Fan Yuan | Scholars@Duke

Fan Yuan
Professor of Biomedical Engineering

Dr. Yuan has extensive experiences in analysis of therapeutic agent transport in mammalian cells, tissues, and organs, and development of effective strategies, design principles, and new technologies that can be used to facilitate the transport. The goal of his research is to improve delivery of therapeutic agents to their targets, which is crucial in treatment and prevention of diseases. He has published >100 scientific papers in peer-reviewed journals, and a textbook on transport analysis in biological systems that has been used to teach undergraduate and graduate courses in many universities.

Current Research Interests

Principles and mechanisms of delivery for drugs, genes, and vaccines; pharmacokinetics; electrotransfer or electroporation technology; and tumor pathophysiology.

Current Appointments & Affiliations

Professor of Biomedical Engineering, Biomedical Engineering, Pratt School of Engineering 2009
Professor in Ophthalmology, Ophthalmology, Clinical Science Departments 2013
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 1996

Contact Information

Duke Box 90281, Durham, NC 27708-0281
Rm 1385, Fciemas, Duke Univers, Durham, NC 27708-0281
fyuan@duke.edu (919) 660-5411
Google Scholar
Lab website

Background
Education, Training, & Certifications
- Ph.D., City University of New York 1990
- M.S., Peking University (China) 1985
- B.S., Peking University (China) 1983
Previous Appointments & Affiliations
- Director of Graduate Studies for Master, Biomedical Engineering, Pratt School of Engineering 2013 - 2016
- Assistant Professor in Ophthalmology, Ophthalmology, Clinical Science Departments 2010 - 2013
- Associate Professor of Biomedical Engineering, Biomedical Engineering, Pratt School of Engineering 2003 - 2009
- Assistant Professor in Ophthalmology, Ophthalmology, Clinical Science Departments 2002 - 2003
- Assistant Professor of Biomedical Engineering, Biomedical Engineering, Pratt School of Engineering 1996 - 2003
Recognition
Awards & Honors
Research
Selected Grants
- Chemically Assisted Electrotransfer of DNA awarded by National Institutes of Health 2022 - 2027
- University Training Program in Biomolecular and Tissue Engineering awarded by National Institutes of Health 1994 - 2027
- Computational Design of Antibody-Drug-Excipient Nanoparticles awarded by National Institutes of Health 2023 - 2026
- Non-Canonical Pathways for Electrogene Transfer awarded by National Institutes of Health 2018 - 2023
- CIVICS A - Option 23B awarded by National Institute of Allergy and Infectious Diseases 2020 - 2022
- Pharmacological Sciences Training Program awarded by National Institutes of Health 1975 - 2020
- Investigation of Endocytosis Involved in Electrotransfection awarded by National Institutes of Health 2013 - 2018
- OCT measurement of TM/SC stiffness in living mice awarded by BrightFocus Foundation 2015 - 2017
- Analysis of DNA transport in electrotransfected cells awarded by National Science Foundation 2013 - 2017
- Shear stress regulation of barrier function in Schlemm's canal awarded by National Institutes of Health 2014 - 2016
- Biosensor Biocompatibility awarded by National Institutes of Health 1999 - 2015
- Delivery of Bacterial Therapeutics to Solid Tumors awarded by National Science Foundation 2009 - 2013
- Intravital point-scanning confocal microscope awarded by National Institutes of Health 2010 - 2011
- Electric Field-Mediated Gene Delivery in MCL Tumor Model awarded by National Institutes of Health 2006 - 2010
- Training in Biomolecular and Tissue Engineering awarded by National Institutes of Health 2003 - 2009
- Electric Field-Forced Gene Transfer in Solid Tumors awarded by National Institutes of Health 2002 - 2009
- Electric Field-Forced Gene Transfer in Solid Tumors awarded by National Institutes of Health 2002 - 2007
- CAREER: Improving Convective Transport of Drugs and Genes in Solid Tumors awarded by National Science Foundation 2000 - 2006
- Upgrade of a Shared Instrumentation Resource in the PSOE: The Laser Scanning Confocal Microscope awarded by Lord Foundation of North Carolina 2002 - 2005
- missing activity
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Jin, Z., & Yuan, F. (2023). A Double-Permeability Poroelasticity Model for Fluid Transport in a Biological Tissue. Transport in Porous Media, 147(1), 169–195. https://doi.org/10.1007/s11242-023-01904-w
