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Modification of Poly(propylene fumarate)-Bioglass Composites with Peptide Conjugates to Enhance Bioactivity.

Publication ,  Journal Article
Xu, Y; Luong, D; Walker, JM; Dean, D; Becker, ML
Published in: Biomacromolecules
October 2017

Poly(propylene fumarate) (PPF) has been highlighted as one of the most promising materials for bone regeneration. Despite the promising advantages of using polymer scaffolds for biomedical applications, their inherent lack of bioactivity has limited their clinical application. In this study, PPF was successfully functionalized with Bioglass and a novel catechol-bearing peptide bioconjugate containing bioactive short peptide sequences of basic fibroblast growth factor, bone morphogenetic protein 2, and osteogenic growth peptide. The binding affinity was assessed to be around 110 nmol/cm2 with the Bioglass content at 10 wt %. Fluorescence imaging studies show that the catechol-bearing modular peptide binds preferentially to the Bioglass. A 4 week in vitro cell study using human mesenchymal stem cells showed that cell adhesion, spreading, proliferation, and osteogenic differentiation at both gene and protein levels were all improved by the introduction of peptides, demonstrating the potential approach of dually functionalized polymers for bone regeneration.

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Published In

Biomacromolecules

DOI

EISSN

1526-4602

ISSN

1525-7797

Publication Date

October 2017

Volume

18

Issue

10

Start / End Page

3168 / 3177

Related Subject Headings

  • Tissue Scaffolds
  • Protein Binding
  • Polypropylenes
  • Polymers
  • Peptides
  • Mesenchymal Stem Cells
  • Intercellular Signaling Peptides and Proteins
  • Humans
  • Histones
  • Fibroblast Growth Factor 2
 

Citation

APA
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ICMJE
MLA
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Xu, Y., Luong, D., Walker, J. M., Dean, D., & Becker, M. L. (2017). Modification of Poly(propylene fumarate)-Bioglass Composites with Peptide Conjugates to Enhance Bioactivity. Biomacromolecules, 18(10), 3168–3177. https://doi.org/10.1021/acs.biomac.7b00828
Xu, Yanyi, Derek Luong, Jason M. Walker, David Dean, and Matthew L. Becker. “Modification of Poly(propylene fumarate)-Bioglass Composites with Peptide Conjugates to Enhance Bioactivity.Biomacromolecules 18, no. 10 (October 2017): 3168–77. https://doi.org/10.1021/acs.biomac.7b00828.
Xu Y, Luong D, Walker JM, Dean D, Becker ML. Modification of Poly(propylene fumarate)-Bioglass Composites with Peptide Conjugates to Enhance Bioactivity. Biomacromolecules. 2017 Oct;18(10):3168–77.
Xu, Yanyi, et al. “Modification of Poly(propylene fumarate)-Bioglass Composites with Peptide Conjugates to Enhance Bioactivity.Biomacromolecules, vol. 18, no. 10, Oct. 2017, pp. 3168–77. Epmc, doi:10.1021/acs.biomac.7b00828.
Xu Y, Luong D, Walker JM, Dean D, Becker ML. Modification of Poly(propylene fumarate)-Bioglass Composites with Peptide Conjugates to Enhance Bioactivity. Biomacromolecules. 2017 Oct;18(10):3168–3177.
Journal cover image

Published In

Biomacromolecules

DOI

EISSN

1526-4602

ISSN

1525-7797

Publication Date

October 2017

Volume

18

Issue

10

Start / End Page

3168 / 3177

Related Subject Headings

  • Tissue Scaffolds
  • Protein Binding
  • Polypropylenes
  • Polymers
  • Peptides
  • Mesenchymal Stem Cells
  • Intercellular Signaling Peptides and Proteins
  • Humans
  • Histones
  • Fibroblast Growth Factor 2