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Impaired capacity to restore proteostasis in the aged brain after ischemia: Implications for translational brain ischemia research.

Publication ,  Journal Article
Wang, Z; Yang, W
Published in: Neurochem Int
July 2019

Brain ischemia induced by cardiac arrest or ischemic stroke is a severe form of metabolic stress that substantially disrupts cellular homeostasis, especially protein homeostasis (proteostasis). As proteostasis is fundamental for cellular and organismal health, cells have developed a complex network to restore proteostasis impaired by stress. Many components of this network - including ubiquitination, small ubiquitin-like modifier (SUMO) conjugation, autophagy, and the unfolded protein response (UPR) - are activated in the post-ischemic brain, and play a crucial role in cell survival and recovery of neurologic function. Importantly, recent studies have shown that ischemia-induced activation of these proteostasis-related pathways in the aged brain is impaired, indicating an aging-related decline in the self-healing capacity of the brain. This impaired capacity is a significant factor for consideration in the field of brain ischemia because the vast majority of cardiac arrest and stroke patients are elderly. In this review, we focus on the effects of aging on these critical proteostasis-related pathways in the brain, and discuss their implications in translational brain ischemia research.

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Published In

Neurochem Int

DOI

EISSN

1872-9754

Publication Date

July 2019

Volume

127

Start / End Page

87 / 93

Location

England

Related Subject Headings

  • Stroke
  • Proteostasis
  • Neurology & Neurosurgery
  • Humans
  • Homeostasis
  • Brain Ischemia
  • Brain
  • Animals
  • Aging
  • 3209 Neurosciences
 

Citation

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Wang, Z., & Yang, W. (2019). Impaired capacity to restore proteostasis in the aged brain after ischemia: Implications for translational brain ischemia research. Neurochem Int, 127, 87–93. https://doi.org/10.1016/j.neuint.2018.12.018
Wang, Zhuoran, and Wei Yang. “Impaired capacity to restore proteostasis in the aged brain after ischemia: Implications for translational brain ischemia research.Neurochem Int 127 (July 2019): 87–93. https://doi.org/10.1016/j.neuint.2018.12.018.
Wang, Zhuoran, and Wei Yang. “Impaired capacity to restore proteostasis in the aged brain after ischemia: Implications for translational brain ischemia research.Neurochem Int, vol. 127, July 2019, pp. 87–93. Pubmed, doi:10.1016/j.neuint.2018.12.018.
Journal cover image

Published In

Neurochem Int

DOI

EISSN

1872-9754

Publication Date

July 2019

Volume

127

Start / End Page

87 / 93

Location

England

Related Subject Headings

  • Stroke
  • Proteostasis
  • Neurology & Neurosurgery
  • Humans
  • Homeostasis
  • Brain Ischemia
  • Brain
  • Animals
  • Aging
  • 3209 Neurosciences