Zhiguo Li | Scholars@Duke

Zhiguo Li
Associate Professor of Biostatistics & Bioinformatics

survival analysis, dynamic treatment regimes, clinical trials

Current Appointments & Affiliations

Associate Professor of Biostatistics & Bioinformatics, Biostatistics & Bioinformatics, Basic Science Departments 2015
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2010

Contact Information

2424 Erwin Road Ste 1102, 11086 Hock Plaza, Durham, NC 27705
Duke Box 2721, Durham, NC 27710
(919) 668-7805

Background
Education, Training, & Certifications
- Ph.D., University of Michigan at Ann Arbor 2008
Research
Selected Grants
- Mitigators of Radiation-Induced Endovascular Injury: Targeting Tie2 and Thrombocytopenia awarded by National Institutes of Health 2017 - 2022
- Effects of PPAR agonists on response to immunomodulatory agents in patients with multiple myeloma awarded by National Institutes of Health 2019 - 2020
- Breaking B-Cell Tolerance to Produce Antibodies that Eradicate Leukemias and Lymphomas awarded by Department of Defense 2018 - 2020
- Pathological B Cells: Novel Strategies to Prevent and Treat Chronic GVHD awarded by National Institutes of Health 2015 - 2020
- The Notch2-BCR Axis: Targeting Drivers of B cell Fate in Chronic GVHD awarded by Leukemia & Lymphoma Society 2015 - 2019
- Methods for Discovery and Analysis of Dynamic Treatment Regimes awarded by University of North Carolina - Chapel Hill 2015 - 2019
- Statistical/Computational Methods for Pharmacogenomics and Individualized Therapy awarded by University of North Carolina - Chapel Hill 2015 - 2019
- Validation of a microRNA signature for the prediction, diagnosis and prognosis of acute graft-versus-host disease awarded by Blood and Marrow Transplant Clinical Trials Network 2015
- Plasma microRNAs as non-invasive biomarker for acute graft-versus-host diseases awarded by The Biomarker Factory 2014 - 2015
- Mayo Alliance Foundation Funds awarded by Mayo Foundation 2012 - 2014
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Li, Z, Wang, X, Wu, Y, and Owzar, K. "Sample size calculation for studies with grouped survival data." Statistics in Medicine 37, no. 27 (November 2018): 3904-3917. Full Text Open Access Copy
  - Heyman, B, Rizzieri, D, Adams, DJ, De Castro, C, Diehl, L, Li, Z, Moore, J, and Beaven, A. "Phase I Study of the Combination of Bendamustine, Rituximab, and Pixantrone in Patients With Relapsed/Refractory B-cell Non-Hodgkin Lymphoma." Clinical Lymphoma, Myeloma & Leukemia 18, no. 10 (October 2018): 679-686. Full Text
  - Sung, AD, Hassan, S, Cardona, DM, Wild, D, Nichols, KR, Mehdikhani, H, Balmadrid, B, Detweiler, CJ, Shealy, M, Cirrincione, C, Li, Z, Poleski, M, Dalton, TE, Siamakpour-Reihani, S, Chao, NJ, and Sullivan, KM. "Late Gastrointestinal Complications of Allogeneic Hematopoietic Stem Cell Transplantation in Adults." Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation 24, no. 4 (April 2018): 734-740. Full Text
  - Sibley, A, Li, Z, Jiang, Y, Li, Y-J, Chan, C, Allen, A, and Owzar, K. "Facilitating the Calculation of the Efficient Score Using Symbolic Computing." The American Statistician 72, no. 2 (January 2018): 199-205. Full Text
