Direct observation of kinesin stepping by optical trapping interferometry.
Publication
, Journal Article
Svoboda, K; Schmidt, CF; Schnapp, BJ; Block, SM
Published in: Nature
October 1993
Do biological motors move with regular steps? To address this question, we constructed instrumentation with the spatial and temporal sensitivity to resolve movement on a molecular scale. We deposited silica beads carrying single molecules of the motor protein kinesin on microtubules using optical tweezers and analysed their motion under controlled loads by interferometry. We find that kinesin moves with 8-nm steps.
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Published In
Nature
DOI
EISSN
1476-4687
ISSN
0028-0836
Publication Date
October 1993
Volume
365
Issue
6448
Start / End Page
721 / 727
Related Subject Headings
- Silicon Dioxide
- Movement
- Microtubules
- Microspheres
- Light
- Lasers
- Kinesins
- Interferometry
- General Science & Technology
- Decapodiformes
Citation
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Chicago
ICMJE
MLA
NLM
Svoboda, K., Schmidt, C. F., Schnapp, B. J., & Block, S. M. (1993). Direct observation of kinesin stepping by optical trapping interferometry. Nature, 365(6448), 721–727. https://doi.org/10.1038/365721a0
Svoboda, K., C. F. Schmidt, B. J. Schnapp, and S. M. Block. “Direct observation of kinesin stepping by optical trapping interferometry.” Nature 365, no. 6448 (October 1993): 721–27. https://doi.org/10.1038/365721a0.
Svoboda K, Schmidt CF, Schnapp BJ, Block SM. Direct observation of kinesin stepping by optical trapping interferometry. Nature. 1993 Oct;365(6448):721–7.
Svoboda, K., et al. “Direct observation of kinesin stepping by optical trapping interferometry.” Nature, vol. 365, no. 6448, Oct. 1993, pp. 721–27. Epmc, doi:10.1038/365721a0.
Svoboda K, Schmidt CF, Schnapp BJ, Block SM. Direct observation of kinesin stepping by optical trapping interferometry. Nature. 1993 Oct;365(6448):721–727.
Published In
Nature
DOI
EISSN
1476-4687
ISSN
0028-0836
Publication Date
October 1993
Volume
365
Issue
6448
Start / End Page
721 / 727
Related Subject Headings
- Silicon Dioxide
- Movement
- Microtubules
- Microspheres
- Light
- Lasers
- Kinesins
- Interferometry
- General Science & Technology
- Decapodiformes