Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., University of Michigan at Ann Arbor 2008
• Research
• 

  Selected Grants

  • Effects of PPAR agonists on response to immunomodulatory agents in patients with multiple myeloma awarded by National Institutes of Health 2019 - 2020
  • Breaking B-Cell Tolerance to Produce Antibodies that Eradicate Leukemias and Lymphomas awarded by Department of Defense 2018 - 2020
  • Pathological B Cells: Novel Strategies to Prevent and Treat Chronic GVHD awarded by National Institutes of Health 2015 - 2020
  • Pathological B Cells: Novel Strategies to Prevent and Treat Chronic GVHD awarded by National Institutes of Health 2015 - 2020
  • Methods for Discovery and Analysis of Dynamic Treatment Regimes awarded by University of North Carolina - Chapel Hill 2015 - 2020
  • Statistical/Computational Methods for Pharmacogenomics and Individualized Therapy awarded by University of North Carolina - Chapel Hill 2015 - 2020
  • The Notch2-BCR Axis: Targeting Drivers of B cell Fate in Chronic GVHD 2015 - 2019
  • Validation of a microRNA signature for the prediction, diagnosis and prognosis of acute graft-versus-host disease 2015
  • Plasma microRNAs as non-invasive biomarker for acute graft-versus-host diseases 2014 - 2015
  • Mayo Alliance Foundation Funds 2012 - 2014
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Li, Zhiguo, Jiaxing Lin, Alexander B. Sibley, Tracy Truong, Katherina C. Chua, Yu Jiang, Janice McCarthy, Deanna L. Kroetz, Andrew Allen, and Kouros Owzar. “Efficient estimation of grouped survival models..” Bmc Bioinformatics 20, no. 1 (May 28, 2019). https://doi.org/10.1186/s12859-019-2899-x.
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    • Li, Zhiguo, Xiaofei Wang, Yuan Wu, and Kouros Owzar. “Sample size calculation for studies with grouped survival data..” Stat Med 37, no. 27 (November 30, 2018): 3904–17. https://doi.org/10.1002/sim.7847.
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    • Heyman, Benjamin, David Rizzieri, David J. Adams, Carlos De Castro, Louis Diehl, Zhiguo Li, Joseph Moore, and Anne Beaven. “Phase I Study of the Combination of Bendamustine, Rituximab, and Pixantrone in Patients With Relapsed/Refractory B-cell Non-Hodgkin Lymphoma..” Clin Lymphoma Myeloma Leuk 18, no. 10 (October 2018): 679–86. https://doi.org/10.1016/j.clml.2018.07.285.
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    • Sung, Anthony D., Syed Hassan, Diana M. Cardona, Daniel Wild, Krista Rowe Nichols, Hossein Mehdikhani, Bryan Balmadrid, et al. “Late Gastrointestinal Complications of Allogeneic Hematopoietic Stem Cell Transplantation in Adults..” Biol Blood Marrow Transplant 24, no. 4 (April 2018): 734–40. https://doi.org/10.1016/j.bbmt.2017.12.772.
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    • Sibley, Alexander, Zhiguo Li, Yu Jiang, Yi-Ju Li, Cliburn Chan, Andrew Allen, and Kouros Owzar. “Facilitating the Calculation of the Efficient Score Using Symbolic Computing..” Am Stat 72, no. 2 (2018): 199–205. https://doi.org/10.1080/00031305.2017.1392361.
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    • Sivaraj, D., W. Bacon, G. D. Long, D. A. Rizzieri, M. E. Horwitz, K. M. Sullivan, Y. Kang, Z. Li, N. J. Chao, and C. Gasparetto. “High-dose BCNU/Melphalan conditioning regimen before autologous stem cell transplantation in newly diagnosed multiple myeloma..” Bone Marrow Transplant 53, no. 1 (January 2018): 34–38. https://doi.org/10.1038/bmt.2017.208.
