Alberto Bartesaghi | Scholars@Duke

Alberto Bartesaghi
Associate Professor of Computer Science

Current Research Interests

Image analysis, data science, computer vision, machine learning, image reconstruction, cryo-electron microscopy, protein structure

Current Appointments & Affiliations

Associate Professor of Computer Science, Computer Science, Trinity College of Arts & Sciences 2018
Associate Professor of Biochemistry, Biochemistry, Basic Science Departments 2018
Associate Professor in the Department of Electrical and Computer Engineering, Electrical and Computer Engineering, Pratt School of Engineering 2018
Faculty Network Member of the Duke Institute for Brain Sciences, Duke Institute for Brain Sciences, University Institutes and Centers 2018

Contact Information

308 Research Drive, LSRC D338, Durham, NC 27708-0129
alberto.bartesaghi@duke.edu (919) 660-6579
cryoem.cs.duke.edu

Background
Education, Training, & Certifications
- D.Phil., University of Minnesota, Twin Cities 2005
Duke Appointment History
- Scholar In Residence of Computer Science, Computer Science, Trinity College of Arts & Sciences 2018
Recognition
In the News
- APR 6, 2021
  
  Duke Team Makes Cryo-EM Microscope Even Better Than Before
- MAR 5, 2021
  
  Duke & UNC: Rivals on the Court, Teammates in Science
Research
Selected Grants
- Molecular elucidation of the Francisella tularensis virulence mechanism awarded by National Institutes of Health 2021 - 2026
- Structures of initial CD4 engagement with pre-fusion, closed HIV-1 Envelope trimer and early CD4-induced conformational changes required for infection awarded by National Institutes of Health 2019 - 2024
- Structural studies of virulence activation in Francisella tularensis awarded by National Institutes of Health 2020 - 2023
- Cryo-EM Investigation of Protein Structures awarded by Syngenta Corp Protection, LLC 2021 - 2022
- Structural Elucidation of the Novel RNA Polymerase Underlying Francisella Tularensis Virulence awarded by National Institutes of Health 2020 - 2022
- Bioinformatics and Computational Biology Training Program awarded by National Institutes of Health 2005 - 2021
- Structural Analysis of Env During HIV-1 Maturation Using In-situ Cryo-electron Tomography awarded by National Institute of Environmental Health Sciences 2019 - 2020
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Williams, Wilton B., R Ryan Meyerhoff, R. J. Edwards, Hui Li, Kartik Manne, Nathan I. Nicely, Rory Henderson, et al. “Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies.” Cell 184, no. 11 (May 27, 2021): 2955-2972.e25. https://doi.org/10.1016/j.cell.2021.04.042.
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  - Bouvette, Jonathan, Hsuan-Fu Liu, Xiaochen Du, Ye Zhou, Andrew P. Sikkema, Juliana da Fonseca Rezende E Mello, Bradley P. Klemm, et al. “Beam image-shift accelerated data acquisition for near-atomic resolution single-particle cryo-electron tomography.” Nat Commun 12, no. 1 (March 30, 2021): 1957. https://doi.org/10.1038/s41467-021-22251-8.
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  - Travis, Brady A., Kathryn M. Ramsey, Samantha M. Prezioso, Thomas Tallo, Jamie M. Wandzilak, Allen Hsu, Mario Borgnia, et al. “Structural Basis for Virulence Activation of Francisella tularensis.” Mol Cell 81, no. 1 (January 7, 2021): 139-152.e10. https://doi.org/10.1016/j.molcel.2020.10.035.
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  - Zhou, Ye, Panagiotis L. Kastritis, Shannon E. Dougherty, Jonathan Bouvette, Allen L. Hsu, Laura Burbaum, Shyamal Mosalaganti, et al. “Structural impact of K63 ubiquitin on yeast translocating ribosomes under oxidative stress.” Proc Natl Acad Sci U S A 117, no. 36 (September 8, 2020): 22157–66. https://doi.org/10.1073/pnas.2005301117.
