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Digital pathology with Fourier ptychography.

Publication ,  Journal Article
Horstmeyer, R; Ou, X; Zheng, G; Willems, P; Yang, C
Published in: Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society
June 2015

Fourier ptychographic microscopy (FPM) is a recently introduced method of acquiring high-resolution, wide field of view (FOV) giga-pixel histology images. The FPM procedure first acquires a sequence of low-resolution images of a sample under variable-angle illumination. It then combines these images using a novel phase retrieval algorithm to improve the employed microscope's resolution beyond its conventional limit. Here, we first describe how FPM's resolution improvement can enhance wide FOV histology imaging. Second, we show that FPM also records a thin sample's optical phase, which can help pathologists digitally extract as much information as possible from a given histology slide.

Duke Scholars

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Published In

Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society

DOI

EISSN

1879-0771

ISSN

0895-6111

Publication Date

June 2015

Volume

42

Start / End Page

38 / 43

Related Subject Headings

  • Signal Processing, Computer-Assisted
  • Sensitivity and Specificity
  • Reproducibility of Results
  • Nuclear Medicine & Medical Imaging
  • Microscopy, Phase-Contrast
  • Lighting
  • Image Interpretation, Computer-Assisted
  • Image Enhancement
  • Histological Techniques
  • Fourier Analysis
 

Citation

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Horstmeyer, R., Ou, X., Zheng, G., Willems, P., & Yang, C. (2015). Digital pathology with Fourier ptychography. Computerized Medical Imaging and Graphics : The Official Journal of the Computerized Medical Imaging Society, 42, 38–43. https://doi.org/10.1016/j.compmedimag.2014.11.005
Horstmeyer, Roarke, Xiaoze Ou, Guoan Zheng, Phil Willems, and Changhuei Yang. “Digital pathology with Fourier ptychography.Computerized Medical Imaging and Graphics : The Official Journal of the Computerized Medical Imaging Society 42 (June 2015): 38–43. https://doi.org/10.1016/j.compmedimag.2014.11.005.
Horstmeyer R, Ou X, Zheng G, Willems P, Yang C. Digital pathology with Fourier ptychography. Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society. 2015 Jun;42:38–43.
Horstmeyer, Roarke, et al. “Digital pathology with Fourier ptychography.Computerized Medical Imaging and Graphics : The Official Journal of the Computerized Medical Imaging Society, vol. 42, June 2015, pp. 38–43. Epmc, doi:10.1016/j.compmedimag.2014.11.005.
Horstmeyer R, Ou X, Zheng G, Willems P, Yang C. Digital pathology with Fourier ptychography. Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society. 2015 Jun;42:38–43.
Journal cover image

Published In

Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society

DOI

EISSN

1879-0771

ISSN

0895-6111

Publication Date

June 2015

Volume

42

Start / End Page

38 / 43

Related Subject Headings

  • Signal Processing, Computer-Assisted
  • Sensitivity and Specificity
  • Reproducibility of Results
  • Nuclear Medicine & Medical Imaging
  • Microscopy, Phase-Contrast
  • Lighting
  • Image Interpretation, Computer-Assisted
  • Image Enhancement
  • Histological Techniques
  • Fourier Analysis