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An Open Resource for Non-human Primate Optogenetics.

Publication ,  Journal Article
Tremblay, S; Acker, L; Afraz, A; Albaugh, DL; Amita, H; Andrei, AR; Angelucci, A; Aschner, A; Balan, PF; Basso, MA; Benvenuti, G; Bohlen, MO ...
Published in: Neuron
December 23, 2020

Optogenetics has revolutionized neuroscience in small laboratory animals, but its effect on animal models more closely related to humans, such as non-human primates (NHPs), has been mixed. To make evidence-based decisions in primate optogenetics, the scientific community would benefit from a centralized database listing all attempts, successful and unsuccessful, of using optogenetics in the primate brain. We contacted members of the community to ask for their contributions to an open science initiative. As of this writing, 45 laboratories around the world contributed more than 1,000 injection experiments, including precise details regarding their methods and outcomes. Of those entries, more than half had not been published. The resource is free for everyone to consult and contribute to on the Open Science Framework website. Here we review some of the insights from this initial release of the database and discuss methodological considerations to improve the success of optogenetic experiments in NHPs.

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Published In

Neuron

DOI

EISSN

1097-4199

Publication Date

December 23, 2020

Volume

108

Issue

6

Start / End Page

1075 / 1090.e6

Location

United States

Related Subject Headings

  • Primates
  • Optogenetics
  • Neurosciences
  • Neurons
  • Neurology & Neurosurgery
  • Brain
  • Animals
  • 5202 Biological psychology
  • 3209 Neurosciences
  • 1702 Cognitive Sciences
 

Citation

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Tremblay, S., Acker, L., Afraz, A., Albaugh, D. L., Amita, H., Andrei, A. R., … Platt, M. L. (2020). An Open Resource for Non-human Primate Optogenetics. Neuron, 108(6), 1075-1090.e6. https://doi.org/10.1016/j.neuron.2020.09.027
Tremblay, Sébastien, Leah Acker, Arash Afraz, Daniel L. Albaugh, Hidetoshi Amita, Ariana R. Andrei, Alessandra Angelucci, et al. “An Open Resource for Non-human Primate Optogenetics.Neuron 108, no. 6 (December 23, 2020): 1075-1090.e6. https://doi.org/10.1016/j.neuron.2020.09.027.
Tremblay S, Acker L, Afraz A, Albaugh DL, Amita H, Andrei AR, et al. An Open Resource for Non-human Primate Optogenetics. Neuron. 2020 Dec 23;108(6):1075-1090.e6.
Tremblay, Sébastien, et al. “An Open Resource for Non-human Primate Optogenetics.Neuron, vol. 108, no. 6, Dec. 2020, pp. 1075-1090.e6. Pubmed, doi:10.1016/j.neuron.2020.09.027.
Tremblay S, Acker L, Afraz A, Albaugh DL, Amita H, Andrei AR, Angelucci A, Aschner A, Balan PF, Basso MA, Benvenuti G, Bohlen MO, Caiola MJ, Calcedo R, Cavanaugh J, Chen Y, Chen S, Chernov MM, Clark AM, Dai J, Debes SR, Deisseroth K, Desimone R, Dragoi V, Egger SW, Eldridge MAG, El-Nahal HG, Fabbrini F, Federer F, Fetsch CR, Fortuna MG, Friedman RM, Fujii N, Gail A, Galvan A, Ghosh S, Gieselmann MA, Gulli RA, Hikosaka O, Hosseini EA, Hu X, Hüer J, Inoue K-I, Janz R, Jazayeri M, Jiang R, Ju N, Kar K, Klein C, Kohn A, Komatsu M, Maeda K, Martinez-Trujillo JC, Matsumoto M, Maunsell JHR, Mendoza-Halliday D, Monosov IE, Muers RS, Nurminen L, Ortiz-Rios M, O’Shea DJ, Palfi S, Petkov CI, Pojoga S, Rajalingham R, Ramakrishnan C, Remington ED, Revsine C, Roe AW, Sabes PN, Saunders RC, Scherberger H, Schmid MC, Schultz W, Seidemann E, Senova Y-S, Shadlen MN, Sheinberg DL, Siu C, Smith Y, Solomon SS, Sommer MA, Spudich JL, Stauffer WR, Takada M, Tang S, Thiele A, Treue S, Vanduffel W, Vogels R, Whitmire MP, Wichmann T, Wurtz RH, Xu H, Yazdan-Shahmorad A, Shenoy KV, DiCarlo JJ, Platt ML. An Open Resource for Non-human Primate Optogenetics. Neuron. 2020 Dec 23;108(6):1075-1090.e6.
Journal cover image

Published In

Neuron

DOI

EISSN

1097-4199

Publication Date

December 23, 2020

Volume

108

Issue

6

Start / End Page

1075 / 1090.e6

Location

United States

Related Subject Headings

  • Primates
  • Optogenetics
  • Neurosciences
  • Neurons
  • Neurology & Neurosurgery
  • Brain
  • Animals
  • 5202 Biological psychology
  • 3209 Neurosciences
  • 1702 Cognitive Sciences