Overview
Katherine Martucci Ph.D. is a neuroscientist who specializes in human clinical research of chronic pain, reward and motivation behaviors, sensory and acute pain perception, and opioid use and addiction. Dr. Martucci serves as Director of the Human Affect and Pain Neuroscience Lab which uses a combination of neuroimaging techniques, including functional magnetic resonance imaging (fMRI) of the brain and cervical spinal cord, as well as sensory, behavioral and psychological tests to study acute and chronic pain in humans.
As part of the Center for Translational Pain Medicine (CTPM), Dr. Martucci’s lab is part of Duke University’s Department of Anesthesiology, conducting research in collaboration with the Brain Imaging and Analysis Center (BIAC) and Duke Institute for Brain Sciences (DIBS).
Dr. Martucci earned her Ph.D. in Neurobiology and Anatomy at Wake Forest School of Medicine and continued her training in clinical research with a postdoctoral fellowship at Stanford University. While at Stanford, Dr. Martucci obtained a prestigious NIH K99 “Pathway to Independence Award”. Since joining Duke University in 2018, Dr. Martucci has acquired funding via multiple NIH grants to continue her line of neuroimaging clinical research of the central nervous system in chronic pain.
Current Appointments & Affiliations
Recent Publications
Reply to the Letter to the Editor.
Journal Article Arthritis Rheumatol · December 26, 2025 Full text Link to item CitePreclinical perspectives on disorders of the temporomandibular joint: Tracing the past, navigating the present, and shaping the future.
Journal Article J Pain · November 2025 Temporomandibular disorders (TMDs) are complex conditions characterized by orofacial pain and dysfunction, affecting a significant portion of the population. TMDs may involve joint and/or muscle pain, dysfunction (e.g., noise, limited or altered jaw moveme ... Full text Open Access Link to item CitePain in systemic lupus erythematosus: emerging insights and paradigms.
Journal Article Nat Rev Rheumatol · October 2025 Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by protean clinical manifestations that are associated with immune system dysregulation. Of these manifestations, pain and pain-related symptoms such as fatigue, mood disturba ... Full text Link to item CiteRecent Grants
Neural correlates and behavioral impact of withdrawal-induced hyperalgesia among people who smoke with and without chronic pain
ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2025 - 2030Neurobiological Effects of Long-Term Opioid Therapy in the Brain and Spinal Cord
ResearchPrincipal Investigator · Awarded by National Institute on Drug Abuse · 2022 - 2027Accelerated rTMS of MPFC Circuits: A Pilot Mechanistic Clinical Trial in FMS
ResearchPrincipal Investigator · Awarded by American Fibromyalgia Syndrome Association · 2025 - 2026View All Grants