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Urine gastrin-releasing peptide in the first week correlates with bronchopulmonary dysplasia and post-prematurity respiratory disease.

Publication ,  Journal Article
Voynow, JA; Fisher, K; Sunday, ME; Cotten, CM; Hamvas, A; Hendricks-Muñoz, KD; Poindexter, BB; Pryhuber, GS; Ren, CL; Ryan, RM; Sharp, JK ...
Published in: Pediatr Pulmonol
April 2020

RATIONALE: Bronchopulmonary dysplasia (BPD) is associated with post-prematurity respiratory disease (PRD) in survivors of extreme preterm birth. Identifying early biomarkers that correlate with later development of BPD and PRD may provide insights for intervention. In a preterm baboon model, elevated gastrin-releasing peptide (GRP) is associated with BPD, and GRP inhibition mitigates BPD occurrence. OBJECTIVE: We performed a prospective cohort study to investigate whether urine GRP levels obtained in the first postnatal week were associated with BPD, PRD, and other urinary biomarkers of oxidative stress. METHODS: Extremely low gestational age infants (23-28 completed weeks) were enrolled in a US multicenter observational study, The Prematurity and Respiratory Outcomes Program (http://clinicaltrials.gov/ct2/show/NCT01435187). We used multivariable logistic regression to examine the association between urine GRP in the first postnatal week and multiple respiratory outcomes: BPD, defined as supplemental oxygen use at 36 + 0 weeks postmenstrual age, and post-PRD, defined by positive quarterly surveys for increased medical utilization over the first year (PRD score). RESULTS: A total of 109 of 257 (42%) infants had BPD, and 120 of 217 (55%) had PRD. On adjusted analysis, GRP level more than 80 was associated with BPD (adjusted odds ratio [aOR], 1.83; 95% confidence interval [CI], 1.03-3.25) and positive PRD score (aOR, 2.46; 95% CI, 1.35-4.48). Urine GRP levels correlated with duration of NICU ventilatory and oxygen support and with biomarkers of oxidative stress: allantoin and 8-hydroxydeoxyguanosine. CONCLUSIONS: Urine GRP in the first postnatal week was associated with concurrent urine biomarkers of oxidative stress and with later diagnoses of BPD and PRD.

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Published In

Pediatr Pulmonol

DOI

EISSN

1099-0496

Publication Date

April 2020

Volume

55

Issue

4

Start / End Page

899 / 908

Location

United States

Related Subject Headings

  • Respiratory Tract Diseases
  • Respiratory System
  • Respiration Disorders
  • Prospective Studies
  • Male
  • Logistic Models
  • Infant, Premature, Diseases
  • Infant, Newborn
  • Infant, Extremely Premature
  • Humans
 

Citation

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Voynow, J. A., Fisher, K., Sunday, M. E., Cotten, C. M., Hamvas, A., Hendricks-Muñoz, K. D., … Davis, S. D. (2020). Urine gastrin-releasing peptide in the first week correlates with bronchopulmonary dysplasia and post-prematurity respiratory disease. Pediatr Pulmonol, 55(4), 899–908. https://doi.org/10.1002/ppul.24665
Voynow, Judith A., Kimberley Fisher, Mary E. Sunday, Charles M. Cotten, Aaron Hamvas, Karen D. Hendricks-Muñoz, Brenda B. Poindexter, et al. “Urine gastrin-releasing peptide in the first week correlates with bronchopulmonary dysplasia and post-prematurity respiratory disease.Pediatr Pulmonol 55, no. 4 (April 2020): 899–908. https://doi.org/10.1002/ppul.24665.
Voynow JA, Fisher K, Sunday ME, Cotten CM, Hamvas A, Hendricks-Muñoz KD, et al. Urine gastrin-releasing peptide in the first week correlates with bronchopulmonary dysplasia and post-prematurity respiratory disease. Pediatr Pulmonol. 2020 Apr;55(4):899–908.
Voynow, Judith A., et al. “Urine gastrin-releasing peptide in the first week correlates with bronchopulmonary dysplasia and post-prematurity respiratory disease.Pediatr Pulmonol, vol. 55, no. 4, Apr. 2020, pp. 899–908. Pubmed, doi:10.1002/ppul.24665.
Voynow JA, Fisher K, Sunday ME, Cotten CM, Hamvas A, Hendricks-Muñoz KD, Poindexter BB, Pryhuber GS, Ren CL, Ryan RM, Sharp JK, Young SP, Zhang H, Greenberg RG, Herring AH, Davis SD. Urine gastrin-releasing peptide in the first week correlates with bronchopulmonary dysplasia and post-prematurity respiratory disease. Pediatr Pulmonol. 2020 Apr;55(4):899–908.
Journal cover image

Published In

Pediatr Pulmonol

DOI

EISSN

1099-0496

Publication Date

April 2020

Volume

55

Issue

4

Start / End Page

899 / 908

Location

United States

Related Subject Headings

  • Respiratory Tract Diseases
  • Respiratory System
  • Respiration Disorders
  • Prospective Studies
  • Male
  • Logistic Models
  • Infant, Premature, Diseases
  • Infant, Newborn
  • Infant, Extremely Premature
  • Humans