CRISPR/Cas9: at the cutting edge of hepatology.
Journal articles
- Journal Article, Review
Pankowicz, FP; Jarrett, KE; Lagor, WR; Bissig, K-D
Published in: Gut
July 2017
Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9 genome engineering has revolutionised biomedical science and we are standing on the cusp of medical transformation. The therapeutic potential of this technology is tremendous, however, its translation to the clinic will be challenging. In this article, we review recent progress using this genome editing technology and explore its potential uses in studying and treating diseases of the liver. We discuss the development of new research tools and animal models as well as potential clinical applications, strategies and challenges.
Duke Scholars
Altmetric Attention Stats
Dimensions Citation Stats
Published In
Gut
DOI
EISSN
1468-3288
Publication Date
July 2017
Volume
66
Issue
7
Start / End Page
1329 / 1340
Location
England
Related Subject Headings
- Recombinational DNA Repair
- Mutation
- Mutagenesis
- Humans
- Hepatitis B virus
- Genetic Therapy
- Gene Transfer Techniques
- Gene Targeting
- Gene Editing
- Gastroenterology & Hepatology
Citation
APA
Chicago
ICMJE
MLA
NLM
Pankowicz, F. P., Jarrett, K. E., Lagor, W. R., & Bissig, K.-D. (2017). CRISPR/Cas9: at the cutting edge of hepatology. Gut, 66(7), 1329–1340. https://doi.org/10.1136/gutjnl-2016-313565
Pankowicz, Francis P., Kelsey E. Jarrett, William R. Lagor, and Karl-Dimiter Bissig. “CRISPR/Cas9: at the cutting edge of hepatology.” Gut 66, no. 7 (July 2017): 1329–40. https://doi.org/10.1136/gutjnl-2016-313565.
Pankowicz FP, Jarrett KE, Lagor WR, Bissig K-D. CRISPR/Cas9: at the cutting edge of hepatology. Gut. 2017 Jul;66(7):1329–40.
Pankowicz, Francis P., et al. “CRISPR/Cas9: at the cutting edge of hepatology.” Gut, vol. 66, no. 7, July 2017, pp. 1329–40. Pubmed, doi:10.1136/gutjnl-2016-313565.
Pankowicz FP, Jarrett KE, Lagor WR, Bissig K-D. CRISPR/Cas9: at the cutting edge of hepatology. Gut. 2017 Jul;66(7):1329–1340.
Published In
Gut
DOI
EISSN
1468-3288
Publication Date
July 2017
Volume
66
Issue
7
Start / End Page
1329 / 1340
Location
England
Related Subject Headings
- Recombinational DNA Repair
- Mutation
- Mutagenesis
- Humans
- Hepatitis B virus
- Genetic Therapy
- Gene Transfer Techniques
- Gene Targeting
- Gene Editing
- Gastroenterology & Hepatology