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Karl-Dimiter Bissig

Chen Family Associate Professor of Pediatrics
Pediatrics, Medical Genetics

Overview


Our group is interested in diseases of the liver, ranging from viral hepatitis to metabolic liver disorders and liver cancer. The lab specializes in human liver chimeric mice and created the first xenograft model for metabolic liver disease as well as a novel patient derived cancer model. We use these next generation humanized mouse models to develop new therapeutic approaches, such as metabolic pathway reprogramming - a CRISPR based gene therapy approach.

Current Appointments & Affiliations


Chen Family Associate Professor of Pediatrics · 2022 - Present Pediatrics, Medical Genetics, Pediatrics
Associate Professor in Pediatrics · 2021 - Present Pediatrics, Medical Genetics, Pediatrics
Associate Professor in Pharmacology and Cancer Biology · 2021 - Present Pharmacology & Cancer Biology, Basic Science Departments
Associate Professor of Biomedical Engineering · 2022 - Present Biomedical Engineering, Pratt School of Engineering
Member of the Duke Cancer Institute · 2019 - Present Duke Cancer Institute, Institutes and Centers
Affiliate of the Duke Regeneration Center · 2021 - Present Regeneration Next Initiative, Basic Science Departments

Education, Training & Certifications


Universitat Bern (Switzerland) · 2000 MD./PhD.