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    • Tuchman, Sascha A., Joseph O. Moore, Carlos D. DeCastro, Zhiguo Li, Emily Sellars, Yubin Kang, Gwynn Long, and Cristina G. Gasparetto. “Phase II study of dose-attenuated bortezomib, cyclophosphamide and dexamethasone ("VCD-Lite") in very old or otherwise toxicity-vulnerable adults with newly diagnosed multiple myeloma..” J Geriatr Oncol 8, no. 3 (May 2017): 165–69. https://doi.org/10.1016/j.jgo.2017.02.004.
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    • Li, Zhiguo. “Comparison of adaptive treatment strategies based on longitudinal outcomes in sequential multiple assignment randomized trials..” Stat Med 36, no. 3 (February 10, 2017): 403–15. https://doi.org/10.1002/sim.7136.
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    • Sivaraj, Dharshan, Michael M. Green, Zhiguo Li, Anthony D. Sung, Stefanie Sarantopoulos, Yubin Kang, Gwynn D. Long, et al. “Outcomes of Maintenance Therapy with Bortezomib after Autologous Stem Cell Transplantation for Patients with Multiple Myeloma..” Biol Blood Marrow Transplant 23, no. 2 (February 2017): 262–68. https://doi.org/10.1016/j.bbmt.2016.11.010.
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    • Green, Michael M. B., Nelson Chao, Saurabh Chhabra, Kelly Corbet, Cristina Gasparetto, Ari Horwitz, Zhiguo Li, et al. “Plerixafor (a CXCR4 antagonist) following myeloablative allogeneic hematopoietic stem cell transplantation enhances hematopoietic recovery..” J Hematol Oncol 9, no. 1 (August 17, 2016). https://doi.org/10.1186/s13045-016-0301-2.
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    • Li, Zhiguo, and Kouros Owzar. “Fitting Cox Models with Doubly Censored Data Using Spline-Based Sieve Marginal Likelihood..” Scand Stat Theory Appl 43, no. 2 (June 2016): 476–86. https://doi.org/10.1111/sjos.12186.
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    • Yang, Yang, Jonathan C. Poe, Lisong Yang, Andrew Fedoriw, Siddhi Desai, Terry Magnuson, Zhiguo Li, et al. “Rad18 confers hematopoietic progenitor cell DNA damage tolerance independently of the Fanconi Anemia pathway in vivo..” Nucleic Acids Res 44, no. 9 (May 19, 2016): 4174–88. https://doi.org/10.1093/nar/gkw072.
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    • Wang, Yu, Zheng Zhang, Dong Ji, Guo-Feng Chen, Xia Feng, Lu-Lu Gong, Jian Guo, et al. “Regulation of T cell function by microRNA-720..” Sci Rep 5 (July 22, 2015). https://doi.org/10.1038/srep12159.
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    • Tuchman, Sascha A., Wendi A. Bacon, Li-Wen Huang, Gwynn Long, David Rizzieri, Mitchell Horwitz, John P. Chute, et al. “Cyclophosphamide-based hematopoietic stem cell mobilization before autologous stem cell transplantation in newly diagnosed multiple myeloma..” J Clin Apher 30, no. 3 (June 2015): 176–82. https://doi.org/10.1002/jca.21360.
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    • Detweiler, Claire, Michael Shealy, Anthony Sung, Daniel Wild, Martin Poleski, Bryan Balmadrid, Constance Cirrincione, Zhiguo Li, Keith Sullivan, and Diana Cardona. “Utilization of the NIH Consensus Guidelines Improves the Diagnostic Accuracy of Gastrointestinal Graft Versus Host Disease: A Five-Year Retrospective Study.” Modern Pathology 28 (February 1, 2015): 157A-157A.
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    • Li, Zhiguo, Marcia Valenstein, Paul Pfeiffer, and Dara Ganoczy. “A global logrank test for adaptive treatment strategies based on observational studies..” Stat Med 33, no. 5 (February 28, 2014): 760–71. https://doi.org/10.1002/sim.5987.