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  - Wang, L., Chang, C.-C., Sylvers, J., & Yuan, F. (2021). A statistical framework for determination of minimal plasmid copy number required for transgene expression in mammalian cells. Bioelectrochemistry (Amsterdam, Netherlands), 138, 107731. https://doi.org/10.1016/j.bioelechem.2020.107731
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  - Wu, F., Shen, M. H., Yang, J., Wang, H., Mikhaylov, R., Clayton, A., … Yang, X. (2021). An Enhanced Tilted-Angle Acoustofluidic Chip for Cancer Cell Manipulation. Ieee Electron Device Letters, 42(4), 577–580. https://doi.org/10.1109/LED.2021.3062292
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  - Sun, C., Wu, F., Fu, Y., Wallis, D. J., Mikhaylov, R., Yuan, F., … Yang, X. (2020). Thin film Gallium nitride (GaN) based acoustofluidic Tweezer: Modelling and microparticle manipulation. Ultrasonics, 108, 106202. https://doi.org/10.1016/j.ultras.2020.106202
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  - Huang, J., Sachdeva, M., Xu, E., Robinson, T. J., Luo, L., Ma, Y., … Kirsch, D. G. (2020). The Long Noncoding RNA NEAT1 Promotes Sarcoma Metastasis by Regulating RNA Splicing Pathways. Mol Cancer Res, 18(10), 1534–1544. https://doi.org/10.1158/1541-7786.MCR-19-1170
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  - Wang, Y., Chang, C.-C., Wang, L., & Yuan, F. (2020). Enhancing Cell Viability and Efficiency of Plasmid DNA Electrotransfer Through Reducing Plasma Membrane Permeabilization. Bioelectricity, 2(3), 251–257. https://doi.org/10.1089/bioe.2020.0007
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  - Wang, C., Chang, C.-C., Wang, L., & Yuan, F. (2020). Inhibition of Caspases Improves Non-Viral T Cell Receptor Editing. Cancers, 12(9), E2603. https://doi.org/10.3390/cancers12092603
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  - Mikhaylov, R., Wu, F., Wang, H., Clayton, A., Sun, C., Xie, Z., … Yang, X. (2020). Correction: Development and characterisation of acoustofluidic devices using detachable electrodes made from PCB. Lab on a Chip, 20(17), 3278. https://doi.org/10.1039/d0lc90070b
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  - Sun, C., Wu, F., Wallis, D. J., Shen, M. H., Yuan, F., Yang, J., … Yang, X. (2020). Gallium Nitride: A Versatile Compound Semiconductor as Novel Piezoelectric Film for Acoustic Tweezer in Manipulation of Cancer Cells. Ieee Transactions on Electron Devices, 67(8), 3355–3361. https://doi.org/10.1109/TED.2020.3002498
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  - Mao, M., Chang, C.-C., Pickar-Oliver, A., Cervia, L. D., Wang, L., Ji, J., … Yuan, F. (2020). Redirecting Vesicular Transport to Improve Nonviral Delivery of Molecular Cargo. Adv Biosyst, 4(8), e2000059. https://doi.org/10.1002/adbi.202000059
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  - Mikhaylov, R., Wu, F., Wang, H., Clayton, A., Sun, C., Xie, Z., … Yang, X. (2020). Development and characterisation of acoustofluidic devices using detachable electrodes made from PCB. Lab on a Chip, 20(10), 1807–1814. https://doi.org/10.1039/c9lc01192g
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  - Wang, L., Miller, S. E., & Yuan, F. (2018). Ultrastructural Analysis of Vesicular Transport in Electrotransfection. Microsc Microanal, 24(5), 553–563. https://doi.org/10.1017/S143192761801509X
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  - Cervia, L. D., & Yuan, F. (2018). Current Progress in Electrotransfection as a Nonviral Method for Gene Delivery. Molecular Pharmaceutics, 15(9), 3617–3624. https://doi.org/10.1021/acs.molpharmaceut.8b00207
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  - Tao, K., Fan, Z., Sun, L., Makam, P., Tian, Z., Ruegsegger, M., … Li, J. (2018). Quantum confined peptide assemblies with tunable visible to near-infrared spectral range. Nature Communications, 9(1), 3217. https://doi.org/10.1038/s41467-018-05568-9
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  - Cervia, L. D., Chang, C.-C., Wang, L., Mao, M., & Yuan, F. (2018). Enhancing Electrotransfection Efficiency through Improvement in Nuclear Entry of Plasmid DNA. Molecular Therapy. Nucleic Acids, 11, 263–271. https://doi.org/10.1016/j.omtn.2018.02.009
