Tetrathiomolybdate inhibition of the Enterococcus hirae CopB copper ATPase.
Journal articles
- Journal Article
Bissig, KD; Voegelin, TC; Solioz, M
Published in: FEBS Lett
November 2, 2001
Tetrathiomolybdate (TTM) avidly interacts with copper and has recently been employed to reduce excess copper in patients with Wilson disease. We found that TTM inhibits the purified Enterococcus hirae CopB copper ATPase with an IC(50) of 34 nM. Dithiomolybdate and trithiomolybdate, which commonly contaminate TTM, inhibited the copper ATPases with similar potency. Inhibition could be reversed by copper or silver, suggesting inhibition by substrate binding. These findings for the first time allowed an estimate of the high affinity of CopB for copper and silver. TTM is a new tool for the study of copper ATPases.
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Published In
FEBS Lett
DOI
ISSN
0014-5793
Publication Date
November 2, 2001
Volume
507
Issue
3
Start / End Page
367 / 370
Location
England
Related Subject Headings
- Silver
- Quinolines
- Molybdenum
- Inhibitory Concentration 50
- Enzyme Inhibitors
- Copper Transport Proteins
- Copper
- Cation Transport Proteins
- Biochemistry & Molecular Biology
- Adenosine Triphosphatases
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Bissig, K. D., Voegelin, T. C., & Solioz, M. (2001). Tetrathiomolybdate inhibition of the Enterococcus hirae CopB copper ATPase. FEBS Lett, 507(3), 367–370. https://doi.org/10.1016/s0014-5793(01)03009-5
Bissig, K. D., T. C. Voegelin, and M. Solioz. “Tetrathiomolybdate inhibition of the Enterococcus hirae CopB copper ATPase.” FEBS Lett 507, no. 3 (November 2, 2001): 367–70. https://doi.org/10.1016/s0014-5793(01)03009-5.
Bissig KD, Voegelin TC, Solioz M. Tetrathiomolybdate inhibition of the Enterococcus hirae CopB copper ATPase. FEBS Lett. 2001 Nov 2;507(3):367–70.
Bissig, K. D., et al. “Tetrathiomolybdate inhibition of the Enterococcus hirae CopB copper ATPase.” FEBS Lett, vol. 507, no. 3, Nov. 2001, pp. 367–70. Pubmed, doi:10.1016/s0014-5793(01)03009-5.
Bissig KD, Voegelin TC, Solioz M. Tetrathiomolybdate inhibition of the Enterococcus hirae CopB copper ATPase. FEBS Lett. 2001 Nov 2;507(3):367–370.
Published In
FEBS Lett
DOI
ISSN
0014-5793
Publication Date
November 2, 2001
Volume
507
Issue
3
Start / End Page
367 / 370
Location
England
Related Subject Headings
- Silver
- Quinolines
- Molybdenum
- Inhibitory Concentration 50
- Enzyme Inhibitors
- Copper Transport Proteins
- Copper
- Cation Transport Proteins
- Biochemistry & Molecular Biology
- Adenosine Triphosphatases