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    • Kanda, Junya, Gwynn D. Long, Cristina Gasparetto, Mitchell E. Horwitz, Keith M. Sullivan, John P. Chute, Ashley Morris, et al. “Reduced-intensity allogeneic transplantation using alemtuzumab from HLA-matched related, unrelated, or haploidentical related donors for patients with hematologic malignancies..” Biol Blood Marrow Transplant 20, no. 2 (February 2014): 257–63. https://doi.org/10.1016/j.bbmt.2013.11.010.
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    • Xiao, Bin, Yu Wang, Wei Li, Megan Baker, Jian Guo, Kelly Corbet, Ephraim L. Tsalik, et al. “Plasma microRNA signature as a noninvasive biomarker for acute graft-versus-host disease..” Blood 122, no. 19 (November 7, 2013): 3365–75. https://doi.org/10.1182/blood-2013-06-510586.
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    • Lunsford, Keri E., Brandon J. Baird, Gregory D. Sempowski, Diana M. Cardona, Zhiguo Li, Kent J. Weinhold, Debra L. Sudan, and Todd V. Brennan. “Upregulation of IL-1β, IL-6, and CCL-2 by a novel mouse model of pancreatic ischemia-reperfusion injury..” Transplantation 95, no. 8 (April 27, 2013): 1000–1007. https://doi.org/10.1097/TP.0b013e318286483a.
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    • Zhou, Dunhua, Divino Deoliveira, Yubin Kang, Seung S. Choi, Zhiguo Li, Nelson J. Chao, and Benny J. Chen. “Insulin-like growth factor 1 mitigates hematopoietic toxicity after lethal total body irradiation..” Int J Radiat Oncol Biol Phys 85, no. 4 (March 15, 2013): 1141–48. https://doi.org/10.1016/j.ijrobp.2012.08.014.
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    • Morris, Tod A., Carlos M. DeCastro, Louis F. Diehl, Jon P. Gockerman, Anand S. Lagoo, Zhiguo Li, Joseph O. Moore, David A. Rizzieri, and Arati V. Rao. “Re-induction therapy decisions based on day 14 bone marrow biopsy in acute myeloid leukemia..” Leuk Res 37, no. 1 (January 2013): 28–31. https://doi.org/10.1016/j.leukres.2012.09.016.
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    • Brennan, Todd V., Liwen Lin, Xiaopei Huang, Diana M. Cardona, Zhiguo Li, Keith Dredge, Nelson J. Chao, and Yiping Yang. “Heparan sulfate, an endogenous TLR4 agonist, promotes acute GVHD after allogeneic stem cell transplantation..” Blood 120, no. 14 (October 4, 2012): 2899–2908. https://doi.org/10.1182/blood-2011-07-368720.
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    • Owzar, Kouros, Zhiguo Li, Nancy Cox, and Sin-Ho Jung. “Power and sample size calculations for SNP association studies with censored time-to-event outcomes..” Genet Epidemiol 36, no. 6 (September 2012): 538–48. https://doi.org/10.1002/gepi.21645.
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    • Kanda, J., M. E. Horwitz, G. D. Long, C. Gasparetto, K. M. Sullivan, J. P. Chute, A. Morris, et al. “Outcomes of a 1-day nonmyeloablative salvage regimen for patients with primary graft failure after allogeneic hematopoietic cell transplantation..” Bone Marrow Transplant 47, no. 5 (May 2012): 700–705. https://doi.org/10.1038/bmt.2011.158.
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    • Lanasa, Mark C., Patricia H. Davis, Michael Datto, Zhiguo Li, Jon P. Gockerman, Joseph O. Moore, Carlos M. DeCastro, et al. “Phase II study of cenersen, an antisense inhibitor of p53, in combination with fludarabine, cyclophosphamide and rituximab for high-risk chronic lymphocytic leukemia..” Leuk Lymphoma 53, no. 2 (February 2012): 218–24. https://doi.org/10.3109/10428194.2011.610012.
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    • Li, Z., and B. Nan. “Relative risk regression for current status data in case-cohort studies.” Canadian Journal of Statistics 39, no. 4 (December 1, 2011): 557–77. https://doi.org/10.1002/cjs.10111.