  - Sivaraj, D, Bacon, W, Long, GD, Rizzieri, DA, Horwitz, ME, Sullivan, KM, Kang, Y, Li, Z, Chao, NJ, and Gasparetto, C. "High-dose BCNU/Melphalan conditioning regimen before autologous stem cell transplantation in newly diagnosed multiple myeloma." Bone Marrow Transplantation 53, no. 1 (January 2018): 34-38. Full Text
  - Tuchman, SA, Moore, JO, DeCastro, CD, Li, Z, Sellars, E, Kang, Y, Long, G, and Gasparetto, CG. "Phase II study of dose-attenuated bortezomib, cyclophosphamide and dexamethasone ("VCD-Lite") in very old or otherwise toxicity-vulnerable adults with newly diagnosed multiple myeloma." Journal of geriatric oncology 8, no. 3 (May 2017): 165-169. Full Text
  - Li, Z. "Comparison of adaptive treatment strategies based on longitudinal outcomes in sequential multiple assignment randomized trials." Statistics in medicine 36, no. 3 (February 2017): 403-415. Full Text
  - Sivaraj, D, Green, MM, Li, Z, Sung, AD, Sarantopoulos, S, Kang, Y, Long, GD, Horwitz, ME, Lopez, RD, Sullivan, KM, Rizzieri, DA, Chao, NJ, and Gasparetto, C. "Outcomes of Maintenance Therapy with Bortezomib after Autologous Stem Cell Transplantation for Patients with Multiple Myeloma." Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation 23, no. 2 (February 2017): 262-268. Full Text
  - Green, MMB, Chao, N, Chhabra, S, Corbet, K, Gasparetto, C, Horwitz, A, Li, Z, Venkata, JK, Long, G, Mims, A, Rizzieri, D, Sarantopoulos, S, Stuart, R, Sung, AD, Sullivan, KM, Costa, L, Horwitz, M, and Kang, Y. "Plerixafor (a CXCR4 antagonist) following myeloablative allogeneic hematopoietic stem cell transplantation enhances hematopoietic recovery." Journal of Hematology & Oncology 9, no. 1 (August 17, 2016): 71-null. Full Text Open Access Copy
  - Yang, Y, Poe, JC, Yang, L, Fedoriw, A, Desai, S, Magnuson, T, Li, Z, Fedoriw, Y, Araki, K, Gao, Y, Tateishi, S, Sarantopoulos, S, and Vaziri, C. "Rad18 confers hematopoietic progenitor cell DNA damage tolerance independently of the Fanconi Anemia pathway in vivo." Nucleic Acids Research 44, no. 9 (May 2016): 4174-4188. Full Text Open Access Copy
  - Li, Z, and Owzar, K. "Fitting Cox Models with Doubly Censored Data Using Spline-Based Sieve Marginal Likelihood." Scandinavian Journal of Statistics 43, no. 2 (2016): 476-486. Full Text
  - Wang, Y, Zhang, Z, Ji, D, Chen, G-F, Feng, X, Gong, L-L, Guo, J, Li, Z-W, Chen, C-F, Zhao, B-B, Li, Z-G, Li, Q-J, Yan, H-P, Sempowski, G, Wang, F-S, and He, Y-W. "Regulation of T cell function by microRNA-720." Scientific Reports 5 (July 22, 2015): 12159-null. Full Text
  - Tuchman, SA, Bacon, WA, Huang, L-W, Long, G, Rizzieri, D, Horwitz, M, Chute, JP, Sullivan, K, Morris Engemann, A, Yopp, A, Li, Z, Corbet, K, Chao, N, and Gasparetto, C. "Cyclophosphamide-based hematopoietic stem cell mobilization before autologous stem cell transplantation in newly diagnosed multiple myeloma." Journal of Clinical Apheresis 30, no. 3 (June 2015): 176-182. Full Text
  - Detweiler, C, Shealy, M, Sung, A, Wild, D, Poleski, M, Balmadrid, B, Cirrincione, C, Li, Z, Sullivan, K, and Cardona, D. "Utilization of the NIH Consensus Guidelines Improves the Diagnostic Accuracy of Gastrointestinal Graft Versus Host Disease: A Five-Year Retrospective Study." MODERN PATHOLOGY 28 (February 2015): 157A-157A. Link to Item