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  - Lei, Y., Han, H., Yuan, F., Javeed, A., & Zhao, Y. (2017). The brain interstitial system: Anatomy, modeling, in vivo measurement, and applications. Progress in Neurobiology, 157, 230–246. https://doi.org/10.1016/j.pneurobio.2015.12.007
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  - Chang, J., Huang, J., Li, L., Liu, Z., & Yuan, F. (2017). Stiffness characterization of anisotropic trabecular meshwork. Journal of Biomechanics, 61, 144–150. https://doi.org/10.1016/j.jbiomech.2017.07.021
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  - Mao, M., Wang, L., Chang, C.-C., Rothenberg, K. E., Huang, J., Wang, Y., … Yuan, F. (2017). Involvement of a Rac1-Dependent Macropinocytosis Pathway in Plasmid DNA Delivery by Electrotransfection. Mol Ther, 25(3), 803–815. https://doi.org/10.1016/j.ymthe.2016.12.009
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  - Cervia, L. D., Chang, C.-C., Wang, L., & Yuan, F. (2017). Distinct effects of endosomal escape and inhibition of endosomal trafficking on gene delivery via electrotransfection. Plos One, 12(2), e0171699. https://doi.org/10.1371/journal.pone.0171699
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  - Chang, C.-C., Mao, M., Liu, Y., Wu, M., Vo-Dinh, T., & Yuan, F. (2016). Improvement in Electrotransfection of Cells Using Carbon-Based Electrodes. Cellular and Molecular Bioengineering, 9(4), 538–545. https://doi.org/10.1007/s12195-016-0452-9
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  - Li, G., Mukherjee, D., Navarro, I., Ashpole, N. E., Sherwood, J. M., Chang, J., … Stamer, W. D. (2016). Visualization of conventional outflow tissue responses to netarsudil in living mouse eyes. Eur J Pharmacol, 787, 20–31. https://doi.org/10.1016/j.ejphar.2016.04.002
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  - Huang, J., Wang, L., Xiong, C., & Yuan, F. (2016). Elastic hydrogel as a sensor for detection of mechanical stress generated by single cells grown in three-dimensional environment. Biomaterials, 98, 103–112. https://doi.org/10.1016/j.biomaterials.2016.04.024
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  - Yuan, F., Schieber, A. T., Camras, L. J., Harasymowycz, P. J., Herndon, L. W., & Allingham, R. R. (2016). Mathematical Modeling of Outflow Facility Increase With Trabecular Meshwork Bypass and Schlemm Canal Dilation. J Glaucoma, 25(4), 355–364. https://doi.org/10.1097/IJG.0000000000000248
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  - Huang, J., Camras, L. J., & Yuan, F. (2015). Mechanical analysis of rat trabecular meshwork. Soft Matter, 11(14), 2857–2865. https://doi.org/10.1039/c4sm01949k
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  - Lee, T. J., Wong, J., Bae, S., Lee, A. J., Lopatkin, A., Yuan, F., & You, L. (2015). A power-law dependence of bacterial invasion on mammalian host receptors. Plos Computational Biology, 11(4), e1004203. https://doi.org/10.1371/journal.pcbi.1004203
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  - Cheung, T. M., Yan, J. B., Fu, J. J., Huang, J., Yuan, F., & Truskey, G. A. (2015). Endothelial Cell Senescence Increases Traction Forces due to Age-Associated Changes in the Glycocalyx and SIRT1. Cellular and Molecular Bioengineering, 8(1), 63–75. https://doi.org/10.1007/s12195-014-0371-6
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  - Yuan, Y., Huang, J., Fang, J., Yuan, F., & Xiong, C. (2015). A self-adaptive sampling digital image correlation algorithm for accurate displacement measurement. Optics and Lasers in Engineering, 65, 57–63. https://doi.org/10.1016/j.optlaseng.2014.05.006
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  - Novak, M. T., Yuan, F., & Reichert, W. M. (2014). Macrophage embedded fibrin gels: an in vitro platform for assessing inflammation effects on implantable glucose sensors. Biomaterials, 35(36), 9563–9572. https://doi.org/10.1016/j.biomaterials.2014.08.002
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  - Camras, L. J., Stamer, W. D., Epstein, D., Gonzalez, P., & Yuan, F. (2014). Circumferential tensile stiffness of glaucomatous trabecular meshwork. Invest Ophthalmol Vis Sci, 55(2), 814–823. https://doi.org/10.1167/iovs.13-13091
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  - Liu, C., Li, C.-Y., & Yuan, F. (2014). Mathematical modeling of the Phoenix Rising pathway. Plos Comput Biol, 10(2), e1003461. https://doi.org/10.1371/journal.pcbi.1003461