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    • Li, Zhiguo, Paul N. Pfeiffer, Katherine J. Hoggatt, Kara Zivin, Karen Downing, Dara Ganoczy, and Marcia Valenstein. “Emergent anxiety after antidepressant initiation: a retrospective cohort study of Veterans Affairs Health System patients with depression..” Clin Ther 33, no. 12 (December 2011): 1985-1992.e1. https://doi.org/10.1016/j.clinthera.2011.11.010.
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    • Li, Zhiguo, and Susan A. Murphy. “Sample size formulae for two-stage randomized trials with survival outcomes..” Biometrika 98, no. 3 (September 2011): 503–18. https://doi.org/10.1093/biomet/asr019.
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    • Klymenko, Sergiy V., David A. Belyi, Joel R. Ross, Kouros Owzar, Chen Jiang, Zhiguo Li, Janna N Minchenko, Aleksandr N Kovalenko, Volodymyr G. Bebeshko, and Nelson J Chao. “Hematopoietic cell infusion for the treatment of nuclear disaster victims: new data from the Chernobyl accident..” Int J Radiat Biol 87, no. 8 (August 2011): 846–50. https://doi.org/10.3109/09553002.2011.560995.
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    • Rizzieri, David A., Christopher Crout, Robert Storms, Jared Golob, Gwynn D. Long, Cristina Gasparetto, Keith M. Sullivan, et al. “Feasibility of low-dose interleukin-2 therapy following T-cell-depleted nonmyeloablative allogeneic hematopoietic stem cell transplantation from HLA-matched or -mismatched family member donors..” Cancer Invest 29, no. 1 (January 2011): 56–61. https://doi.org/10.3109/07357907.2010.535055.
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    • Li, Z., J. M. G. Taylor, and B. Nan. “Construction of confidence intervals and regions for ordered binomial probabilities.” American Statistician 64, no. 4 (November 1, 2010): 291–98. https://doi.org/10.1198/tast.2010.09096.
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    • Li, Zhiguo, Peter Gilbert, and Bin Nan. “Weighted likelihood method for grouped survival data in case-cohort studies with application to HIV vaccine trials..” Biometrics 64, no. 4 (December 2008): 1247–55. https://doi.org/10.1111/j.1541-0420.2008.00998.x.
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    • Taylor, Jeremy M. G., Lu Wang, and Zhiguo Li. “Analysis on binary responses with ordered covariates and missing data..” Stat Med 26, no. 18 (August 15, 2007): 3443–58. https://doi.org/10.1002/sim.2815.
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    • Taylor, Jeremy M. G., Thomas M. Braun, and Zhiguo Li. “Comparing an experimental agent to a standard agent: relative merits of a one-arm or randomized two-arm Phase II design..” Clin Trials 3, no. 4 (2006): 335–48. https://doi.org/10.1177/1740774506070654.
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  • Conference Papers

    • Sivaraj, Dharshan, Michael M. Green, Yubin Kang, David Rizzieri, Louis F. Diehl, Anne W. Beaven, Zhiguo Li, et al. “Phase I/II dose expansion of a trial investigating bendamustine and pomalidomide with dexamethasone (BPd) in patients with relapsed/refractory multiple myeloma..” In Journal of Clinical Oncology, 35:8008–8008. American Society of Clinical Oncology (ASCO), 2017. https://doi.org/10.1200/jco.2017.35.15_suppl.8008.
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    • Jia, Wei, Jonathan C. Poe, Hsuan Su, Glenn K. Matsushima, Jeffrey Rathmell, Kazuhiro Imai, Nancy J. Reyes, et al. “Recipient-Derived BAFF and Alloantigen Synergistically Activate B Cells in Murine Chronic Gvhd.” In Blood, Vol. 128. AMER SOC HEMATOLOGY, 2016.
