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Four-Point Bending Testing for Mechanical Assessment of Mouse Bone Structural Properties.

Publication ,  Journal Article
Cutcliffe, HC; DeFrate, LE
Published in: Methods Mol Biol
2021

One of the primary functions of bone is to support the skeleton by withstanding load. In the diseased state, bone's ability to perform this function is altered. Quantification of the features of bone that support its functional behavior, and how they may change with disease, is accomplished through mechanical testing. As such, mechanical testing is a useful tool for scientists studying orthopedic-related diseases. Furthermore, a common animal model used to investigate disease and its treatment is the mouse. Therefore, in this chapter we (1) describe central concepts of mechanical testing, (2) describe factors that influence the mechanical behavior of bone, and (3) describe the application of a widely used mechanical testing technique, four-point bending, to the mouse bone for characterization of its structural properties.

Duke Scholars

Published In

Methods Mol Biol

DOI

EISSN

1940-6029

Publication Date

2021

Volume

2230

Start / End Page

199 / 215

Location

United States

Related Subject Headings

  • Weight-Bearing
  • Stress, Mechanical
  • Skull
  • Mice
  • Humans
  • Disease Models, Animal
  • Developmental Biology
  • Bone and Bones
  • Biomechanical Phenomena
  • Animals
 

Citation

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Chicago
ICMJE
MLA
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Cutcliffe, H. C., & DeFrate, L. E. (2021). Four-Point Bending Testing for Mechanical Assessment of Mouse Bone Structural Properties. Methods Mol Biol, 2230, 199–215. https://doi.org/10.1007/978-1-0716-1028-2_12
Cutcliffe, Hattie C., and Louis E. DeFrate. “Four-Point Bending Testing for Mechanical Assessment of Mouse Bone Structural Properties.Methods Mol Biol 2230 (2021): 199–215. https://doi.org/10.1007/978-1-0716-1028-2_12.
Cutcliffe HC, DeFrate LE. Four-Point Bending Testing for Mechanical Assessment of Mouse Bone Structural Properties. Methods Mol Biol. 2021;2230:199–215.
Cutcliffe, Hattie C., and Louis E. DeFrate. “Four-Point Bending Testing for Mechanical Assessment of Mouse Bone Structural Properties.Methods Mol Biol, vol. 2230, 2021, pp. 199–215. Pubmed, doi:10.1007/978-1-0716-1028-2_12.
Cutcliffe HC, DeFrate LE. Four-Point Bending Testing for Mechanical Assessment of Mouse Bone Structural Properties. Methods Mol Biol. 2021;2230:199–215.

Published In

Methods Mol Biol

DOI

EISSN

1940-6029

Publication Date

2021

Volume

2230

Start / End Page

199 / 215

Location

United States

Related Subject Headings

  • Weight-Bearing
  • Stress, Mechanical
  • Skull
  • Mice
  • Humans
  • Disease Models, Animal
  • Developmental Biology
  • Bone and Bones
  • Biomechanical Phenomena
  • Animals