Katherine Martucci | Scholars@Duke

Katherine Martucci
Assistant Professor in Anesthesiology

Katherine Martucci Ph.D. is a neuroscientist who specializes in human clinical research of chronic pain, reward and motivation behaviors, sensory and acute pain perception, and opioid use and addiction. Dr. Martucci serves as Director of the Human Affect and Pain Neuroscience Lab which uses a combination of neuroimaging techniques, including functional magnetic resonance imaging (fMRI) of the brain and cervical spinal cord, as well as sensory, behavioral and psychological tests to study acute and chronic pain in humans.

As part of the Center for Translational Pain Medicine (CTPM) at Duke, Dr. Martucci’s lab is in the Department of Anesthesiology and conducts research in collaboration with the Brain Imaging and Analysis Center (BIAC) and Duke Institute for Brain Sciences (DIBS).

Dr. Martucci earned her Ph.D. in Neurobiology and Anatomy at Wake Forest School of Medicine and continued her training in clinical research with a postdoctoral fellowship at Stanford University. While at Stanford Dr. Martucci obtained a prestigious NIH K99 “Pathway to Independence Award” and launched her research program in human neuroscience of pain, reward, opioids, and addiction. At the start of her scientific career at Duke, Dr. Martucci obtained a NIH R00 “Transition to Independence Award” to conduct the first longitudinal neuroimaging clinical research study of how opioid medications affect the central nervous system in individuals with fibromyalgia. Dr. Martucci is passionate about providing new scientific knowledge related to chronic pain and opioid use and how these factors together influence central nervous system function and symptoms in individuals with chronic pain.

Current Appointments & Affiliations

Assistant Professor in Anesthesiology, Anesthesiology, Clinical Science Departments 2021
Faculty Network Member of the Duke Institute for Brain Sciences, Duke Institute for Brain Sciences, University Institutes and Centers 2018

Contact Information

3 Genome Ct, Rm. #6134, Durham, NC 27710
DUMC 3094, Durham, NC 27710
katherine.martucci@duke.edu (919) 613-8023
@DrKatieMartucci
Dr. Katherine Martucci's LinkedIn
Duke Center for Translational Pain Medicine
Lab Website

