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Epirubicin: is it like doxorubicin in breast cancer? A clinical review.

Publication ,  Journal Article
Khasraw, M; Bell, R; Dang, C
Published in: Breast
April 2012

Anthracyclines are among the most effective chemotherapy treatments available for various types of cancer. The anthracyclines commonly used in treatment of breast cancer are either epirubicin or doxorubicin. Epirubicin is an epimer of doxorubicin with important role in the chemotherapy treatment of both early and metastatic breast cancer. The efficacy of epirubicin is similar to doxorubicin while epirubicin has a different toxicity profile particularly in regard to cardiotoxicity. Epirubicin has been incorporated into most of the anthracycline containing chemotherapy combinations in well-conducted clinical trials involving large numbers of patients. It has also been investigated in studies involving the administration of epirubicin in dose-dense chemotherapy schedules. Short term follow up of dose-dense clinical trials demonstrated safety comparable to that of doxorubicin. This review summarizes published clinical trials investigating epirubicin in the treatment of early and advanced breast cancer.

Duke Scholars

Published In

Breast

DOI

EISSN

1532-3080

Publication Date

April 2012

Volume

21

Issue

2

Start / End Page

142 / 149

Location

Netherlands

Related Subject Headings

  • Oncology & Carcinogenesis
  • Humans
  • Female
  • Epirubicin
  • Doxorubicin
  • Breast Neoplasms
  • Antibiotics, Antineoplastic
  • 3211 Oncology and carcinogenesis
  • 3202 Clinical sciences
  • 1117 Public Health and Health Services
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Khasraw, M., Bell, R., & Dang, C. (2012). Epirubicin: is it like doxorubicin in breast cancer? A clinical review. Breast, 21(2), 142–149. https://doi.org/10.1016/j.breast.2011.12.012
Khasraw, Mustafa, Richard Bell, and Chau Dang. “Epirubicin: is it like doxorubicin in breast cancer? A clinical review.Breast 21, no. 2 (April 2012): 142–49. https://doi.org/10.1016/j.breast.2011.12.012.
Khasraw M, Bell R, Dang C. Epirubicin: is it like doxorubicin in breast cancer? A clinical review. Breast. 2012 Apr;21(2):142–9.
Khasraw, Mustafa, et al. “Epirubicin: is it like doxorubicin in breast cancer? A clinical review.Breast, vol. 21, no. 2, Apr. 2012, pp. 142–49. Pubmed, doi:10.1016/j.breast.2011.12.012.
Khasraw M, Bell R, Dang C. Epirubicin: is it like doxorubicin in breast cancer? A clinical review. Breast. 2012 Apr;21(2):142–149.
Journal cover image

Published In

Breast

DOI

EISSN

1532-3080

Publication Date

April 2012

Volume

21

Issue

2

Start / End Page

142 / 149

Location

Netherlands

Related Subject Headings

  • Oncology & Carcinogenesis
  • Humans
  • Female
  • Epirubicin
  • Doxorubicin
  • Breast Neoplasms
  • Antibiotics, Antineoplastic
  • 3211 Oncology and carcinogenesis
  • 3202 Clinical sciences
  • 1117 Public Health and Health Services