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  - Chang, C.-C., Wu, M., & Yuan, F. (2014). Role of specific endocytic pathways in electrotransfection of cells. Molecular Therapy. Methods & Clinical Development, 1, 14058. https://doi.org/10.1038/mtm.2014.58
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  - Li, G., Farsiu, S., Qiu, J., Dixon, A., Song, C., McKinnon, S. J., … Stamer, W. D. (2014). Disease progression in iridocorneal angle tissues of BMP2-induced ocular hypertensive mice with optical coherence tomography. Mol Vis, 20, 1695–1709.
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  - Yuan, Y., Huang, J., Peng, X., Xiong, C., Fang, J., & Yuan, F. (2014). Accurate displacement measurement via a self-adaptive digital image correlation method based on a weighted ZNSSD criterion. Optics and Lasers in Engineering, 52(1), 75–85. https://doi.org/10.1016/j.optlaseng.2013.07.016
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  - Novak, M. T., Yuan, F., & Reichert, W. M. (2013). Predicting glucose sensor behavior in blood using transport modeling: relative impacts of protein biofouling and cellular metabolic effects. Journal of Diabetes Science and Technology, 7(6), 1547–1560. https://doi.org/10.1177/193229681300700615
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  - Huang, J., Pan, X., Peng, X., Yuan, Y., Xiong, C., Fang, J., & Yuan, F. (2013). Digital Image Correlation with Self-Adaptive Gaussian Windows. Experimental Mechanics, 53(3), 505–512. https://doi.org/10.1007/s11340-012-9639-8
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  - McGuire, S., & Yuan, F. (2012). Improving interstitial transport of macromolecules through reduction in cell volume fraction in tumor tissues. Nanomedicine : Nanotechnology, Biology, and Medicine, 8(7), 1088–1095. https://doi.org/10.1016/j.nano.2011.12.009
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  - Camras, L. J., Yuan, F., Fan, S., Samuelson, T. W., Ahmed, I. K., Schieber, A. T., & Toris, C. B. (2012). A novel Schlemm's Canal scaffold increases outflow facility in a human anterior segment perfusion model. Investigative Ophthalmology & Visual Science, 53(10), 6115–6121. https://doi.org/10.1167/iovs.12-9570
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  - Camras, L. J., Stamer, W. D., Epstein, D., Gonzalez, P., & Yuan, F. (2012). Differential effects of trabecular meshwork stiffness on outflow facility in normal human and porcine eyes. Invest Ophthalmol Vis Sci, 53(9), 5242–5250. https://doi.org/10.1167/iovs.12-9825
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  - Rivera, S., & Yuan, F. (2012). Critical issues in delivery of RNAi therapeutics in vivo. Current Pharmaceutical Biotechnology, 13(7), 1279–1291. https://doi.org/10.2174/138920112800624300
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  - Elliott, N. T., & Yuan, F. (2012). A microfluidic system for investigation of extravascular transport and cellular uptake of drugs in tumors. Biotechnology and Bioengineering, 109(5), 1326–1335. https://doi.org/10.1002/bit.24397
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  - Luna, C., Li, G., Huang, J., Qiu, J., Wu, J., Yuan, F., … Gonzalez, P. (2012). Regulation of trabecular meshwork cell contraction and intraocular pressure by miR-200c. Plos One, 7(12), e51688. https://doi.org/10.1371/journal.pone.0051688
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  - Long, M., & Yuan, F. (2011). Special issue: Experiments and modeling in microand nano-biomechanics. Cellular and Molecular Bioengineering, 4(3), 325–326. https://doi.org/10.1007/s12195-011-0192-9
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  - Elliott, N., Lee, T., You, L., & Yuan, F. (2011). Proliferation behavior of E. coli in a three-dimensional in vitro tumor model. Integrative Biology : Quantitative Biosciences From Nano to Macro, 3(6), 696–705. https://doi.org/10.1039/c0ib00137f
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  - Elliott, N. T., & Yuan, F. (2011). A review of three-dimensional in vitro tissue models for drug discovery and transport studies. Journal of Pharmaceutical Sciences, 100(1), 59–74. https://doi.org/10.1002/jps.22257