  - Li, Z, Valenstein, M, Pfeiffer, P, and Ganoczy, D. "A global logrank test for adaptive treatment strategies based on observational studies." Statistics in Medicine 33, no. 5 (February 28, 2014): 760-771. Full Text
  - Kanda, J, Long, GD, Gasparetto, C, Horwitz, ME, Sullivan, KM, Chute, JP, Morris, A, Shafique, M, Li, Z, Chao, NJ, and Rizzieri, DA. "Reduced-intensity allogeneic transplantation using alemtuzumab from HLA-matched related, unrelated, or haploidentical related donors for patients with hematologic malignancies." Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation 20, no. 2 (February 2014): 257-263. Full Text
  - Li, Z, Valenstein, M, Pfeiffer, P, and Ganoczy, D. "A global logrank test for adaptive treatment strategies based on observational studies." Statistics in Medicine 33, no. 5 (February 2014): 760-771. Full Text
  - Xiao, B, Wang, Y, Li, W, Baker, M, Guo, J, Corbet, K, Tsalik, EL, Li, Q-J, Palmer, SM, Woods, CW, Li, Z, Chao, NJ, and He, Y-W. "Plasma microRNA signature as a noninvasive biomarker for acute graft-versus-host disease." Blood 122, no. 19 (November 7, 2013): 3365-3375. Full Text Link to Item
  - Zhou, D, Deoliveira, D, Kang, Y, Choi, SS, Li, Z, Chao, NJ, and Chen, BJ. "Insulin-like growth factor 1 mitigates hematopoietic toxicity after lethal total body irradiation." International Journal of Radiation Oncology, Biology, Physics 85, no. 4 (March 2013): 1141-1148. Full Text
  - Lunsford, KE, Baird, BJ, Sempowski, GD, Cardona, DM, Li, Z, Weinhold, KJ, Sudan, DL, and Brennan, TV. "Upregulation of IL-1β, IL-6, and CCL-2 by a novel mouse model of pancreatic ischemia-reperfusion injury." Transplantation 95, no. 8 (2013): 1000-1007. Full Text
  - Morris, TA, DeCastro, CM, Diehl, LF, Gockerman, JP, Lagoo, AS, Li, Z, Moore, JO, Rizzieri, DA, and Rao, AV. "Re-induction therapy decisions based on day 14 bone marrow biopsy in acute myeloid leukemia." Leuk Res 37, no. 1 (January 2013): 28-31. Full Text Link to Item
  - Brennan, TV, Lin, L, Huang, X, Cardona, DM, Li, Z, Dredge, K, Chao, NJ, and Yang, Y. "Heparan sulfate, an endogenous TLR4 agonist, promotes acute GVHD after allogeneic stem cell transplantation." Blood 120, no. 14 (October 4, 2012): 2899-2908. Full Text Link to Item
  - Owzar, K, Li, Z, Cox, N, and Jung, S-H. "Power and sample size calculations for SNP association studies with censored time-to-event outcomes." Genet Epidemiol 36, no. 6 (September 2012): 538-548. Full Text Link to Item
  - Kanda, J, Horwitz, ME, Long, GD, Gasparetto, C, Sullivan, KM, Chute, JP, Morris, A, Hennig, T, Li, Z, Chao, NJ, and Rizzieri, DA. "Outcomes of a 1-day nonmyeloablative salvage regimen for patients with primary graft failure after allogeneic hematopoietic cell transplantation." Bone Marrow Transplant 47, no. 5 (May 2012): 700-705. Full Text Link to Item