Background
Education, Training, & Certifications
- Post-Doctoral Training, Stanford University 2012 - 2018
- Ph.D., Wake Forest University School Of Medicine 2011
- B.S., University of Connecticut 2005
Previous Appointments & Affiliations
- Assistant Professor in Anesthesiology, Anesthesiology, Clinical Science Departments 2018 - 2020
Leadership & Clinical Positions at Duke
- Director, Human Affect and Pain Neuroscience Laboratory
  Translational Research Scholar, ABLE Program 2020
Recognition
Awards & Honors
Expertise
Subject Headings
Research
Selected Grants
- Neurobiological Effects of Long-Term Opioid Therapy in the Brain and Spinal Cord awarded by National Institutes of Health 2022 - 2027
- Integrated Training in Anesthesiology Research awarded by National Institutes of Health 1996 - 2026
- Duke Pain Early-phase Research Clinical Center (PERC) awarded by National Institutes of Health 2019 - 2024
- A High-Performance 3T MRI for Brain Imaging awarded by National Institutes of Health 2021 - 2022
- The Impact of Opioids on Chronic Pain: Clinical Research and Career Training in Spinal Cord fMRI and Brain Reward Systems awarded by National Institutes of Health 2018 - 2021
Fellowships, Supported Research, & Other Grants
- NIH Pathway to Independence Award (K99/R00) awarded by NIH NIDA 2015 - 2018
- NIH Loan Repayment Program in Clinical Research awarded by NIH LRP 2014 - 2016
- NIH Institutional Postdoctoral Anesthesia Training Program in Biomedical Research (T32) awarded by NIH NIGMS 2013 - 2015
- NIH Individual Predoctoral Ruth L. Kirschstein National Research Service Award (F31) awarded by NIH NIDA 2010 - 2012
- NIH Institutional Predoctoral Neurobiology and Anatomy Sensory Training Grant (T31) awarded by NIH NINDS 2007 - 2009
External Relationships
- NIH Office of Scientific Review
- Tesla
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Park, Su Hyoun, Anne K. Baker, Vinit Krishna, Sean C. Mackey, and Katherine T. Martucci. “Altered resting-state functional connectivity within corticostriatal and subcortical-striatal circuits in chronic pain.” Sci Rep 12, no. 1 (July 25, 2022): 12683. https://doi.org/10.1038/s41598-022-16835-7.
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  - Berger, Miles, Jeffrey N. Browndyke, Mary Cooter Wright, Chloe Nobuhara, Melody Reese, Leah Acker, W Michael Bullock, et al. “Postoperative changes in cognition and cerebrospinal fluid neurodegenerative disease biomarkers.” Ann Clin Transl Neurol 9, no. 2 (February 2022): 155–70. https://doi.org/10.1002/acn3.51499.
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  - Baker, Anne K., Lauren C. Ericksen, Vincent Koppelmans, Brian J. Mickey, Katherine T. Martucci, Jon-Kar Zubieta, and Tiffany M. Love. “Altered Reward Processing and Sex Differences in Chronic Pain.” Front Neurosci 16 (2022): 889849. https://doi.org/10.3389/fnins.2022.889849.
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  - Deng, Eden Z., Daniel P. Weikel, and Katherine T. Martucci. “Evaluation by Survival Analysis of Cold Pain Tolerance in Patients with Fibromyalgia and Opioid Use.” J Pain Res 15 (2022): 2783–99. https://doi.org/10.2147/JPR.S368805.
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  - Browndyke, Jeffrey N., Mary C. Wright, Rosa Yang, Ayesha Syed, John Park, Ashley Hall, Katherine Martucci, et al. “Perioperative neurocognitive and functional neuroimaging trajectories in older APOE4 carriers compared with non-carriers: secondary analysis of a prospective cohort study.” Br J Anaesth 127, no. 6 (December 2021): 917–28. https://doi.org/10.1016/j.bja.2021.08.012.
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  - Karshikoff, Bianka, Katherine T. Martucci, and Sean Mackey. “Relationship Between Blood Cytokine Levels, Psychological Comorbidity, and Widespreadness of Pain in Chronic Pelvic Pain.” Front Psychiatry 12 (2021): 651083. https://doi.org/10.3389/fpsyt.2021.651083.
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  - Martucci, Katherine T., Kenneth A. Weber, and Sean C. Mackey. “Spinal Cord Resting State Activity in Individuals With Fibromyalgia Who Take Opioids.” Front Neurol 12 (2021): 694271. https://doi.org/10.3389/fneur.2021.694271.
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  - Martucci, Katherine T., Kelly H. MacNiven, Nicholas Borg, Brian Knutson, and Sean C. Mackey. “Apparent Effects of Opioid Use on Neural Responses to Reward in Chronic Pain.” Sci Rep 9, no. 1 (July 3, 2019): 9633. https://doi.org/10.1038/s41598-019-45961-y.
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  - Mackey, Sean, Henry T. Greely, and Katherine T. Martucci. “Neuroimaging-based pain biomarkers: definitions, clinical and research applications, and evaluation frameworks to achieve personalized pain medicine.” Pain Rep 4, no. 4 (July 2019): e762. https://doi.org/10.1097/PR9.0000000000000762.
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  - Martucci, Katherine T., Kenneth A. Weber, and Sean C. Mackey. “Altered Cervical Spinal Cord Resting-State Activity in Fibromyalgia.” Arthritis Rheumatol 71, no. 3 (March 2019): 441–50. https://doi.org/10.1002/art.40746.