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    • Poe, Jonathan C., Wei Jia, Hsuan Su, Zhiguo Li, Frances T. Hakim, Steven Z. Pavletic, Jeremy J. Rose, et al. “All-Trans Retinoic Acid (ATRA) Targets IRF4 Deficient, NOTCH2-Activated B Cells from Chronic Gvhd Patients.” In Blood, Vol. 128. AMER SOC HEMATOLOGY, 2016.
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    • Poe, Jonathan C., Wei Jia, Zhiguo Li, Frances T. Hakim, Steven Z. Pavletic, Jeremy J. Rose, David A. Rizzieri, et al. “Targeting the Human Notch 2-BCR Axis: A Driver of B-Cell Hyper-Responsiveness in Active Chronic Graft-Versus Host Disease (cGVHD).” In Blood, Vol. 126. AMER SOC HEMATOLOGY, 2015.
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    • Detweiler, Claire, Michael Shealy, Anthony Sung, Daniel Wild, Martin Poleski, Bryan Balmadrid, Constance Cirrincione, Zhiguo Li, Keith Sullivan, and Diana Cardona. “Utilization of the NIH Consensus Guidelines Improves the Diagnostic Accuracy of Gastrointestinal Graft Versus Host Disease: A Five-Year Retrospective Study.” In Laboratory Investigation, 95:157A-157A. NATURE PUBLISHING GROUP, 2015.
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    • Green, Michael M. B., Mitchell E. Horwitz, Yubin Kang, Nelson J. Chao, Gwynn D. Long, David Rizzieri, Cristina Gasparetto, et al. “Administration of Plerixafor (a CXCR4 antagonist) Following Myeloablative Allogeneic Hematopoietic Stem Cell Transplantation Enhances Platelet Recovery in a Phase I/II Trial.” In Biology of Blood and Marrow Transplantation, 21:S31–32. Elsevier BV, 2015. https://doi.org/10.1016/j.bbmt.2014.11.024.
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    • Sung, Anthony D., Diana Cardona, Krista Rowe, Hossein Mehdikhani, Claire Detweiler, Michael Shealy, Daniel Wild, et al. “Late Gastrointestinal Complications of Allogeneic Hematopoietic Stem Cell Transplantation.” In Biology of Blood and Marrow Transplantation, 21:S314–15. Elsevier BV, 2015. https://doi.org/10.1016/j.bbmt.2014.11.500.
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    • Beaven, Anne W., David A. Rizzieri, Zachary Powell, Zhiguo Li, Peggy Alton, Julie Warzecho, Louis F. Diehl, Joseph O. Moore, Carlos Manuel de Castro, and Jon P. Gockerman. “High Complete Response Rates with Dose Dense/Dose Intense Chemotherapy Plus Radioimmunotherapy in High Risk Diffuse Large B Cell and Mantle Cell Lymphoma.” In Blood, 118:1152–1152. AMER SOC HEMATOLOGY, 2011.
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    • Gasparetto, Cristina, Wendi A. Bacon, Phuong Doan, David A. Rizzieri, Mitchell E. Horwitz, John P. Chute, Keith M. Sullivan, et al. “High Dose BCNU/Melphalan Preparative Regimen Doubles Event Free Survival of Myeloma Patients Undergoing Autologous Transplantation.” In Blood, 118:879–879. AMER SOC HEMATOLOGY, 2011.
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    • Kanda, Junya, Gwynn D. Long, Cristina Gasparetto, Mitchell E. Horwitz, Keith M. Sullivan, John P. Chute, Ashley Morris, Zhiguo Li, Nelson J. Chao, and David A. Rizzieri. “Prospective, Biological Randomized Study of T-Cell Depleted Nonmyeloablative Allogeneic Transplantation From HLA-Matched Related, Unrelated or Haploidentical Donors for Patients with Hematologic Malignancies..” In Blood, 116:1456–57. AMER SOC HEMATOLOGY, 2010.
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• Teaching & Mentoring
• 

  Recent Courses

  • BIOSTAT 911: Advanced Inferential Techniques and Theory 2019
  • BIOSTAT 901: Advanced Inferential Techniques and Theory 2018

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