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Biology of adeno-associated viral vectors in the central nervous system.

Publication ,  Journal Article
Murlidharan, G; Samulski, RJ; Asokan, A
Published in: Front Mol Neurosci
2014

Gene therapy is a promising approach for treating a spectrum of neurological and neurodegenerative disorders by delivering corrective genes to the central nervous system (CNS). In particular, adeno-associated viruses (AAVs) have emerged as promising tools for clinical gene transfer in a broad range of genetic disorders with neurological manifestations. In the current review, we have attempted to bridge our understanding of the biology of different AAV strains with their transduction profiles, cellular tropisms, and transport mechanisms within the CNS. Continued efforts to dissect AAV-host interactions within the brain are likely to aid in the development of improved vectors for CNS-directed gene transfer applications in the clinic.

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Published In

Front Mol Neurosci

DOI

ISSN

1662-5099

Publication Date

2014

Volume

7

Start / End Page

76

Location

Switzerland

Related Subject Headings

  • 5202 Biological psychology
  • 3209 Neurosciences
  • 3101 Biochemistry and cell biology
  • 1109 Neurosciences
  • 1103 Clinical Sciences
 

Citation

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ICMJE
MLA
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Murlidharan, G., Samulski, R. J., & Asokan, A. (2014). Biology of adeno-associated viral vectors in the central nervous system. Front Mol Neurosci, 7, 76. https://doi.org/10.3389/fnmol.2014.00076
Murlidharan, Giridhar, Richard J. Samulski, and Aravind Asokan. “Biology of adeno-associated viral vectors in the central nervous system.Front Mol Neurosci 7 (2014): 76. https://doi.org/10.3389/fnmol.2014.00076.
Murlidharan G, Samulski RJ, Asokan A. Biology of adeno-associated viral vectors in the central nervous system. Front Mol Neurosci. 2014;7:76.
Murlidharan, Giridhar, et al. “Biology of adeno-associated viral vectors in the central nervous system.Front Mol Neurosci, vol. 7, 2014, p. 76. Pubmed, doi:10.3389/fnmol.2014.00076.
Murlidharan G, Samulski RJ, Asokan A. Biology of adeno-associated viral vectors in the central nervous system. Front Mol Neurosci. 2014;7:76.

Published In

Front Mol Neurosci

DOI

ISSN

1662-5099

Publication Date

2014

Volume

7

Start / End Page

76

Location

Switzerland

Related Subject Headings

  • 5202 Biological psychology
  • 3209 Neurosciences
  • 3101 Biochemistry and cell biology
  • 1109 Neurosciences
  • 1103 Clinical Sciences