Overview
Our group is interested in diseases of the liver, ranging from viral hepatitis to metabolic liver disorders and liver cancer. The lab specializes in human liver chimeric mice and created the first xenograft model for metabolic liver disease as well as a novel patient derived cancer model. We use these next generation humanized mouse models to develop new therapeutic approaches, such as metabolic pathway reprogramming - a CRISPR based gene therapy approach.
Current Appointments & Affiliations
Chen Family Associate Professor of Pediatrics
·
2022 - Present
Pediatrics, Medical Genetics,
Pediatrics
Associate Professor in Pediatrics
·
2021 - Present
Pediatrics, Medical Genetics,
Pediatrics
Associate Professor in Pharmacology and Cancer Biology
·
2021 - Present
Pharmacology & Cancer Biology,
Basic Science Departments
Associate Professor of Biomedical Engineering
·
2022 - Present
Biomedical Engineering,
Pratt School of Engineering
Member of the Duke Cancer Institute
·
2019 - Present
Duke Cancer Institute,
Institutes and Centers
Affiliate of the Duke Regeneration Center
·
2021 - Present
Duke Regeneration Center,
Basic Science Departments
Recent Grants
Targeting Hepatocyte Senescence to Improve NAFLD
ResearchAdvisor · Awarded by National Institutes of Health · 2024 - 2029Medical Scientist Training Program
Inst. Training Prgm or CMEPreceptor · Awarded by National Institute of General Medical Sciences · 2022 - 2027Duke Training Grant in Digestive Diseases and Nutrition
Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 1988 - 2027View All Grants
Education, Training & Certifications
Universitat Bern (Switzerland) ·
2000
MD./PhD.