Skip to main content
Journal cover image

Potential antigenic explanation for atypical H1N1 infections among middle-aged adults during the 2013-2014 influenza season.

Publication ,  Journal Article
Linderman, SL; Chambers, BS; Zost, SJ; Parkhouse, K; Li, Y; Herrmann, C; Ellebedy, AH; Carter, DM; Andrews, SF; Zheng, N-Y; Huang, M; Huang, Y ...
Published in: Proc Natl Acad Sci U S A
November 4, 2014

Influenza viruses typically cause the most severe disease in children and elderly individuals. However, H1N1 viruses disproportionately affected middle-aged adults during the 2013-2014 influenza season. Although H1N1 viruses recently acquired several mutations in the hemagglutinin (HA) glycoprotein, classic serological tests used by surveillance laboratories indicate that these mutations do not change antigenic properties of the virus. Here, we show that one of these mutations is located in a region of HA targeted by antibodies elicited in many middle-aged adults. We find that over 42% of individuals born between 1965 and 1979 possess antibodies that recognize this region of HA. Our findings offer a possible antigenic explanation of why middle-aged adults were highly susceptible to H1N1 viruses during the 2013-2014 influenza season. Our data further suggest that a drifted H1N1 strain should be included in future influenza vaccines to potentially reduce morbidity and mortality in this age group.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Proc Natl Acad Sci U S A

DOI

EISSN

1091-6490

Publication Date

November 4, 2014

Volume

111

Issue

44

Start / End Page

15798 / 15803

Location

United States

Related Subject Headings

  • Mutation
  • Middle Aged
  • Mice, Inbred BALB C
  • Mice
  • Male
  • Influenza, Human
  • Influenza Vaccines
  • Influenza A Virus, H1N1 Subtype
  • Humans
  • Hemagglutinin Glycoproteins, Influenza Virus
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Linderman, S. L., Chambers, B. S., Zost, S. J., Parkhouse, K., Li, Y., Herrmann, C., … Hensley, S. E. (2014). Potential antigenic explanation for atypical H1N1 infections among middle-aged adults during the 2013-2014 influenza season. Proc Natl Acad Sci U S A, 111(44), 15798–15803. https://doi.org/10.1073/pnas.1409171111
Linderman, Susanne L., Benjamin S. Chambers, Seth J. Zost, Kaela Parkhouse, Yang Li, Christin Herrmann, Ali H. Ellebedy, et al. “Potential antigenic explanation for atypical H1N1 infections among middle-aged adults during the 2013-2014 influenza season.Proc Natl Acad Sci U S A 111, no. 44 (November 4, 2014): 15798–803. https://doi.org/10.1073/pnas.1409171111.
Linderman SL, Chambers BS, Zost SJ, Parkhouse K, Li Y, Herrmann C, et al. Potential antigenic explanation for atypical H1N1 infections among middle-aged adults during the 2013-2014 influenza season. Proc Natl Acad Sci U S A. 2014 Nov 4;111(44):15798–803.
Linderman, Susanne L., et al. “Potential antigenic explanation for atypical H1N1 infections among middle-aged adults during the 2013-2014 influenza season.Proc Natl Acad Sci U S A, vol. 111, no. 44, Nov. 2014, pp. 15798–803. Pubmed, doi:10.1073/pnas.1409171111.
Linderman SL, Chambers BS, Zost SJ, Parkhouse K, Li Y, Herrmann C, Ellebedy AH, Carter DM, Andrews SF, Zheng N-Y, Huang M, Huang Y, Strauss D, Shaz BH, Hodinka RL, Reyes-Terán G, Ross TM, Wilson PC, Ahmed R, Bloom JD, Hensley SE. Potential antigenic explanation for atypical H1N1 infections among middle-aged adults during the 2013-2014 influenza season. Proc Natl Acad Sci U S A. 2014 Nov 4;111(44):15798–15803.
Journal cover image

Published In

Proc Natl Acad Sci U S A

DOI

EISSN

1091-6490

Publication Date

November 4, 2014

Volume

111

Issue

44

Start / End Page

15798 / 15803

Location

United States

Related Subject Headings

  • Mutation
  • Middle Aged
  • Mice, Inbred BALB C
  • Mice
  • Male
  • Influenza, Human
  • Influenza Vaccines
  • Influenza A Virus, H1N1 Subtype
  • Humans
  • Hemagglutinin Glycoproteins, Influenza Virus