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  - Clemens, J Quentin, Chris Mullins, A Lenore Ackerman, Tamara Bavendam, Adrie van Bokhoven, Benjamin M. Ellingson, Steven E. Harte, et al. “Urologic chronic pelvic pain syndrome: insights from the MAPP Research Network.” Nat Rev Urol 16, no. 3 (March 2019): 187–200. https://doi.org/10.1038/s41585-018-0135-5.
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  - Martucci, Katherine T., Nicholas Borg, Kelly H. MacNiven, Brian Knutson, and Sean C. Mackey. “Altered prefrontal correlates of monetary anticipation and outcome in chronic pain.” Pain 159, no. 8 (August 2018): 1494–1507. https://doi.org/10.1097/j.pain.0000000000001232.
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  - Martucci, Katherine T., and Sean C. Mackey. “Neuroimaging of Pain: Human Evidence and Clinical Relevance of Central Nervous System Processes and Modulation.” Anesthesiology 128, no. 6 (June 2018): 1241–54. https://doi.org/10.1097/ALN.0000000000002137.
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  - Kutch, Jason J., Eric Ichesco, Johnson P. Hampson, Jennifer S. Labus, Melissa A. Farmer, Katherine T. Martucci, Timothy J. Ness, et al. “Brain signature and functional impact of centralized pain: a multidisciplinary approach to the study of chronic pelvic pain (MAPP) network study.” Pain 158, no. 10 (October 2017): 1979–91. https://doi.org/10.1097/j.pain.0000000000001001.
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  - Kutch, Jason J., Jennifer S. Labus, Richard E. Harris, Katherine T. Martucci, Melissa A. Farmer, Sonja Fenske, Connor Fling, et al. “Resting-state functional connectivity predicts longitudinal pain symptom change in urologic chronic pelvic pain syndrome: a MAPP network study.” Pain 158, no. 6 (June 2017): 1069–82. https://doi.org/10.1097/j.pain.0000000000000886.
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  - Martucci, Katherine T. “Disentangling mood and pain: a commentary on 2 manuscripts.” Pain 158, no. 1 (January 2017): 4–5. https://doi.org/10.1097/j.pain.0000000000000746.
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  - Huang, Lejian, Jason J. Kutch, Benjamin M. Ellingson, Katherine T. Martucci, Richard E. Harris, Daniel J. Clauw, Sean Mackey, et al. “Brain white matter changes associated with urological chronic pelvic pain syndrome: multisite neuroimaging from a MAPP case-control study.” Pain 157, no. 12 (December 2016): 2782–91. https://doi.org/10.1097/j.pain.0000000000000703.
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  - Martucci, Katherine T., and Sean C. Mackey. “Imaging Pain.” Anesthesiol Clin 34, no. 2 (June 2016): 255–69. https://doi.org/10.1016/j.anclin.2016.01.001.
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  - Martucci, Katherine T., William R. Shirer, Epifanio Bagarinao, Kevin A. Johnson, Melissa A. Farmer, Jennifer S. Labus, A Vania Apkarian, et al. “The posterior medial cortex in urologic chronic pelvic pain syndrome: detachment from default mode network-a resting-state study from the MAPP Research Network.” Pain 156, no. 9 (September 2015): 1755–64. https://doi.org/10.1097/j.pain.0000000000000238.
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  - Farmer, Melissa A., Lejian Huang, Katherine Martucci, Claire C. Yang, Kenneth R. Maravilla, Richard E. Harris, Daniel J. Clauw, et al. “Brain White Matter Abnormalities in Female Interstitial Cystitis/Bladder Pain Syndrome: A MAPP Network Neuroimaging Study.” J Urol 194, no. 1 (July 2015): 118–26. https://doi.org/10.1016/j.juro.2015.02.082.
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  - Kairys, Anson E., Tobias Schmidt-Wilcke, Tudor Puiu, Eric Ichesco, Jennifer S. Labus, Katherine Martucci, Melissa A. Farmer, et al. “Increased brain gray matter in the primary somatosensory cortex is associated with increased pain and mood disturbance in patients with interstitial cystitis/painful bladder syndrome.” J Urol 193, no. 1 (January 2015): 131–37. https://doi.org/10.1016/j.juro.2014.08.042.
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  - Bagarinao, Epifanio, Kevin A. Johnson, Katherine T. Martucci, Eric Ichesco, Melissa A. Farmer, Jennifer Labus, Timothy J. Ness, et al. “Preliminary structural MRI based brain classification of chronic pelvic pain: A MAPP network study.” Pain 155, no. 12 (December 2014): 2502–9. https://doi.org/10.1016/j.pain.2014.09.002.
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  - Nahman-Averbuch, Hadas, Katherine T. Martucci, Yelena Granovsky, Irit Weissman-Fogel, David Yarnitsky, and Robert C. Coghill. “Distinct brain mechanisms support spatial vs temporal filtering of nociceptive information.” Pain 155, no. 12 (December 2014): 2491–2501. https://doi.org/10.1016/j.pain.2014.07.008.
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  - Martucci, Katherine T., Pamela Ng, and Sean Mackey. “Neuroimaging chronic pain: what have we learned and where are we going?” Future Neurol 9, no. 6 (November 2014): 615–26. https://doi.org/10.2217/FNL.14.57.
