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Initial displacement of the intra-articular surface after articular fracture correlates with PTA in C57BL/6 mice but not "superhealer" MRL/MpJ mice.

Publication ,  Journal Article
Vovos, TJ; Furman, BD; Huebner, JL; Kimmerling, KA; Utturkar, GM; Green, CL; Kraus, VB; Guilak, F; Olson, SA
Published in: J Orthop Res
September 2021

Posttraumatic arthritis (PTA) occurs commonly after articular fracture and may arise, in part, from joint surface incongruity after injury. MRL/MpJ (MRL) "super-healer" mice are protected from PTA compared to C57BL/6 (B6) mice following articular fracture. However, the relationship between the initial displacement of the articular surface, biologic response, and susceptibility to PTA after fracture remains unclear. The objective of this study was to assess whether joint incongruity after articular fracture, as measured by in vivo micro-computed tomography (microCT), could predict pathomechanisms of PTA in mice. B6 and MRL mice (n = 12/strain) received a closed articular fracture (fx) of the left tibial plateau. Articular incongruity was quantified as bone surface deviations (BSD) for each in vivo microCT scan obtained from pre-fx to 8 weeks post-fx, followed by histologic assessment of arthritis. Serum concentrations of bone formation (PINP) and bone resorption (CTX-I) biomarkers were quantified longitudinally. Both strains showed increases in surface incongruity over time, as measured by increases in BSD. In B6 mice, acute surface incongruity was significantly correlated to the severity of PTA (R 2  = 0.988; p = .0006), but not in MRL mice (R 2  = 0.224; p = .220). PINP concentrations significantly decreased immediately post-fx in B6 mice (p = .023) but not in MRL mice, indicating higher bone synthesis in MRL mice. MRL/MpJ mice demonstrate a unique biologic response to articular fracture such that the observed articular bone surface displacement does not correlate with the severity of subsequent PTA. Clinical Relevance: Identifying therapies to enhance acute biologic repair following articular fracture may mitigate the risk of articular surface displacement for PTA.

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Published In

J Orthop Res

DOI

EISSN

1554-527X

Publication Date

September 2021

Volume

39

Issue

9

Start / End Page

1977 / 1987

Location

United States

Related Subject Headings

  • X-Ray Microtomography
  • Orthopedics
  • Mice, Inbred Strains
  • Mice, Inbred C57BL
  • Mice
  • Intra-Articular Fractures
  • Arthritis
  • Animals
  • 4207 Sports science and exercise
  • 4003 Biomedical engineering
 

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Vovos, T. J., Furman, B. D., Huebner, J. L., Kimmerling, K. A., Utturkar, G. M., Green, C. L., … Olson, S. A. (2021). Initial displacement of the intra-articular surface after articular fracture correlates with PTA in C57BL/6 mice but not "superhealer" MRL/MpJ mice. J Orthop Res, 39(9), 1977–1987. https://doi.org/10.1002/jor.24912
Vovos, Tyler J., Bridgette D. Furman, Janet L. Huebner, Kelly A. Kimmerling, Gangadhar M. Utturkar, Cynthia L. Green, Virginia B. Kraus, Farshid Guilak, and Steven A. Olson. “Initial displacement of the intra-articular surface after articular fracture correlates with PTA in C57BL/6 mice but not "superhealer" MRL/MpJ mice.J Orthop Res 39, no. 9 (September 2021): 1977–87. https://doi.org/10.1002/jor.24912.
Vovos TJ, Furman BD, Huebner JL, Kimmerling KA, Utturkar GM, Green CL, et al. Initial displacement of the intra-articular surface after articular fracture correlates with PTA in C57BL/6 mice but not "superhealer" MRL/MpJ mice. J Orthop Res. 2021 Sep;39(9):1977–87.
Vovos, Tyler J., et al. “Initial displacement of the intra-articular surface after articular fracture correlates with PTA in C57BL/6 mice but not "superhealer" MRL/MpJ mice.J Orthop Res, vol. 39, no. 9, Sept. 2021, pp. 1977–87. Pubmed, doi:10.1002/jor.24912.
Vovos TJ, Furman BD, Huebner JL, Kimmerling KA, Utturkar GM, Green CL, Kraus VB, Guilak F, Olson SA. Initial displacement of the intra-articular surface after articular fracture correlates with PTA in C57BL/6 mice but not "superhealer" MRL/MpJ mice. J Orthop Res. 2021 Sep;39(9):1977–1987.
Journal cover image

Published In

J Orthop Res

DOI

EISSN

1554-527X

Publication Date

September 2021

Volume

39

Issue

9

Start / End Page

1977 / 1987

Location

United States

Related Subject Headings

  • X-Ray Microtomography
  • Orthopedics
  • Mice, Inbred Strains
  • Mice, Inbred C57BL
  • Mice
  • Intra-Articular Fractures
  • Arthritis
  • Animals
  • 4207 Sports science and exercise
  • 4003 Biomedical engineering