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Multivascular networks and functional intravascular topologies within biocompatible hydrogels.

Publication ,  Journal Article
Grigoryan, B; Paulsen, SJ; Corbett, DC; Sazer, DW; Fortin, CL; Zaita, AJ; Greenfield, PT; Calafat, NJ; Gounley, JP; Ta, AH; Johansson, F ...
Published in: Science (New York, N.Y.)
May 2019

Solid organs transport fluids through distinct vascular networks that are biophysically and biochemically entangled, creating complex three-dimensional (3D) transport regimes that have remained difficult to produce and study. We establish intravascular and multivascular design freedoms with photopolymerizable hydrogels by using food dye additives as biocompatible yet potent photoabsorbers for projection stereolithography. We demonstrate monolithic transparent hydrogels, produced in minutes, comprising efficient intravascular 3D fluid mixers and functional bicuspid valves. We further elaborate entangled vascular networks from space-filling mathematical topologies and explore the oxygenation and flow of human red blood cells during tidal ventilation and distension of a proximate airway. In addition, we deploy structured biodegradable hydrogel carriers in a rodent model of chronic liver injury to highlight the potential translational utility of this materials innovation.

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Published In

Science (New York, N.Y.)

DOI

EISSN

1095-9203

ISSN

0036-8075

Publication Date

May 2019

Volume

364

Issue

6439

Start / End Page

458 / 464

Related Subject Headings

  • Stereolithography
  • Polymerization
  • Mice, Nude
  • Mice
  • Lung Injury
  • Liver
  • Light
  • Hydrogels
  • Humans
  • General Science & Technology
 

Citation

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Grigoryan, B., Paulsen, S. J., Corbett, D. C., Sazer, D. W., Fortin, C. L., Zaita, A. J., … Miller, J. S. (2019). Multivascular networks and functional intravascular topologies within biocompatible hydrogels. Science (New York, N.Y.), 364(6439), 458–464. https://doi.org/10.1126/science.aav9750
Grigoryan, Bagrat, Samantha J. Paulsen, Daniel C. Corbett, Daniel W. Sazer, Chelsea L. Fortin, Alexander J. Zaita, Paul T. Greenfield, et al. “Multivascular networks and functional intravascular topologies within biocompatible hydrogels.Science (New York, N.Y.) 364, no. 6439 (May 2019): 458–64. https://doi.org/10.1126/science.aav9750.
Grigoryan B, Paulsen SJ, Corbett DC, Sazer DW, Fortin CL, Zaita AJ, et al. Multivascular networks and functional intravascular topologies within biocompatible hydrogels. Science (New York, NY). 2019 May;364(6439):458–64.
Grigoryan, Bagrat, et al. “Multivascular networks and functional intravascular topologies within biocompatible hydrogels.Science (New York, N.Y.), vol. 364, no. 6439, May 2019, pp. 458–64. Epmc, doi:10.1126/science.aav9750.
Grigoryan B, Paulsen SJ, Corbett DC, Sazer DW, Fortin CL, Zaita AJ, Greenfield PT, Calafat NJ, Gounley JP, Ta AH, Johansson F, Randles A, Rosenkrantz JE, Louis-Rosenberg JD, Galie PA, Stevens KR, Miller JS. Multivascular networks and functional intravascular topologies within biocompatible hydrogels. Science (New York, NY). 2019 May;364(6439):458–464.
Journal cover image

Published In

Science (New York, N.Y.)

DOI

EISSN

1095-9203

ISSN

0036-8075

Publication Date

May 2019

Volume

364

Issue

6439

Start / End Page

458 / 464

Related Subject Headings

  • Stereolithography
  • Polymerization
  • Mice, Nude
  • Mice
  • Lung Injury
  • Liver
  • Light
  • Hydrogels
  • Humans
  • General Science & Technology