  - Lanasa, MC, Davis, PH, Datto, M, Li, Z, Gockerman, JP, Moore, JO, DeCastro, CM, Friedman, DR, Diehl, LF, Rehder, C, Cook, H, Daugherty, FJ, Matta, KMB, Weinberg, JB, and Rizzieri, D. "Phase II study of cenersen, an antisense inhibitor of p53, in combination with fludarabine, cyclophosphamide and rituximab for high-risk chronic lymphocytic leukemia." Leukemia & Lymphoma 53, no. 2 (February 2012): 218-224. Full Text
  - Li, Z, Pfeiffer, PN, Hoggatt, KJ, Zivin, K, Downing, K, Ganoczy, D, and Valenstein, M. "Emergent anxiety after antidepressant initiation: a retrospective cohort study of Veterans Affairs Health System patients with depression." Clinical Therapeutics 33, no. 12 (December 2011): 1985-1992.e1. Full Text
  - Li, Z, and Nan, B. "Relative risk regression for current status data in case-cohort studies." Canadian Journal of Statistics 39, no. 4 (December 1, 2011): 557-577. Full Text
  - Li, Z, and Murphy, SA. "Sample size formulae for two-stage randomized trials with survival outcomes." Biometrika 98, no. 3 (September 2011): 503-518. Full Text Link to Item
  - Klymenko, SV, Belyi, DA, Ross, JR, Owzar, K, Jiang, C, Li, Z, N Minchenko, J, N Kovalenko, A, Bebeshko, VG, and J Chao, N. "Hematopoietic cell infusion for the treatment of nuclear disaster victims: new data from the Chernobyl accident." Int J Radiat Biol 87, no. 8 (August 2011): 846-850. Full Text Link to Item
  - Rizzieri, DA, Crout, C, Storms, R, Golob, J, Long, GD, Gasparetto, C, Sullivan, KM, Horwitz, M, Chute, J, Lagoo, AS, Morris, A, Beaven, A, Yang, Y, Peterson, B, Li, Z, and Chao, NJ. "Feasibility of low-dose interleukin-2 therapy following T-cell-depleted nonmyeloablative allogeneic hematopoietic stem cell transplantation from HLA-matched or -mismatched family member donors." Cancer Invest 29, no. 1 (January 2011): 56-61. Full Text Link to Item
  - Li, Z, Taylor, JMG, and Nan, B. "Construction of confidence intervals and regions for ordered binomial probabilities." American Statistician 64, no. 4 (November 1, 2010): 291-298. Full Text
  - Li, Z, Gilbert, P, and Nan, B. "Weighted likelihood method for grouped survival data in case-cohort studies with application to HIV vaccine trials." Biometrics 64, no. 4 (2008): 1247-1255. Full Text
  - Taylor, JMG, Wang, L, and Li, Z. "Analysis on binary responses with ordered covariates and missing data." Statistics in Medicine 26, no. 18 (2007): 3443-3458. Full Text
  - Taylor, JMG, Braun, TM, and Li, Z. "Comparing an experimental agent to a standard agent: relative merits of a one-arm or randomized two-arm Phase II design." Clinical Trials (London, England) 3, no. 4 (January 2006): 335-348. Full Text
- Conference Papers
  - Sivaraj, D, Green, MM, Kang, Y, Rizzieri, D, Diehl, LF, Beaven, AW, Li, Z, Garrett, A, McIntyre, J, Long, GD, Chao, NJA, and Gasparetto, C. "Phase I/II dose expansion of a trial investigating bendamustine and pomalidomide with dexamethasone (BPd) in patients with relapsed/refractory multiple myeloma." : American Society of Clinical Oncology (ASCO), May 20, 2017. Full Text
  - Jia, W, Poe, JC, Su, H, Matsushima, GK, Rathmell, J, Imai, K, Reyes, NJ, Cardona, DM, Anand, S, Deoliveira, D, Li, Z, Saban, DR, Chen, BJ, Chao, NJ, and Sarantopoulos, S. "Recipient-Derived BAFF and Alloantigen Synergistically Activate B Cells in Murine Chronic Gvhd." December 2, 2016. Link to Item