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  - Kilpatrick, Lisa A., Jason J. Kutch, Kirsten Tillisch, Bruce D. Naliboff, Jennifer S. Labus, Zhiguo Jiang, Melissa A. Farmer, et al. “Alterations in resting state oscillations and connectivity in sensory and motor networks in women with interstitial cystitis/painful bladder syndrome.” J Urol 192, no. 3 (September 2014): 947–55. https://doi.org/10.1016/j.juro.2014.03.093.
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  - Zeidan, Fadel, Katherine T. Martucci, Robert A. Kraft, John G. McHaffie, and Robert C. Coghill. “Neural correlates of mindfulness meditation-related anxiety relief.” Soc Cogn Affect Neurosci 9, no. 6 (June 2014): 751–59. https://doi.org/10.1093/scan/nst041.
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  - Emerson, Nichole M., Fadel Zeidan, Oleg V. Lobanov, Morten S. Hadsel, Katherine T. Martucci, Alexandre S. Quevedo, Christopher J. Starr, et al. “Pain sensitivity is inversely related to regional grey matter density in the brain.” Pain 155, no. 3 (March 2014): 566–73. https://doi.org/10.1016/j.pain.2013.12.004.
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  - Martucci, K. T., J. C. Eisenach, C. Tong, and R. C. Coghill. “Opioid-independent mechanisms supporting offset analgesia and temporal sharpening of nociceptive information.” Pain 153, no. 6 (June 2012): 1232–43. https://doi.org/10.1016/j.pain.2012.02.035.
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  - Martucci, Katherine T., Marc D. Yelle, and Robert C. Coghill. “Differential effects of experimental central sensitization on the time-course and magnitude of offset analgesia.” Pain 153, no. 2 (February 2012): 463–72. https://doi.org/10.1016/j.pain.2011.11.010.
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  - Zeidan, Fadel, Katherine T. Martucci, Robert A. Kraft, Nakia S. Gordon, John G. McHaffie, and Robert C. Coghill. “Brain mechanisms supporting the modulation of pain by mindfulness meditation.” J Neurosci 31, no. 14 (April 6, 2011): 5540–48. https://doi.org/10.1523/JNEUROSCI.5791-10.2011.
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  - Martucci, Katherine T., and Robert C. Coghill. “Regional anesthesia: functional implications beyond the anesthetized nerve.” Anesthesiology 114, no. 1 (January 2011): 21–23. https://doi.org/10.1097/ALN.0b013e3182016521.
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- Conference Papers
  - Baker, Anne, Meghna Nanda, Su Hyoun Park, and Katherine T. Martucci. “Variable Voxel-based Morphometry Observations of Gray Matter Differences in Fibromyalgia: Individual Differences or Methodological Inconsistency?” In Journal of Pain, 23:44–44, 2022.
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  - Park, Su Hyoun, Anne K. Baker, Vinit Krishna, Sean C. Mackey, and Katherine T. Martucci. “Evidence of Intact Corticostriatal and Altered Subcortical-striatal Resting-state Functional Connectivity in Chronic Pain.” In Journal of Pain, 23:44–44, 2022.
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  - Weber, Kenneth A., Christine S. Law, Yoni K. Asher, Katherine T. Martucci, Gadi Gilam, Bennett Lewis, Sahana Narayan, Trevor Hastie, Tor D. Wager, and Sean Mackey. “Resting State Functional Connectivity Machine Learning Classification of Chronic Back Pain.” In Annals of Neurology, 86:S266–S266. WILEY, 2019.
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  - Jarrahi, Behnaz, Katherine T. Martucci, Aneesha S. Nilakantan, and Sean Mackey. “Cold Water Pressor Test Differentially Modulates Functional Network Connectivity in Fibromyalgia Patients Compared with Healthy Controls.” In Annu Int Conf Ieee Eng Med Biol Soc, 2018:578–82, 2018. https://doi.org/10.1109/EMBC.2018.8512350.
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  - Jarrahi, Behnaz, Katherine T. Martucci, Aneesha S. Nilakantan, and Sean Mackey. “Investigating the BOLD spectral power of the intrinsic connectivity networks in fibromyalgia patients: A resting-state fMRI study.” In Annu Int Conf Ieee Eng Med Biol Soc, 2017:497–500, 2017. https://doi.org/10.1109/EMBC.2017.8036870.
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- Preprints
  - Deng, Eden Z., Daniel P. Weikel, and Katherine T. Martucci. “Evaluation of cold pain tolerance in patients with fibromyalgia and opioid use by survival analysis.” Cold Spring Harbor Laboratory, March 31, 2022. https://doi.org/10.1101/2022.03.26.22272966.
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  - Baker, Anne K., Meghna Nanda, Su Hyoun Park, and Katherine T. Martucci. “Attempt to replicate voxel-based morphometry analysis in fibromyalgia: Detection of below threshold differences framed by contributions of variable clinical presentation to low reproducibility.” Cold Spring Harbor Laboratory, March 8, 2022. https://doi.org/10.1101/2022.03.04.22271900.
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Teaching & Mentoring
Advising & Mentoring
- Research Mentorship
  
