Reversible Exchange.The Journal of Physical Chemistry. C, Nanomaterials and Interfaces 121, no. 51 (December 2017): 28425–34. https://doi.org/10.1021/acs.jpcc.7b11485.
Shchepin RV, Jaigirdar L, Theis T, Warren WS, Goodson BM, Chekmenev EY. Spin Relays Enable Efficient Long-Range Heteronuclear Signal Amplification By Reversible Exchange. The journal of physical chemistry C, Nanomaterials and interfaces. 2017 Dec;121(51):28425–34.
Shchepin, Roman V., et al. “Spin Relays Enable Efficient Long-Range Heteronuclear Signal Amplification By Reversible Exchange.The Journal of Physical Chemistry. C, Nanomaterials and Interfaces, vol. 121, no. 51, Dec. 2017, pp. 28425–34. Epmc, doi:10.1021/acs.jpcc.7b11485.
Shchepin RV, Jaigirdar L, Theis T, Warren WS, Goodson BM, Chekmenev EY. Spin Relays Enable Efficient Long-Range Heteronuclear Signal Amplification By Reversible Exchange. The journal of physical chemistry C, Nanomaterials and interfaces. 2017 Dec;121(51):28425–28434.
Journal cover image

Published In

The journal of physical chemistry. C, Nanomaterials and interfaces

DOI

EISSN

1932-7455

ISSN

1932-7447

Publication Date

December 2017

Volume

121

Issue

51

Start / End Page

28425 / 28434

Related Subject Headings

  • Physical Chemistry
  • 40 Engineering
  • 34 Chemical sciences
  • 10 Technology
  • 09 Engineering
  • 03 Chemical Sciences