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  - Bendory, Tamir, Alberto Bartesaghi, and Amit Singer. “Single-particle cryo-electron microscopy: Mathematical theory, computational challenges, and opportunities.” Ieee Signal Processing Magazine 37, no. 2 (March 2020): 58–76. https://doi.org/10.1109/msp.2019.2957822.
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  - Henderson, Rory, Maolin Lu, Ye Zhou, Zekun Mu, Robert Parks, Qifeng Han, Allen L. Hsu, et al. “Disruption of the HIV-1 Envelope allosteric network blocks CD4-induced rearrangements.” Nat Commun 11, no. 1 (January 24, 2020): 520. https://doi.org/10.1038/s41467-019-14196-w.
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  - Bendory, Tamir, Alberto Bartesaghi, and Amit Singer. “Single-Particle Cryo-Electron Microscopy: Mathematical Theory, Computational Challenges, and Opportunities.” Ieee Signal Process. Mag. 37 (2020): 58–76.
  - Huang, Qinwen, Ye Zhou, Xiaochen Du, Reed Chen, Jianyou Wang, Cynthia Rudin, and Alberto Bartesaghi. “Cryo-ZSSR: multiple-image super-resolution based on deep internal learning.” Corr abs/2011.11020 (2020).
  - Zhou, Y., A. Moscovich, T. Bendory, and A. Bartesaghi. “Unsupervised particle sorting for high-resolution single-particle cryo-EM.” Inverse Problems 36, no. 4 (January 1, 2020). https://doi.org/10.1088/1361-6420/ab5ec8.
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  - Aguerrebere, C., M. Delbracio, A. Bartesaghi, and G. Sapiro. “A Practical Guide to Multi-Image Alignment.” Icassp, Ieee International Conference on Acoustics, Speech and Signal Processing Proceedings 2018-April (September 10, 2018): 1927–31. https://doi.org/10.1109/ICASSP.2018.8461588.
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  - Kang, Yanyong, Oleg Kuybeda, Parker W. de Waal, Somnath Mukherjee, Ned Van Eps, Przemyslaw Dutka, X Edward Zhou, et al. “Publisher Correction: Cryo-EM structure of human rhodopsin bound to an inhibitory G protein.” Nature 561, no. 7724 (September 2018): E44. https://doi.org/10.1038/s41586-018-0302-0.
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  - Matthies, Doreen, Chanhyung Bae, Gilman Es Toombes, Tara Fox, Alberto Bartesaghi, Sriram Subramaniam, and Kenton Jon Swartz. “Single-particle cryo-EM structure of a voltage-activated potassium channel in lipid nanodiscs.” Elife 7 (August 15, 2018). https://doi.org/10.7554/elife.37558.
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  - Kang, Yanyong, Oleg Kuybeda, Parker W. de Waal, Somnath Mukherjee, Ned Van Eps, Przemyslaw Dutka, X Edward Zhou, et al. “Cryo-EM structure of human rhodopsin bound to an inhibitory G protein.” Nature 558, no. 7711 (June 13, 2018): 553–58. https://doi.org/10.1038/s41586-018-0215-y.
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  - Bartesaghi, Alberto, Cecilia Aguerrebere, Veronica Falconieri, Soojay Banerjee, Lesley A. Earl, Xing Zhu, Nikolaus Grigorieff, et al. “Atomic Resolution Cryo-EM Structure of β-Galactosidase.” Structure (London, England : 1993) 26, no. 6 (June 2018): 848-856.e3. https://doi.org/10.1016/j.str.2018.04.004.
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  - Guo, Tai Wei, Alberto Bartesaghi, Hui Yang, Veronica Falconieri, Prashant Rao, Alan Merk, Edward T. Eng, et al. “Cryo-EM Structures Reveal Mechanism and Inhibition of DNA Targeting by a CRISPR-Cas Surveillance Complex.” Cell 171, no. 2 (October 2017): 414-426.e12. https://doi.org/10.1016/j.cell.2017.09.006.
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  - Aguerrebere, C., M. Delbracio, A. Bartesaghi, and G. Sapiro. “Fundamental limits in multi-image alignment.” Ieee Transactions on Signal Processing 64, no. 21 (November 1, 2016): 5707–22. https://doi.org/10.1109/TSP.2016.2600517.
