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Gamma Gap: A Point-of-Care Test That Correlates With Disease Burden and Treatment Response in Multiple Myeloma.

Publication ,  Journal Article
Dupuis, MM; Paul, B; Loitsch, G; Mathews, P; Feinberg, D; Barak, I; Li, Z; Tuchman, SA; Kang, Y
Published in: JCO Oncol Pract
August 2020

PURPOSE: We performed a retrospective chart review on 393 patients with multiple myeloma (MM) to determine the utility of the gamma gap (GG). METHODS: We calculated the difference between a patient's total serum protein and albumin as a point-of-care test for assessing disease status in MM. RESULTS: GG is highly correlated with the level of M-spike, and the change in GG correlates with myeloma treatment response. In addition, fitted linear models were established that allow for the calculation of M-protein level from the GG within hours from blood draw. CONCLUSION: Our study has important implications in the care of MM, particularly in countries/areas with limited resources.

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Published In

JCO Oncol Pract

DOI

EISSN

2688-1535

Publication Date

August 2020

Volume

16

Issue

8

Start / End Page

e751 / e757

Location

United States

Related Subject Headings

  • Retrospective Studies
  • Point-of-Care Testing
  • Multiple Myeloma
  • Humans
  • Cost of Illness
  • 3211 Oncology and carcinogenesis
 

Citation

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Dupuis, M. M., Paul, B., Loitsch, G., Mathews, P., Feinberg, D., Barak, I., … Kang, Y. (2020). Gamma Gap: A Point-of-Care Test That Correlates With Disease Burden and Treatment Response in Multiple Myeloma. JCO Oncol Pract, 16(8), e751–e757. https://doi.org/10.1200/JOP.19.00517
Dupuis, Megan M., Barry Paul, Gavin Loitsch, Parker Mathews, Daniel Feinberg, Ian Barak, Zhiguo Li, Sascha A. Tuchman, and Yubin Kang. “Gamma Gap: A Point-of-Care Test That Correlates With Disease Burden and Treatment Response in Multiple Myeloma.JCO Oncol Pract 16, no. 8 (August 2020): e751–57. https://doi.org/10.1200/JOP.19.00517.
Dupuis MM, Paul B, Loitsch G, Mathews P, Feinberg D, Barak I, et al. Gamma Gap: A Point-of-Care Test That Correlates With Disease Burden and Treatment Response in Multiple Myeloma. JCO Oncol Pract. 2020 Aug;16(8):e751–7.
Dupuis, Megan M., et al. “Gamma Gap: A Point-of-Care Test That Correlates With Disease Burden and Treatment Response in Multiple Myeloma.JCO Oncol Pract, vol. 16, no. 8, Aug. 2020, pp. e751–57. Pubmed, doi:10.1200/JOP.19.00517.
Dupuis MM, Paul B, Loitsch G, Mathews P, Feinberg D, Barak I, Li Z, Tuchman SA, Kang Y. Gamma Gap: A Point-of-Care Test That Correlates With Disease Burden and Treatment Response in Multiple Myeloma. JCO Oncol Pract. 2020 Aug;16(8):e751–e757.

Published In

JCO Oncol Pract

DOI

EISSN

2688-1535

Publication Date

August 2020

Volume

16

Issue

8

Start / End Page

e751 / e757

Location

United States

Related Subject Headings

  • Retrospective Studies
  • Point-of-Care Testing
  • Multiple Myeloma
  • Humans
  • Cost of Illness
  • 3211 Oncology and carcinogenesis