Karl-Dimiter Bissig
Chen Family Associate Professor of Pediatrics
Our group is interested in diseases of the liver, ranging from viral hepatitis to metabolic liver disorders and liver cancer. The lab specializes in human liver chimeric mice and created the first xenograft model for metabolic liver disease as well as a novel patient derived cancer model. We use these next generation humanized mouse models to develop new therapeutic approaches, such as metabolic pathway reprogramming - a CRISPR based gene therapy approach.
Current Research Interests
Our group is interested in diseases of the liver, ranging from viral hepatitis to metabolic liver disorders and liver cancer. The lab specializes in human liver chimeric mice and created the first xenograft model for metabolic liver disease as well as a novel patient derived cancer model. We use these next generation humanized mouse models to develop new therapeutic approaches, such as metabolic pathway reprogramming - a CRISPR based gene therapy approach.
Current Appointments & Affiliations
- Chen Family Associate Professor of Pediatrics, Pediatrics, Medical Genetics, Pediatrics 2022
- Associate Professor in Pediatrics, Pediatrics, Medical Genetics, Pediatrics 2021
- Associate Professor in Pharmacology and Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2021
- Associate Professor of Biomedical Engineering, Biomedical Engineering, Pratt School of Engineering 2022
- Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2019
- Affiliate of the Duke Regeneration Center, Regeneration Next Initiative, Basic Science Departments 2021
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