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  - Frank, Gabriel A., Suneet Shukla, Prashant Rao, Mario J. Borgnia, Alberto Bartesaghi, Alan Merk, Aerfa Mobin, et al. “Cryo-EM Analysis of the Conformational Landscape of Human P-glycoprotein (ABCB1) During its Catalytic Cycle.” Mol Pharmacol 90, no. 1 (July 2016): 35–41. https://doi.org/10.1124/mol.116.104190.
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  - Borgnia, Mario J., Soojay Banerjee, Alan Merk, Doreen Matthies, Alberto Bartesaghi, Prashant Rao, Jason Pierson, et al. “Using Cryo-EM to Map Small Ligands on Dynamic Metabolic Enzymes: Studies with Glutamate Dehydrogenase.” Mol Pharmacol 89, no. 6 (June 2016): 645–51. https://doi.org/10.1124/mol.116.103382.
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  - Merk, Alan, Alberto Bartesaghi, Soojay Banerjee, Veronica Falconieri, Prashant Rao, Mindy I. Davis, Rajan Pragani, et al. “Breaking Cryo-EM Resolution Barriers to Facilitate Drug Discovery.” Cell 165, no. 7 (June 2016): 1698–1707. https://doi.org/10.1016/j.cell.2016.05.040.
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  - Tran, Erin E. H., Kira A. Podolsky, Alberto Bartesaghi, Oleg Kuybeda, Giovanna Grandinetti, Teddy John Wohlbold, Gene S. Tan, et al. “Cryo-electron Microscopy Structures of Chimeric Hemagglutinin Displayed on a Universal Influenza Vaccine Candidate.” Mbio 7, no. 2 (March 22, 2016): e00257. https://doi.org/10.1128/mbio.00257-16.
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  - Matthies, Doreen, Olivier Dalmas, Mario J. Borgnia, Pawel K. Dominik, Alan Merk, Prashant Rao, Bharat G. Reddy, et al. “Cryo-EM Structures of the Magnesium Channel CorA Reveal Symmetry Break upon Gating.” Cell 164, no. 4 (February 11, 2016): 747–56. https://doi.org/10.1016/j.cell.2015.12.055.
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  - Banerjee, Soojay, Alberto Bartesaghi, Alan Merk, Prashant Rao, Stacie L. Bulfer, Yongzhao Yan, Neal Green, et al. “2.3 Å resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition.” Science (New York, N.Y.) 351, no. 6275 (February 2016): 871–75. https://doi.org/10.1126/science.aad7974.
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  - Aguerrebere, Cecilia, Mauricio Delbracio, Alberto Bartesaghi, and Guillermo Sapiro. “Fundamental Limits in Multi-Image Alignment.” Ieee Trans. Signal Process. 64 (2016): 5707–22.
  - Bartesaghi, Alberto, Alan Merk, Soojay Banerjee, Doreen Matthies, Xiongwu Wu, Jacqueline L. S. Milne, and Sriram Subramaniam. “2.2 Å resolution cryo-EM structure of β-galactosidase in complex with a cell-permeant inhibitor.” Science (New York, N.Y.) 348, no. 6239 (June 2015): 1147–51. https://doi.org/10.1126/science.aab1576.
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  - Meyerson, Joel R., Janesh Kumar, Sagar Chittori, Prashant Rao, Jason Pierson, Alberto Bartesaghi, Mark L. Mayer, and Sriram Subramaniam. “Structural mechanism of glutamate receptor activation and desensitization.” Nature 514, no. 7522 (October 2014): 328–34. https://doi.org/10.1038/nature13603.
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  - Tran, Erin E. H., James A. Simmons, Alberto Bartesaghi, Charles J. Shoemaker, Elizabeth Nelson, Judith M. White, and Sriram Subramaniam. “Spatial localization of the Ebola virus glycoprotein mucin-like domain determined by cryo-electron tomography.” Journal of Virology 88, no. 18 (September 2014): 10958–62. https://doi.org/10.1128/jvi.00870-14.
