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Comparison of Cartilage Mechanical Properties Measured During Creep and Recovery.

Publication ,  Journal Article
Cutcliffe, HC; DeFrate, LE
Published in: Sci Rep
January 31, 2020

The diagnosis of osteoarthritis (OA) currently depends on the presence of pain and radiographic imaging findings, which generally do not present until later stages of the disease when the condition is difficult to treat. Therefore, earlier detection of OA pathology is needed for improved disease management. Ex vivo cartilage studies indicate that changes in the mechanical function of cartilage occur as degeneration progresses during OA. Thus, measurement of the in vivo cartilage mechanical response may serve as an earlier indicator of OA pathology. Though mechanical characterization is classically performed during loading, the unloading (recovery) response of cartilage may also enable determination of mechanical response. Therefore, the purpose of this study was to validate the use of the recovery response for mechanical characterization of cartilage in a controlled, ex vivo environment. To do so, confined compression creep and recovery tests were conducted on cartilage explants (N = 10), and the resulting mechanical properties from both the creep and recovery phases were compared. No statistically significant differences were found in the mechanical properties between the two phases, reinforcing the hypothesis that unloading (recovery) may be a good surrogate for loading.

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Published In

Sci Rep

DOI

EISSN

2045-2322

Publication Date

January 31, 2020

Volume

10

Issue

1

Start / End Page

1547

Location

England

Related Subject Headings

  • Tibia
  • Swine
  • Stress, Mechanical
  • Osteoarthritis
  • Organ Culture Techniques
  • Humans
  • Femur
  • Extracellular Matrix
  • Disease Progression
  • Cells, Cultured
 

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Cutcliffe, H. C., & DeFrate, L. E. (2020). Comparison of Cartilage Mechanical Properties Measured During Creep and Recovery. Sci Rep, 10(1), 1547. https://doi.org/10.1038/s41598-020-58220-2
Cutcliffe, Hattie C., and Louis E. DeFrate. “Comparison of Cartilage Mechanical Properties Measured During Creep and Recovery.Sci Rep 10, no. 1 (January 31, 2020): 1547. https://doi.org/10.1038/s41598-020-58220-2.
Cutcliffe HC, DeFrate LE. Comparison of Cartilage Mechanical Properties Measured During Creep and Recovery. Sci Rep. 2020 Jan 31;10(1):1547.
Cutcliffe, Hattie C., and Louis E. DeFrate. “Comparison of Cartilage Mechanical Properties Measured During Creep and Recovery.Sci Rep, vol. 10, no. 1, Jan. 2020, p. 1547. Pubmed, doi:10.1038/s41598-020-58220-2.
Cutcliffe HC, DeFrate LE. Comparison of Cartilage Mechanical Properties Measured During Creep and Recovery. Sci Rep. 2020 Jan 31;10(1):1547.

Published In

Sci Rep

DOI

EISSN

2045-2322

Publication Date

January 31, 2020

Volume

10

Issue

1

Start / End Page

1547

Location

England

Related Subject Headings

  • Tibia
  • Swine
  • Stress, Mechanical
  • Osteoarthritis
  • Organ Culture Techniques
  • Humans
  • Femur
  • Extracellular Matrix
  • Disease Progression
  • Cells, Cultured