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An Enhanced Tilted-Angle Acoustofluidic Chip for Cancer Cell Manipulation

Publication ,  Journal Article
Wu, F; Shen, MH; Yang, J; Wang, H; Mikhaylov, R; Clayton, A; Qin, X; Sun, C; Xie, Z; Cai, M; Wei, J; Liang, D; Yuan, F; Wu, Z; Fu, Y ...
Published in: IEEE Electron Device Letters
April 1, 2021
Published version (DOI)

In recent years, surface acoustic wave (SAW) devices have demonstrated great potentials and increasing applications in the manipulation of nano- and micro-particles including biological cells with the advantages of label-free, high sensitivity and accuracy. In this letter, we introduce a novel tilted-angle SAW devices to optimise the acoustic pressure inside a microchannel for cancer-cell manipulation. The SAW generation and acoustic radiation force are improved by seamlessly patterning electrodes in the space surrounding the microchannel. Comparisons between this novel SAW device and a conventional device show a 32% enhanced separation efficiency while the input power, manufacturing cost and fabrication effort remain the same. Effective separation of HeLa cancer cells from peripheral blood mononuclear cells is demonstrated. This novel SAW device has the advantages in minimizing device power consumption, lowering component footprint and increasing device density.

Duke Scholars

Fan Yuan
Author Fan Yuan Biomedical Engineering
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Published In

IEEE Electron Device Letters

DOI

10.1109/LED.2021.3062292

EISSN

1558-0563

ISSN

0741-3106

Publication Date

April 1, 2021

Volume

42

Issue

4

Start / End Page

577 / 580

Related Subject Headings

  • Applied Physics
  • 4009 Electronics, sensors and digital hardware
  • 0906 Electrical and Electronic Engineering
 

Citation

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Wu, F., Shen, M. H., Yang, J., Wang, H., Mikhaylov, R., Clayton, A., … Yang, X. (2021). An Enhanced Tilted-Angle Acoustofluidic Chip for Cancer Cell Manipulation. IEEE Electron Device Letters, 42(4), 577–580. https://doi.org/10.1109/LED.2021.3062292
Wu, F., M. H. Shen, J. Yang, H. Wang, R. Mikhaylov, A. Clayton, X. Qin, et al. “An Enhanced Tilted-Angle Acoustofluidic Chip for Cancer Cell Manipulation.” IEEE Electron Device Letters 42, no. 4 (April 1, 2021): 577–80. https://doi.org/10.1109/LED.2021.3062292.
Wu F, Shen MH, Yang J, Wang H, Mikhaylov R, Clayton A, et al. An Enhanced Tilted-Angle Acoustofluidic Chip for Cancer Cell Manipulation. IEEE Electron Device Letters. 2021 Apr 1;42(4):577–80.
Wu, F., et al. “An Enhanced Tilted-Angle Acoustofluidic Chip for Cancer Cell Manipulation.” IEEE Electron Device Letters, vol. 42, no. 4, Apr. 2021, pp. 577–80. Scopus, doi:10.1109/LED.2021.3062292.
Wu F, Shen MH, Yang J, Wang H, Mikhaylov R, Clayton A, Qin X, Sun C, Xie Z, Cai M, Wei J, Liang D, Yuan F, Wu Z, Fu Y, Yang Z, Sun X, Tian L, Yang X. An Enhanced Tilted-Angle Acoustofluidic Chip for Cancer Cell Manipulation. IEEE Electron Device Letters. 2021 Apr 1;42(4):577–580.

Published In

IEEE Electron Device Letters

DOI

10.1109/LED.2021.3062292

EISSN

1558-0563

ISSN

0741-3106

Publication Date

April 1, 2021

Volume

42

Issue

4

Start / End Page

577 / 580

Related Subject Headings

  • Applied Physics
  • 4009 Electronics, sensors and digital hardware
  • 0906 Electrical and Electronic Engineering