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  - Bartesaghi, Alberto, Doreen Matthies, Soojay Banerjee, Alan Merk, and Sriram Subramaniam. “Structure of β-galactosidase at 3.2-Å resolution obtained by cryo-electron microscopy.” Proceedings of the National Academy of Sciences of the United States of America 111, no. 32 (August 2014): 11709–14. https://doi.org/10.1073/pnas.1402809111.
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  - Bartesaghi, Alberto, Alan Merk, Mario J. Borgnia, Jacqueline L. S. Milne, and Sriram Subramaniam. “Prefusion structure of trimeric HIV-1 envelope glycoprotein determined by cryo-electron microscopy.” Nat Struct Mol Biol 20, no. 12 (December 2013): 1352–57. https://doi.org/10.1038/nsmb.2711.
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  - Harris, Audray K., Alberto Bartesaghi, Jacqueline L. S. Milne, and Sriram Subramaniam. “HIV-1 envelope glycoprotein trimers display open quaternary conformation when bound to the gp41 membrane-proximal external-region-directed broadly neutralizing antibody Z13e1.” Journal of Virology 87, no. 12 (June 2013): 7191–96. https://doi.org/10.1128/jvi.03284-12.
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  - Schauder, David M., Oleg Kuybeda, Jinjin Zhang, Katherine Klymko, Alberto Bartesaghi, Mario J. Borgnia, Mark L. Mayer, and Sriram Subramaniam. “Glutamate receptor desensitization is mediated by changes in quaternary structure of the ligand binding domain.” Proc Natl Acad Sci U S A 110, no. 15 (April 9, 2013): 5921–26. https://doi.org/10.1073/pnas.1217549110.
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  - Kuybeda, Oleg, Gabriel A. Frank, Alberto Bartesaghi, Mario Borgnia, Sriram Subramaniam, and Guillermo Sapiro. “A collaborative framework for 3D alignment and classification of heterogeneous subvolumes in cryo-electron tomography.” J Struct Biol 181, no. 2 (February 2013): 116–27. https://doi.org/10.1016/j.jsb.2012.10.010.
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  - Milne, Jacqueline L. S., Mario J. Borgnia, Alberto Bartesaghi, Erin E. H. Tran, Lesley A. Earl, David M. Schauder, Jeffrey Lengyel, Jason Pierson, Ardan Patwardhan, and Sriram Subramaniam. “Cryo-electron microscopy--a primer for the non-microscopist.” Febs J 280, no. 1 (January 2013): 28–45. https://doi.org/10.1111/febs.12078.
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  - Bartesaghi, Alberto, Federico Lecumberry, Guillermo Sapiro, and Sriram Subramaniam. “Protein secondary structure determination by constrained single-particle cryo-electron tomography.” Structure (London, England : 1993) 20, no. 12 (December 2012): 2003–13. https://doi.org/10.1016/j.str.2012.10.016.
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  - Frank, Gabriel A., Alberto Bartesaghi, Oleg Kuybeda, Mario J. Borgnia, Tommi A. White, Guillermo Sapiro, and Sriram Subramaniam. “Computational separation of conformational heterogeneity using cryo-electron tomography and 3D sub-volume averaging.” J Struct Biol 178, no. 2 (May 2012): 165–76. https://doi.org/10.1016/j.jsb.2012.01.004.
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  - Tran, Erin E. H., Mario J. Borgnia, Oleg Kuybeda, David M. Schauder, Alberto Bartesaghi, Gabriel A. Frank, Guillermo Sapiro, Jacqueline L. S. Milne, and Sriram Subramaniam. “Structural mechanism of trimeric HIV-1 envelope glycoprotein activation.” Plos Pathog 8, no. 7 (2012): e1002797. https://doi.org/10.1371/journal.ppat.1002797.
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  - Meyerson, Joel R., Tommi A. White, Donald Bliss, Amy Moran, Alberto Bartesaghi, Mario J. Borgnia, M Jason V. de la Cruz, et al. “Determination of molecular structures of HIV envelope glycoproteins using cryo-electron tomography and automated sub-tomogram averaging.” J Vis Exp, no. 58 (December 1, 2011). https://doi.org/10.3791/2770.
