Brenner's Encyclopedia of Genetics: Second Edition
Nondisjunction
Publication
, Chapter
Sullivan, BA
February 27, 2013
Accurate chromosome segregation during cell division is essential for the health and viability of cells and organisms. Duplicated chromosomes attach to microtubules and subsequently disjoin to be equally partitioned to daughter cells. Failure to evenly apportion chromosomes is called nondisjunction and leads to aneuploidy, or a change in chromosome number. Abnormal chromosome number is associated with birth defects, mental retardation, reproductive defects, and cancer. This article draws upon recent studies in humans and model organisms to both define nondisjunction and discuss its molecular basis.
Duke Scholars
DOI
ISBN
9780123749840
Publication Date
February 27, 2013
Start / End Page
90 / 93
Citation
APA
Chicago
ICMJE
MLA
NLM
Sullivan, B. A. (2013). Nondisjunction. In Brenner’s Encyclopedia of Genetics: Second Edition (pp. 90–93). https://doi.org/10.1016/B978-0-12-374984-0.01056-1
Sullivan, B. A. “Nondisjunction.” In Brenner’s Encyclopedia of Genetics: Second Edition, 90–93, 2013. https://doi.org/10.1016/B978-0-12-374984-0.01056-1.
Sullivan BA. Nondisjunction. In: Brenner’s Encyclopedia of Genetics: Second Edition. 2013. p. 90–3.
Sullivan, B. A. “Nondisjunction.” Brenner’s Encyclopedia of Genetics: Second Edition, 2013, pp. 90–93. Scopus, doi:10.1016/B978-0-12-374984-0.01056-1.
Sullivan BA. Nondisjunction. Brenner’s Encyclopedia of Genetics: Second Edition. 2013. p. 90–93.
DOI
ISBN
9780123749840
Publication Date
February 27, 2013
Start / End Page
90 / 93