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Recent trends in protein and peptide-based biomaterials for advanced drug delivery.

Publication ,  Journal Article
Varanko, A; Saha, S; Chilkoti, A
Published in: Advanced drug delivery reviews
January 2020

Engineering protein and peptide-based materials for drug delivery applications has gained momentum due to their biochemical and biophysical properties over synthetic materials, including biocompatibility, ease of synthesis and purification, tunability, scalability, and lack of toxicity. These biomolecules have been used to develop a host of drug delivery platforms, such as peptide- and protein-drug conjugates, injectable particles, and drug depots to deliver small molecule drugs, therapeutic proteins, and nucleic acids. In this review, we discuss progress in engineering the architecture and biological functions of peptide-based biomaterials -naturally derived, chemically synthesized and recombinant- with a focus on the molecular features that modulate their structure-function relationships for drug delivery.

Duke Scholars

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Published In

Advanced drug delivery reviews

DOI

EISSN

1872-8294

ISSN

0169-409X

Publication Date

January 2020

Volume

156

Start / End Page

133 / 187

Related Subject Headings

  • Translational Research, Biomedical
  • Proteins
  • Pharmacology & Pharmacy
  • Peptides
  • Humans
  • Drug Delivery Systems
  • Biocompatible Materials
  • Animals
  • 3214 Pharmacology and pharmaceutical sciences
  • 1115 Pharmacology and Pharmaceutical Sciences
 

Citation

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Varanko, A., Saha, S., & Chilkoti, A. (2020). Recent trends in protein and peptide-based biomaterials for advanced drug delivery. Advanced Drug Delivery Reviews, 156, 133–187. https://doi.org/10.1016/j.addr.2020.08.008
Varanko, Anastasia, Soumen Saha, and Ashutosh Chilkoti. “Recent trends in protein and peptide-based biomaterials for advanced drug delivery.Advanced Drug Delivery Reviews 156 (January 2020): 133–87. https://doi.org/10.1016/j.addr.2020.08.008.
Varanko A, Saha S, Chilkoti A. Recent trends in protein and peptide-based biomaterials for advanced drug delivery. Advanced drug delivery reviews. 2020 Jan;156:133–87.
Varanko, Anastasia, et al. “Recent trends in protein and peptide-based biomaterials for advanced drug delivery.Advanced Drug Delivery Reviews, vol. 156, Jan. 2020, pp. 133–87. Epmc, doi:10.1016/j.addr.2020.08.008.
Varanko A, Saha S, Chilkoti A. Recent trends in protein and peptide-based biomaterials for advanced drug delivery. Advanced drug delivery reviews. 2020 Jan;156:133–187.
Journal cover image

Published In

Advanced drug delivery reviews

DOI

EISSN

1872-8294

ISSN

0169-409X

Publication Date

January 2020

Volume

156

Start / End Page

133 / 187

Related Subject Headings

  • Translational Research, Biomedical
  • Proteins
  • Pharmacology & Pharmacy
  • Peptides
  • Humans
  • Drug Delivery Systems
  • Biocompatible Materials
  • Animals
  • 3214 Pharmacology and pharmaceutical sciences
  • 1115 Pharmacology and Pharmaceutical Sciences