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  - White, Tommi A., Alberto Bartesaghi, Mario J. Borgnia, M Jason V. de la Cruz, Rachna Nandwani, James A. Hoxie, Julian W. Bess, Jeffrey D. Lifson, Jacqueline L. S. Milne, and Sriram Subramaniam. “Three-dimensional structures of soluble CD4-bound states of trimeric simian immunodeficiency virus envelope glycoproteins determined by using cryo-electron tomography.” J Virol 85, no. 23 (December 2011): 12114–23. https://doi.org/10.1128/JVI.05297-11.
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  - Harris, Audray, Mario J. Borgnia, Dan Shi, Alberto Bartesaghi, Haifeng He, Robert Pejchal, Yun Kenneth Kang, et al. “Trimeric HIV-1 glycoprotein gp140 immunogens and native HIV-1 envelope glycoproteins display the same closed and open quaternary molecular architectures.” Proc Natl Acad Sci U S A 108, no. 28 (July 12, 2011): 11440–45. https://doi.org/10.1073/pnas.1101414108.
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  - White, Tommi A., Alberto Bartesaghi, Mario J. Borgnia, Joel R. Meyerson, M Jason V. de la Cruz, Julian W. Bess, Rachna Nandwani, et al. “Molecular architectures of trimeric SIV and HIV-1 envelope glycoproteins on intact viruses: strain-dependent variation in quaternary structure.” Plos Pathog 6, no. 12 (December 23, 2010): e1001249. https://doi.org/10.1371/journal.ppat.1001249.
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  - Bartesaghi, Alberto, and Sriram Subramaniam. “Membrane protein structure determination using cryo-electron tomography and 3D image averaging.” Current Opinion in Structural Biology 19, no. 4 (August 2009): 402–7. https://doi.org/10.1016/j.sbi.2009.06.005.
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  - Liu, Jun, Alberto Bartesaghi, Mario J. Borgnia, Guillermo Sapiro, and Sriram Subramaniam. “Molecular architecture of native HIV-1 gp120 trimers.” Nature 455, no. 7209 (September 4, 2008): 109–13. https://doi.org/10.1038/nature07159.
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  - Bartesaghi, A., P. Sprechmann, J. Liu, G. Randall, G. Sapiro, and S. Subramaniam. “Classification and 3D averaging with missing wedge correction in biological electron tomography.” Journal of Structural Biology 162, no. 3 (June 2008): 436–50. https://doi.org/10.1016/j.jsb.2008.02.008.
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  - Liu, J., A. Bartesaghi, M. J. Borgnia, G. Sapiro, and S. Subramaniam. “Molecular Architecture of Native HIV-1 gp 120 Trimers.” Chemtracts 21, no. 6 (June 1, 2008): 227–28.
  - Aganj, I., A. Bartesaghi, M. Borgnia, H. Y. Liao, G. Sapiro, and S. Subramaniam. “Regularization for inverting the radon transform with wedge consideration.” 2007 4th Ieee International Symposium on Biomedical Imaging: From Nano to Macro Proceedings, November 27, 2007, 217–20. https://doi.org/10.1109/ISBI.2007.356827.
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  - Bartesaghi, A., P. Sprechmann, G. Randall, G. Sapiro, and S. Subramaniam. “Classification, averaging and reconstruction of macromolecules in electron tomography.” 2007 4th Ieee International Symposium on Biomedical Imaging: From Nano to Macro Proceedings, November 27, 2007, 244–47. https://doi.org/10.1109/ISBI.2007.356834.
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  - Subramaniam, Sriram, Alberto Bartesaghi, Jun Liu, Adam E. Bennett, and Rachid Sougrat. “Electron tomography of viruses.” Current Opinion in Structural Biology 17, no. 5 (October 25, 2007): 596–602. https://doi.org/10.1016/j.sbi.2007.09.009.
