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Repulsive expansion dynamics in colony growth and gene expression.

Publication ,  Journal Article
Cao, Y; Neu, J; Blanchard, AE; Lu, T; You, L
Published in: PLoS computational biology
March 2021

Spatial expansion of a population of cells can arise from growth of microorganisms, plant cells, and mammalian cells. It underlies normal or dysfunctional tissue development, and it can be exploited as the foundation for programming spatial patterns. This expansion is often driven by continuous growth and division of cells within a colony, which in turn pushes the peripheral cells outward. This process generates a repulsion velocity field at each location within the colony. Here we show that this process can be approximated as coarse-grained repulsive-expansion kinetics. This framework enables accurate and efficient simulation of growth and gene expression dynamics in radially symmetric colonies with homogenous z-directional distribution. It is robust even if cells are not spherical and vary in size. The simplicity of the resulting mathematical framework also greatly facilitates generation of mechanistic insights.

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Published In

PLoS computational biology

DOI

EISSN

1553-7358

ISSN

1553-734X

Publication Date

March 2021

Volume

17

Issue

3

Start / End Page

e1008168

Related Subject Headings

  • N-Acetylmuramoyl-L-alanine Amidase
  • Models, Biological
  • Kinetics
  • Gene Regulatory Networks
  • Gene Expression
  • Cell Proliferation
  • Bioinformatics
  • Animals
  • 08 Information and Computing Sciences
  • 06 Biological Sciences
 

Citation

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Cao, Y., Neu, J., Blanchard, A. E., Lu, T., & You, L. (2021). Repulsive expansion dynamics in colony growth and gene expression. PLoS Computational Biology, 17(3), e1008168. https://doi.org/10.1371/journal.pcbi.1008168
Cao, Yangxiaolu, John Neu, Andrew E. Blanchard, Ting Lu, and Lingchong You. “Repulsive expansion dynamics in colony growth and gene expression.PLoS Computational Biology 17, no. 3 (March 2021): e1008168. https://doi.org/10.1371/journal.pcbi.1008168.
Cao Y, Neu J, Blanchard AE, Lu T, You L. Repulsive expansion dynamics in colony growth and gene expression. PLoS computational biology. 2021 Mar;17(3):e1008168.
Cao, Yangxiaolu, et al. “Repulsive expansion dynamics in colony growth and gene expression.PLoS Computational Biology, vol. 17, no. 3, Mar. 2021, p. e1008168. Epmc, doi:10.1371/journal.pcbi.1008168.
Cao Y, Neu J, Blanchard AE, Lu T, You L. Repulsive expansion dynamics in colony growth and gene expression. PLoS computational biology. 2021 Mar;17(3):e1008168.

Published In

PLoS computational biology

DOI

EISSN

1553-7358

ISSN

1553-734X

Publication Date

March 2021

Volume

17

Issue

3

Start / End Page

e1008168

Related Subject Headings

  • N-Acetylmuramoyl-L-alanine Amidase
  • Models, Biological
  • Kinetics
  • Gene Regulatory Networks
  • Gene Expression
  • Cell Proliferation
  • Bioinformatics
  • Animals
  • 08 Information and Computing Sciences
  • 06 Biological Sciences