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Direct observation of kinesin stepping by optical trapping interferometry.

Publication ,  Journal Article
Svoboda, K; Schmidt, CF; Schnapp, BJ; Block, SM
Published in: Nature
October 1993

Do biological motors move with regular steps? To address this question, we constructed instrumentation with the spatial and temporal sensitivity to resolve movement on a molecular scale. We deposited silica beads carrying single molecules of the motor protein kinesin on microtubules using optical tweezers and analysed their motion under controlled loads by interferometry. We find that kinesin moves with 8-nm steps.

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Published In

Nature

DOI

EISSN

1476-4687

ISSN

0028-0836

Publication Date

October 1993

Volume

365

Issue

6448

Start / End Page

721 / 727

Related Subject Headings

  • Silicon Dioxide
  • Movement
  • Microtubules
  • Microspheres
  • Light
  • Lasers
  • Kinesins
  • Interferometry
  • General Science & Technology
  • Decapodiformes
 

Citation

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Svoboda, K., Schmidt, C. F., Schnapp, B. J., & Block, S. M. (1993). Direct observation of kinesin stepping by optical trapping interferometry. Nature, 365(6448), 721–727. https://doi.org/10.1038/365721a0
Svoboda, K., C. F. Schmidt, B. J. Schnapp, and S. M. Block. “Direct observation of kinesin stepping by optical trapping interferometry.Nature 365, no. 6448 (October 1993): 721–27. https://doi.org/10.1038/365721a0.
Svoboda K, Schmidt CF, Schnapp BJ, Block SM. Direct observation of kinesin stepping by optical trapping interferometry. Nature. 1993 Oct;365(6448):721–7.
Svoboda, K., et al. “Direct observation of kinesin stepping by optical trapping interferometry.Nature, vol. 365, no. 6448, Oct. 1993, pp. 721–27. Epmc, doi:10.1038/365721a0.
Svoboda K, Schmidt CF, Schnapp BJ, Block SM. Direct observation of kinesin stepping by optical trapping interferometry. Nature. 1993 Oct;365(6448):721–727.
Journal cover image

Published In

Nature

DOI

EISSN

1476-4687

ISSN

0028-0836

Publication Date

October 1993

Volume

365

Issue

6448

Start / End Page

721 / 727

Related Subject Headings

  • Silicon Dioxide
  • Movement
  • Microtubules
  • Microspheres
  • Light
  • Lasers
  • Kinesins
  • Interferometry
  • General Science & Technology
  • Decapodiformes