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  - Bartesaghi, A. “Omet opens the debate on today's packaging revolution.” Folding Carton Industry 34, no. 3 (May 1, 2007): 32–34.
  - Sougrat, Rachid, Alberto Bartesaghi, Jeffrey D. Lifson, Adam E. Bennett, Julian W. Bess, Daniel J. Zabransky, and Sriram Subramaniam. “Electron tomography of the contact between T cells and SIV/HIV-1: implications for viral entry.” Plos Pathogens 3, no. 5 (May 2007): e63. https://doi.org/10.1371/journal.ppat.0030063.
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  - Yatziv, L., A. Bartesaghi, and G. Sapiro. “O(N) implementation of the fast marching algorithm.” Journal of Computational Physics 212, no. 2 (March 1, 2006): 393–99. https://doi.org/10.1016/j.jcp.2005.08.005.
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  - Mohan, A., A. Bartesaghi, and G. Sapiro. “Constrained regularization of digital terrain elevation data.” Ieee Geoscience and Remote Sensing Letters 3, no. 1 (January 1, 2006): 59–62. https://doi.org/10.1109/LGRS.2005.856702.
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  - Bartesaghi, A., and G. Sapiro. “Tracking of moving objects under severe and total occlusions.” Proceedings International Conference on Image Processing, Icip 1 (December 1, 2005): 301–4. https://doi.org/10.1109/ICIP.2005.1529747.
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  - Bartesaghi, Alberto, Guillermo Sapiro, and Sriram Subramaniam. “An energy-based three-dimensional segmentation approach for the quantitative interpretation of electron tomograms.” Ieee Transactions on Image Processing : A Publication of the Ieee Signal Processing Society 14, no. 9 (September 2005): 1314–23. https://doi.org/10.1109/tip.2005.852467.
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  - Bartesaghi, A., G. Sapiro, T. Malzbender, and D. Gelb. “Three-dimensional shape rendering from multiple images.” Graphical Models 67, no. 4 (July 1, 2005): 332–46. https://doi.org/10.1016/j.gmod.2005.02.002.
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  - Bartesaghi, A., G. Sapiro, S. Lee, J. Lefman, S. Wahl, J. Orenstein, and S. Subramaniam. “A new approach for 3D segmentation of cellular tomograms obtained using three-dimensional electron microscopy.” 2004 2nd Ieee International Symposium on Biomedical Imaging: Macro to Nano 1 (December 1, 2004): 5–8.
  - Bartesaghi, A., G. Sapiro, T. Malzbender, and D. Gelb. “Non-photorealistic rendering from multiple images.” Proceedings International Conference on Image Processing, Icip 4 (December 1, 2004): 2403–6. https://doi.org/10.1109/ICIP.2004.1421585.
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  - Bartesaghi, A., and G. Sapiro. “A system for the generation of curves on 3D brain images.” Human Brain Mapping 14, no. 1 (September 2001): 1–15. https://doi.org/10.1002/hbm.1037.
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  - Baronciani, D., G. Atti, F. Andiloro, A. Bartesaghi, L. Gagliardi, C. Passamonti, M. Petrone, et al. “Screening for developmental dysplasia of the hip: From theory to practice.” Pediatrics 99, no. 2 (February 1, 1997): E51–55.
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  - Baronciani, D., G. Atti, F. Andiloro, A. Bartesaghi, L. Gagliardi, C. Passamonti, and M. Petrone. “Screening for developmental dysplasia of the hip: from theory to practice. Collaborative Group DDH Project.” Pediatrics 99, no. 2 (February 1997): E5. https://doi.org/10.1542/peds.99.2.e5.
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  - Incerti, M., F. Guerreschi, A. Bartesaghi, R. Rigoni, and R. Bonfanti. “Treatment of the complex fractures of the ankle joint by Ilizarov's technique.” Minerva Ortopedica E Traumatologica 43, no. 3 (January 1, 1992): 167–71.
  - Incerti, M., and A. Bartesaghi. “Review of lateral capsulo-ligamentorhapphy operations carried out to prevent post-distortion instability of the tibiotarsal joint in sportsmen.” Minerva Ortopedica E Traumatologica 40, no. 4 (January 1, 1989): 219–24.
