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An assessment of the effects of shell cross-linked nanoparticle size, core composition, and surface PEGylation on in vivo biodistribution.

Publication ,  Journal Article
Sun, X; Rossin, R; Turner, JL; Becker, ML; Joralemon, MJ; Welch, MJ; Wooley, KL
Published in: Biomacromolecules
September 2005

Amphiphilic core-shell nanoparticles have drawn considerable interest in biomedical applications. The precise control over their physicochemical parameters and the ability to attach various ligands within specific domains suggest shell cross-linked (SCK) nanoparticles may be used as multi-/polyvalent scaffolds for drug delivery. In this study, the biodistribution of four SCKs, differing in size, core composition, and surface PEGylation, was evaluated. To facilitate in-vivo tracking of the SCKs, the positron-emitting radionuclide copper-64 was used. By using biodistribution and microPET imaging approaches, we found that small diameter (18 nm) SCKs possessing a polystyrene core showed the most favorable biological behavior in terms of prolonged blood retention and low liver accumulation. The data demonstrated that both core composition, which influenced the SCK flexibility and shape adaptability, and hydrodynamic diameter of the nanoparticle play important roles in the respective biodistributions. Surface modification with poly(ethylene glycol) (PEG) had no noticeable effects on SCK behavior.

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Published In

Biomacromolecules

DOI

EISSN

1526-4602

ISSN

1525-7797

Publication Date

September 2005

Volume

6

Issue

5

Start / End Page

2541 / 2554

Related Subject Headings

  • Time Factors
  • Rats, Sprague-Dawley
  • Rats
  • Protein Structure, Tertiary
  • Positron-Emission Tomography
  • Polystyrenes
  • Polymers
  • Polymers
  • Polyethylene Glycols
  • Particle Size
 

Citation

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Sun, X., Rossin, R., Turner, J. L., Becker, M. L., Joralemon, M. J., Welch, M. J., & Wooley, K. L. (2005). An assessment of the effects of shell cross-linked nanoparticle size, core composition, and surface PEGylation on in vivo biodistribution. Biomacromolecules, 6(5), 2541–2554. https://doi.org/10.1021/bm050260e
Sun, Xiankai, Raffaella Rossin, Jeffrey L. Turner, Matthew L. Becker, Maisie J. Joralemon, Michael J. Welch, and Karen L. Wooley. “An assessment of the effects of shell cross-linked nanoparticle size, core composition, and surface PEGylation on in vivo biodistribution.Biomacromolecules 6, no. 5 (September 2005): 2541–54. https://doi.org/10.1021/bm050260e.
Sun X, Rossin R, Turner JL, Becker ML, Joralemon MJ, Welch MJ, et al. An assessment of the effects of shell cross-linked nanoparticle size, core composition, and surface PEGylation on in vivo biodistribution. Biomacromolecules. 2005 Sep;6(5):2541–54.
Sun, Xiankai, et al. “An assessment of the effects of shell cross-linked nanoparticle size, core composition, and surface PEGylation on in vivo biodistribution.Biomacromolecules, vol. 6, no. 5, Sept. 2005, pp. 2541–54. Epmc, doi:10.1021/bm050260e.
Sun X, Rossin R, Turner JL, Becker ML, Joralemon MJ, Welch MJ, Wooley KL. An assessment of the effects of shell cross-linked nanoparticle size, core composition, and surface PEGylation on in vivo biodistribution. Biomacromolecules. 2005 Sep;6(5):2541–2554.
Journal cover image

Published In

Biomacromolecules

DOI

EISSN

1526-4602

ISSN

1525-7797

Publication Date

September 2005

Volume

6

Issue

5

Start / End Page

2541 / 2554

Related Subject Headings

  • Time Factors
  • Rats, Sprague-Dawley
  • Rats
  • Protein Structure, Tertiary
  • Positron-Emission Tomography
  • Polystyrenes
  • Polymers
  • Polymers
  • Polyethylene Glycols
  • Particle Size