  Research Assistants / Research Coordinators
  2012-2014 Aneesha Nilakantan as a research coordinator, now Neuroscience PhD student, Northwestern University
  2013 - 2015 Amy Sentis as a research coordinator, now MD/PhD candidate at the University of Pittsburgh
  2014 - 2015 Lauren Foster as a research coordinator, now in Stanford Cancer Clinical Trials Office
  2016 Christina Cojocaru as a research coordinator, now a Medical Student at Midwestern University
  
  Undergraduate Student Research Assistants
  2012 Safwan Siddiqui as a sophomore Stanford undergraduate, now at Shockwave Medical
  2012 Emily Marx as a junior Stanford undergraduate, now Software Test Engineer at Illumina
  2014 - 2016 Marisa Borja as a sophomore - junior Stanford undergraduate, now at Biosense Webster
  2016 Erin Perrine as senior Stanford undergraduate, now intern at Google
  2017 Elizabeth Cha as a sophomore University of Rochester undergraduate
  2017 Grace Kim as a freshman Stanford undergraduate
  2017 Andrew Bassilakis as a junior Stanford undergraduate
  2018 Leah Tolby as a freshman Stanford undergraduate
  2019- Meghna Nanda, Duke undergraduate research assistant
  2019-Vinny Krishna, Duke undergraduate research assistant
  2019- Eden Deng, Duke undergraduate research assistant
Available to mentor:
- Post-Doc
- Undergraduate
Scholarly, Clinical, & Service Activities
Presentations & Appearances
Outreach & Engaged Scholarship
Service to the Profession
Service to Duke
- Department of Anesthesiology. ACES Clinical Research Candidate Review Committee. 2021 2021
- Department of Anesthesiology. Grand Rounds Steering Committee. 2021 2021

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Education, Training, & Certifications

Previous Appointments & Affiliations

Leadership & Clinical Positions at Duke

Awards & Honors

Subject Headings

Selected Grants

Fellowships, Supported Research, & Other Grants

External Relationships

Selected Publications

Academic Articles

Conference Papers

Preprints

Advising & Mentoring

Available to mentor:

Presentations & Appearances

Outreach & Engaged Scholarship

Service to the Profession

Service to Duke