- Conference Papers
  - Bartesaghi, Alberto. “Streamlining Workflows for Structure Determination by Single Particle Cryo-EM.” In Biophysical Journal, 116:11a-11a. Elsevier BV, 2019. https://doi.org/10.1016/j.bpj.2018.11.100.
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  - Tran, Erin, Kira Podolsky, Alberto Bartesaghi, Oleg Kuybeda, Giovanna Grandinetti, Teddy John Wohlbold, Gene Tan, et al. “Cryo-EM Tomographic Analysis of a Universal Influenza Virus Vaccine Candidate.” In Biophysical Journal, 112:577a-577a. Elsevier BV, 2017. https://doi.org/10.1016/j.bpj.2016.11.3105.
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  - Borgnia, Mario J., Soojay Banerjee, Alberto Bartesaghi, Doreen Matthies, Prashant Rao, Alan Merk, Jason Pierson, Jacqueline L. Milne, and Sriram Subramaniam. “Using cryo-EM to Untangle the Conformational Landscape of a Small Allosterically-Regulated Complex.” In Biophysical Journal, 110:22a-22a. Elsevier BV, 2016. https://doi.org/10.1016/j.bpj.2015.11.179.
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  - Matthies, Doreen, Olivier Dalmas, Mario Borgnia, Pawel Dominik, Alan Merk, Prashant Rao, Bharat Reddy, et al. “Structures of the Mg2+ Channel Cora in the Open State by Cryo Electron Microscopy.” In Biophysical Journal, 110:291a-291a. Elsevier BV, 2016. https://doi.org/10.1016/j.bpj.2015.11.1574.
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  - Matthies, Doreen, Olivier Dalmas, Mario J. Borgnia, Pawel K. Dominik, Alan Merk, Prashant Rao, Bharat G. Reddy, et al. “Single-Particle Cryo-EM Studies of a 200-kDa Magnesium Ion Channel Reveal Large Structural Changes Upon Gating.” In Biophysical Journal, 110:10a-10a. Elsevier BV, 2016. https://doi.org/10.1016/j.bpj.2015.11.109.
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  - Borgnia, Mario J., Soojay Banerjee, Prashant Rao, Alberto Bartesaghi, Allan Merk, Jason Pierson, Sriram Subramaniam, and Jacqueline Milne. “Localization of Small Ligands in a Metabolic Protein Complex using Cryo-Electron Microscopy.” In Biophysical Journal, 108:514a-514a. Elsevier BV, 2015. https://doi.org/10.1016/j.bpj.2014.11.2818.
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  - Matthies, Doreen, Alberto Bartesaghi, Alan Merk, Soojay Banerjee, and Sriram Subramaniam. “Residue Specific Radiation Damage of Protein Structures using High-Resolution Cryo-Electron Microscopy.” In Biophysical Journal, 108:190a-190a. Elsevier BV, 2015. https://doi.org/10.1016/j.bpj.2014.11.1052.
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  - Meyerson, Joel R., Janesh Kumar, Sagar Chittori, Prashant Rao, Jason Pierson, Alberto Bartesaghi, Mark L. Mayer, and Sriram Subramaniam. “Structural Mechanism of Glutamate Receptor Activation and Desensitization.” In Biophysical Journal, 108:287a-287a. Elsevier BV, 2015. https://doi.org/10.1016/j.bpj.2014.11.1568.
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  - Bartesaghi, Alberto, Jason Pierson, Prashant Rao, Soojay Banerjee, Mario Borgnia, Lingbo Yu, Lesley Earl, Michael Alink, Jacqueline Milne, and Sriram Subramaniam. “Structure Determination of Small Macromolecular Complexes by Cryo-Electron Microscopy.” In Biophysical Journal, 106:601a-601a. Elsevier BV, 2014. https://doi.org/10.1016/j.bpj.2013.11.3329.
