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Urologic chronic pelvic pain syndrome: insights from the MAPP Research Network.

Publication ,  Journal Article
Clemens, JQ; Mullins, C; Ackerman, AL; Bavendam, T; van Bokhoven, A; Ellingson, BM; Harte, SE; Kutch, JJ; Lai, HH; Martucci, KT; Moldwin, R ...
Published in: Nat Rev Urol
March 2019

Urologic chronic pelvic pain syndrome (UCPPS), which encompasses interstitial cystitis/bladder pain syndrome and chronic prostatitis/chronic pelvic pain syndrome, is characterized by chronic pain in the pelvic region or genitalia that is often accompanied by urinary frequency and urgency. Despite considerable research, no definite aetiological risk factors or effective treatments have been identified. The Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network uses a novel integrated strategy to characterize UCPPS as a systemic disorder that potentially involves multiple aetiologies. The first phase, MAPP I, included >1,000 participants who completed an intensive baseline assessment followed by a 12-month observational follow-up period. MAPP I studies showed that UCPPS pain and urinary symptoms co-vary, with only moderate correlation, and should be evaluated separately and that symptom flares are common and can differ considerably in intensity, duration and influence on quality of life. Longitudinal clinical changes in UCPPS correlated with structural and functional brain changes, and many patients experienced global multisensory hypersensitivity. Additionally, UCPPS symptom profiles were distinguishable by biological correlates, such as immune factors. These findings indicate that patients with UCPPS have objective phenotypic abnormalities and distinct biological characteristics, providing a new foundation for the study and clinical management of UCPPS.

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Published In

Nat Rev Urol

DOI

EISSN

1759-4820

Publication Date

March 2019

Volume

16

Issue

3

Start / End Page

187 / 200

Location

England

Related Subject Headings

  • Urology & Nephrology
  • Syndrome
  • Prostatitis
  • Pelvic Pain
  • Male
  • Interdisciplinary Research
  • Humans
  • Cystitis, Interstitial
  • Chronic Pain
  • Biomedical Research
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Clemens, J. Q., Mullins, C., Ackerman, A. L., Bavendam, T., van Bokhoven, A., Ellingson, B. M., … MAPP Research Network Study Group, . (2019). Urologic chronic pelvic pain syndrome: insights from the MAPP Research Network. Nat Rev Urol, 16(3), 187–200. https://doi.org/10.1038/s41585-018-0135-5
Clemens, J Quentin, Chris Mullins, A Lenore Ackerman, Tamara Bavendam, Adrie van Bokhoven, Benjamin M. Ellingson, Steven E. Harte, et al. “Urologic chronic pelvic pain syndrome: insights from the MAPP Research Network.Nat Rev Urol 16, no. 3 (March 2019): 187–200. https://doi.org/10.1038/s41585-018-0135-5.
Clemens JQ, Mullins C, Ackerman AL, Bavendam T, van Bokhoven A, Ellingson BM, et al. Urologic chronic pelvic pain syndrome: insights from the MAPP Research Network. Nat Rev Urol. 2019 Mar;16(3):187–200.
Clemens, J. Quentin, et al. “Urologic chronic pelvic pain syndrome: insights from the MAPP Research Network.Nat Rev Urol, vol. 16, no. 3, Mar. 2019, pp. 187–200. Pubmed, doi:10.1038/s41585-018-0135-5.
Clemens JQ, Mullins C, Ackerman AL, Bavendam T, van Bokhoven A, Ellingson BM, Harte SE, Kutch JJ, Lai HH, Martucci KT, Moldwin R, Naliboff BD, Pontari MA, Sutcliffe S, Landis JR, MAPP Research Network Study Group. Urologic chronic pelvic pain syndrome: insights from the MAPP Research Network. Nat Rev Urol. 2019 Mar;16(3):187–200.

Published In

Nat Rev Urol

DOI

EISSN

1759-4820

Publication Date

March 2019

Volume

16

Issue

3

Start / End Page

187 / 200

Location

England

Related Subject Headings

  • Urology & Nephrology
  • Syndrome
  • Prostatitis
  • Pelvic Pain
  • Male
  • Interdisciplinary Research
  • Humans
  • Cystitis, Interstitial
  • Chronic Pain
  • Biomedical Research