Spatial localization of the Ebola virus glycoprotein mucin-like domain determined by cryo-electron tomography.
Publication
, Journal Article
Tran, EEH; Simmons, JA; Bartesaghi, A; Shoemaker, CJ; Nelson, E; White, JM; Subramaniam, S
Published in: Journal of virology
September 2014
The Ebola virus glycoprotein mucin-like domain (MLD) is implicated in Ebola virus cell entry and immune evasion. Using cryo-electron tomography of Ebola virus-like particles, we determined a three-dimensional structure for the full-length glycoprotein in a near-native state and compared it to that of a glycoprotein lacking the MLD. Our results, which show that the MLD is located at the apex and the sides of each glycoprotein monomer, provide a structural template for analysis of MLD function.
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Published In
Journal of virology
DOI
EISSN
1098-5514
ISSN
0022-538X
Publication Date
September 2014
Volume
88
Issue
18
Start / End Page
10958 / 10962
Related Subject Headings
- Virology
- Viral Envelope Proteins
- Protein Structure, Tertiary
- Models, Molecular
- Humans
- Hemorrhagic Fever, Ebola
- Ebolavirus
- Cryoelectron Microscopy
- 32 Biomedical and clinical sciences
- 31 Biological sciences
Citation
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Chicago
ICMJE
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Tran, E. E. H., Simmons, J. A., Bartesaghi, A., Shoemaker, C. J., Nelson, E., White, J. M., & Subramaniam, S. (2014). Spatial localization of the Ebola virus glycoprotein mucin-like domain determined by cryo-electron tomography. Journal of Virology, 88(18), 10958–10962. https://doi.org/10.1128/jvi.00870-14
Tran, Erin E. H., James A. Simmons, Alberto Bartesaghi, Charles J. Shoemaker, Elizabeth Nelson, Judith M. White, and Sriram Subramaniam. “Spatial localization of the Ebola virus glycoprotein mucin-like domain determined by cryo-electron tomography.” Journal of Virology 88, no. 18 (September 2014): 10958–62. https://doi.org/10.1128/jvi.00870-14.
Tran EEH, Simmons JA, Bartesaghi A, Shoemaker CJ, Nelson E, White JM, et al. Spatial localization of the Ebola virus glycoprotein mucin-like domain determined by cryo-electron tomography. Journal of virology. 2014 Sep;88(18):10958–62.
Tran, Erin E. H., et al. “Spatial localization of the Ebola virus glycoprotein mucin-like domain determined by cryo-electron tomography.” Journal of Virology, vol. 88, no. 18, Sept. 2014, pp. 10958–62. Epmc, doi:10.1128/jvi.00870-14.
Tran EEH, Simmons JA, Bartesaghi A, Shoemaker CJ, Nelson E, White JM, Subramaniam S. Spatial localization of the Ebola virus glycoprotein mucin-like domain determined by cryo-electron tomography. Journal of virology. 2014 Sep;88(18):10958–10962.
Published In
Journal of virology
DOI
EISSN
1098-5514
ISSN
0022-538X
Publication Date
September 2014
Volume
88
Issue
18
Start / End Page
10958 / 10962
Related Subject Headings
- Virology
- Viral Envelope Proteins
- Protein Structure, Tertiary
- Models, Molecular
- Humans
- Hemorrhagic Fever, Ebola
- Ebolavirus
- Cryoelectron Microscopy
- 32 Biomedical and clinical sciences
- 31 Biological sciences