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Post-assembly derivatization of electrospun nanofibers via strain-promoted azide alkyne cycloaddition.

Publication ,  Journal Article
Zheng, J; Liu, K; Reneker, DH; Becker, ML
Published in: Journal of the American Chemical Society
October 2012

A primary amine-derivatized 4-dibenzocyclooctynol (DIBO) was used to initiate the ring-opening polymerization of poly(γ-benzyl-L-glutamate) (DIBO-PBLG). This initiator yields well-defined PBLG polymers functionalized with DIBO at the chain termini. The DIBO end group further survives an electrospinning process that yields nanofibers that were then derivatized post-assembly with azide-functionalized gold nanoparticles. The availability of DIBO on the surface of the fibers is substantiated by fluorescence, SEM, and TEM measurements. Post-assembly functionalization of nanofiber constructs with bioactive groups can be facilitated easily using this process.

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Published In

Journal of the American Chemical Society

DOI

EISSN

1520-5126

ISSN

0002-7863

Publication Date

October 2012

Volume

134

Issue

41

Start / End Page

17274 / 17277

Related Subject Headings

  • Polyglutamic Acid
  • Nanofibers
  • Molecular Structure
  • General Chemistry
  • Electrochemical Techniques
  • Cyclization
  • Azides
  • Alkynes
  • 40 Engineering
  • 34 Chemical sciences
 

Citation

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Zheng, J., Liu, K., Reneker, D. H., & Becker, M. L. (2012). Post-assembly derivatization of electrospun nanofibers via strain-promoted azide alkyne cycloaddition. Journal of the American Chemical Society, 134(41), 17274–17277. https://doi.org/10.1021/ja307647x
Zheng, Jukuan, Kaiyi Liu, Darrell H. Reneker, and Matthew L. Becker. “Post-assembly derivatization of electrospun nanofibers via strain-promoted azide alkyne cycloaddition.Journal of the American Chemical Society 134, no. 41 (October 2012): 17274–77. https://doi.org/10.1021/ja307647x.
Zheng J, Liu K, Reneker DH, Becker ML. Post-assembly derivatization of electrospun nanofibers via strain-promoted azide alkyne cycloaddition. Journal of the American Chemical Society. 2012 Oct;134(41):17274–7.
Zheng, Jukuan, et al. “Post-assembly derivatization of electrospun nanofibers via strain-promoted azide alkyne cycloaddition.Journal of the American Chemical Society, vol. 134, no. 41, Oct. 2012, pp. 17274–77. Epmc, doi:10.1021/ja307647x.
Zheng J, Liu K, Reneker DH, Becker ML. Post-assembly derivatization of electrospun nanofibers via strain-promoted azide alkyne cycloaddition. Journal of the American Chemical Society. 2012 Oct;134(41):17274–17277.
Journal cover image

Published In

Journal of the American Chemical Society

DOI

EISSN

1520-5126

ISSN

0002-7863

Publication Date

October 2012

Volume

134

Issue

41

Start / End Page

17274 / 17277

Related Subject Headings

  • Polyglutamic Acid
  • Nanofibers
  • Molecular Structure
  • General Chemistry
  • Electrochemical Techniques
  • Cyclization
  • Azides
  • Alkynes
  • 40 Engineering
  • 34 Chemical sciences