Research Interests
Our group is interested in diseases of the liver, ranging from viral hepatitis to metabolic liver disorders and liver cancer. The lab specializes in human liver chimeric mice and created the first xenograft model for metabolic liver disease as well as a novel patient derived cancer model. We use these next generation humanized mouse models to develop new therapeutic approaches, such as metabolic pathway reprogramming - a CRISPR based gene therapy approach.
Selected Grants
Targeting Hepatocyte Senescence to Improve NAFLD
ResearchAdvisor · Awarded by National Institutes of Health · 2024 - 2029Medical Scientist Training Program
Inst. Training Prgm or CMEPreceptor · Awarded by National Institute of General Medical Sciences · 2022 - 2027Duke Training Grant in Digestive Diseases and Nutrition
Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 1988 - 2027Gene therapy for glycogen storage disease type III
ResearchCo Investigator · Awarded by National Institutes of Health · 2022 - 2027Dissecting AAV silencing in humanized mice
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2023 - 2027Targeting Hepatocyte Senescence to Improve NAFLD
ResearchAdvisor · Awarded by National Institutes of Health · 2024 - 2029Medical Scientist Training Program
Inst. Training Prgm or CMEPreceptor · Awarded by National Institute of General Medical Sciences · 2022 - 2027Duke Training Grant in Digestive Diseases and Nutrition
Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 1988 - 2027Gene therapy for glycogen storage disease type III
ResearchCo Investigator · Awarded by National Institutes of Health · 2022 - 2027Dissecting AAV silencing in humanized mice
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2023 - 2027Transplant liver screening for xenograft models of lipid disorders
ResearchPrincipal Investigator · Awarded by Spark Therapeutics, Inc. · 2024 - 2026Genetic and Genomics Training Grant
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2020 - 2025Mechanisms of Liver Toxicity of Anti-Depressant Duloxetine
ResearchPrincipal Investigator · Awarded by Baylor College of Medicine · 2023 - 2024Physiological Dissection of the Mevalonate Pathway
ResearchPrincipal Investigator · Awarded by Baylor College of Medicine · 2020 - 2024Therapeutic pathway reprogramming for metabolic liver disease
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2018 - 2022Therapeutic potential of CRISPR/Cas9 genome engineering in humanized mouse
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2020 - 2022External Relationships
- Alnylam Pharmaceutical, Inc.
- Avachrome
- Precision Bioscience
- Tune Therapeutics
- Vesta Therapeutics
This faculty member (or a member of their immediate family) has reported outside activities with the companies, institutions, or organizations listed above. This information is available to institutional leadership and, when appropriate, management plans are in place to address potential conflicts of interest.