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  - Yoo, T. S., B. C. Lowekamp, O. Kuybeda, K. Narayan, G. A. Frank, A. Bartesaghi, M. Borgnia, S. Subramaniam, G. Sapiro, and M. J. Ackerman. “Accelerating discovery in 3D microanalysis: Leveraging open source software and deskside high performance computing.” In Microscopy and Microanalysis, 20:774–75, 2014. https://doi.org/10.1017/S1431927614005595.
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  - Bartesaghi, Alberto, Jason Pierson, David Schauder, Mario Borgnia, and Sriram Subramaniam. “Automated Workflows for Structure Determination by Single-Particle Cryo-EM at Sub-Nanometer Resolutions.” In Biophysical Journal, 104:352a-352a. Elsevier BV, 2013. https://doi.org/10.1016/j.bpj.2012.11.1955.
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  - Borgnia, Mario J., Alberto Bartesaghi, Erin Tran, Jacqueline L. S. Milne, and Sriram Subramaniam. “9 Å Structure of Trimeric HIV-1 Envelope Glycoprotein in an Activated State.” In Biophysical Journal, 104:350a-350a. Elsevier BV, 2013. https://doi.org/10.1016/j.bpj.2012.11.1946.
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  - Frank, Gabriel A., Oleg Kuybeda, Alberto Bartesaghi, Mario J. Borgnia, Guillermo Sapiro, and Sriram Subramaniam. “Computational Separation of Conformational Heterogeneity using Cryo-Electron Tomography and 3D Sub-Volume Averaging.” In Biophysical Journal, 104:350a-351a. Elsevier BV, 2013. https://doi.org/10.1016/j.bpj.2012.11.1947.
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  - Schauder, David M., Oleg Kuybeda, Jinjin Zhang, Katherine Klymko, Alberto Bartesaghi, Mario J. Borgnia, Mark L. Mayer, and Sriram Subramaniam. “Glutamate Receptor Desensitization Mediated by Changes in Quaternary Structure of the Ligand Binding Domain.” In Biophysical Journal, 104:352a-352a. Elsevier BV, 2013. https://doi.org/10.1016/j.bpj.2012.11.1953.
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  - Tran, Erin E. H., Oleg Kuybeda, Alberto Bartesaghi, Jacqueline L. S. Milne, and Sriram Subramaniam. “Binding of Neutralizing Antibodies Results in Distinct Quaternary Conformations of Trimeric HIV-1 Envelope Glycoproteins.” In Biophysical Journal, 104:352a-352a. Elsevier BV, 2013. https://doi.org/10.1016/j.bpj.2012.11.1952.
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  - Bartesaghi, Alberto, Pablo Sprechmann, Gregory Randall, Guillermo Sapiro, and Sriram Subramaniam. “A framework for classification and averaging of 3D tomographic volumes.” In Biophysical Journal, 509A-509A. BIOPHYSICAL SOCIETY, 2007.
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  - Bartesaghi, A., and M. Nadar. “Segmentation of anatomical structure from DT-MRI.” In 2006 3rd Ieee International Symposium on Biomedical Imaging: From Nano to Macro Proceedings, 2006:61–64, 2006.
  - Bartesaghi, A., and G. Sapiro. “Tracking of moving objects under severe and total occlusions.” In 2005 International Conference on Image Processing (Icip), Vols 1 5, 249–52. IEEE, 2005.
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  - Bartesaghi, A., A. Fernández, and A. Gómez. “Performance evaluation of an automatic fingerprint classification algorithm adapted to a Vucetich based classification system.” In Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), 2091 LNCS:259–65, 2001. https://doi.org/10.1007/3-540-45344-x_38.
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  - Guerreschi, F., M. Incerti, A. Bartesaghi, R. Rigoni, and R. Cattaneo. “Correction of monoplanar and biplanar axial deviations of lower limbs with Ilizarov method.” In Minerva Ortopedica E Traumatologica, 42:405–11, 1991.
  - Incerti, M., A. Villa, R. Rigoni, A. Bartesaghi, and F. Guerreschi. “Indications for G. A. Ilizarov's astragalarcalcaneal curvilinear osteotomy.” In Chirurgia Del Piede, 15:147–51, 1991.
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