  - Poe, JC, Jia, W, Su, H, Li, Z, Hakim, FT, Pavletic, SZ, Rose, JJ, Rizzieri, DA, Yang, Y, Chen, BJ, Anand, S, Ritz, J, Siebel, CW, Chao, NJ, Maillard, I, and Sarantopoulos, S. "All-Trans Retinoic Acid (ATRA) Targets IRF4 Deficient, NOTCH2-Activated B Cells from Chronic Gvhd Patients." 58th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH). San Diego, CA. December 3, 2016 - December 6, 2016.: AMER SOC HEMATOLOGY, December 2, 2016. Link to Item
  - Poe, JC, Jia, W, Li, Z, Hakim, FT, Pavletic, SZ, Rose, JJ, Rizzieri, DA, Yang, Y, Chen, BJ, Green, M, Anand, S, Siebel, CW, Maillard, I, Chao, NJ, and Sarantopoulos, S. "Targeting the Human Notch 2-BCR Axis: A Driver of B-Cell Hyper-Responsiveness in Active Chronic Graft-Versus Host Disease (cGVHD)." December 3, 2015. Link to Item
  - Detweiler, C, Shealy, M, Sung, A, Wild, D, Poleski, M, Balmadrid, B, Cirrincione, C, Li, Z, Sullivan, K, and Cardona, D. "Utilization of the NIH Consensus Guidelines Improves the Diagnostic Accuracy of Gastrointestinal Graft Versus Host Disease: A Five-Year Retrospective Study." February 2015. Link to Item
  - Green, MMB, Horwitz, ME, Kang, Y, Chao, NJ, Long, GD, Rizzieri, D, Gasparetto, C, Sung, AD, Sarantopoulos, S, Li, Z, Corbet, K, Riggan-Stuelke, E, Sullivan, K, Wilson, B, Chhabra, S, Costa, LV, Mims, A, and Stuart, R. "Administration of Plerixafor (a CXCR4 antagonist) Following Myeloablative Allogeneic Hematopoietic Stem Cell Transplantation Enhances Platelet Recovery in a Phase I/II Trial." : Elsevier BV, February 2015. Full Text
  - Sung, AD, Cardona, D, Rowe, K, Mehdikhani, H, Detweiler, C, Shealy, M, Wild, D, Poleski, M, Cirrincione, C, Li, Z, Chao, NJ, and Sullivan, K. "Late Gastrointestinal Complications of Allogeneic Hematopoietic Stem Cell Transplantation." February 2015. Full Text
  - Beaven, AW, Rizzieri, DA, Powell, Z, Li, Z, Alton, P, Warzecho, J, Diehl, LF, Moore, JO, III, DCCM, and Gockerman, JP. "High Complete Response Rates with Dose Dense/Dose Intense Chemotherapy Plus Radioimmunotherapy in High Risk Diffuse Large B Cell and Mantle Cell Lymphoma." November 18, 2011. Link to Item
  - Gasparetto, C, Bacon, WA, Doan, P, Rizzieri, DA, Horwitz, ME, Chute, JP, Sullivan, KM, Yopp, A, Li, Z, Chao, NJ, and Long, GD. "High Dose BCNU/Melphalan Preparative Regimen Doubles Event Free Survival of Myeloma Patients Undergoing Autologous Transplantation." November 18, 2011. Link to Item
  - Kanda, J, Long, GD, Gasparetto, C, Horwitz, ME, Sullivan, KM, Chute, JP, Morris, A, Li, Z, Chao, NJ, and Rizzieri, DA. "Prospective, Biological Randomized Study of T-Cell Depleted Nonmyeloablative Allogeneic Transplantation From HLA-Matched Related, Unrelated or Haploidentical Donors for Patients with Hematologic Malignancies." November 19, 2010. Link to Item
Teaching & Mentoring
Recent Courses
- BIOSTAT 911: Advanced Inferential Techniques and Theory 2019
- BIOSTAT 901: Advanced Inferential Techniques and Theory 2018

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Education, Training, & Certifications

Selected Grants

Selected Publications

Academic Articles

Conference Papers

Recent Courses