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  - Henshaw, J., Mossop, B., & Yuan, F. (2011). Enhancement of electric field-mediated gene delivery through pretreatment of tumors with a hyperosmotic mannitol solution. Cancer Gene Therapy, 18(1), 26–33. https://doi.org/10.1038/cgt.2010.51
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  - Lin, C.-W., Gonzalez, P., & Yuan, F. (2011). Cellular pharmacokinetic and pharmacodynamic analyses of ethacrynic acid: Implications in topical drug delivery in the eye. Mol Vis, 17, 2507–2515.
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  - Wu, M., & Yuan, F. (2011). Membrane binding of plasmid DNA and endocytic pathways are involved in electrotransfection of mammalian cells. Plos One, 6(6), e20923. https://doi.org/10.1371/journal.pone.0020923
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  - Novak, M. T., Yuan, F., & Reichert, W. M. (2010). Modeling the relative impact of capsular tissue effects on implanted glucose sensor time lag and signal attenuation. Analytical and Bioanalytical Chemistry, 398(4), 1695–1705. https://doi.org/10.1007/s00216-010-4097-6
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  - Lin, C.-W., & Yuan, F. (2010). Numerical simulations of ethacrynic acid transport from precorneal region to trabecular meshwork. Annals of Biomedical Engineering, 38(3), 935–944. https://doi.org/10.1007/s10439-010-9947-z
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  - Novak, M. T., Yuan, F., & Reichert, W. M. (2010). Modeling the Relative Effects of Biofouling, Fibrous Encapsulation and Microvessel Density on Implanted Glucose Sensor Performance. Biophysical Journal, 98(3), 407a-407a. https://doi.org/10.1016/j.bpj.2009.12.2193
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  - Yarmolenko, P. S., Zhao, Y., Landon, C., Spasojevic, I., Yuan, F., Needham, D., … Dewhirst, M. W. (2010). Comparative effects of thermosensitive doxorubicin-containing liposomes and hyperthermia in human and murine tumours. Int J Hyperthermia, 26(5), 485–498. https://doi.org/10.3109/02656731003789284
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  - Chen, Q., Krol, A., Wright, A., Needham, D., Dewhirst, M. W., & Yuan, F. (2008). Tumor microvascular permeability is a key determinant for antivascular effects of doxorubicin encapsulated in a temperature sensitive liposome. Int J Hyperthermia, 24(6), 475–482. https://doi.org/10.1080/02656730701854767
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  - Henshaw, J., Mossop, B., & Yuan, F. (2008). Relaxin treatment of solid tumors: effects on electric field-mediated gene delivery. Molecular Cancer Therapeutics, 7(8), 2566–2573. https://doi.org/10.1158/1535-7163.mct-08-0435
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  - Henshaw, J. W., & Yuan, F. (2008). Field distribution and DNA transport in solid tumors during electric field-mediated gene delivery. Journal of Pharmaceutical Sciences, 97(2), 691–711. https://doi.org/10.1002/jps.21000
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  - Tong, S., & Yuan, F. (2008). Dose response of angiogenesis to basic fibroblast growth factor in rat corneal pocket assay: II. Numerical simulations. Microvascular Research, 75(1), 16–24. https://doi.org/10.1016/j.mvr.2007.09.005
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  - Tong, S., & Yuan, F. (2008). Dose response of angiogenesis to basic fibroblast growth factor in rat corneal pocket assay: I. Experimental characterizations. Microvascular Research, 75(1), 10–15. https://doi.org/10.1016/j.mvr.2007.06.002
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  - Yuan, F., & Huang, A. (2008). Effects of transmural fluid exchange on tumor blood flow. Biorheology, 45(1–2), 39–39.
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  - Zaharoff, D. A., Henshaw, J. W., Mossop, B., & Yuan, F. (2008). Mechanistic analysis of electroporation-induced cellular uptake of macromolecules. Experimental Biology and Medicine (Maywood, N.J.), 233(1), 94–105. https://doi.org/10.3181/0704-rm-113
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  - Henshaw, J. W., Zaharoff, D. A., Mossop, B. J., & Yuan, F. (2007). Electric field-mediated transport of plasmid DNA in tumor interstitium in vivo. Bioelectrochemistry (Amsterdam, Netherlands), 71(2), 233–242. https://doi.org/10.1016/j.bioelechem.2007.07.005
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  - Mossop, B. J., Barr, R. C., Henshaw, J. W., & Yuan, F. (2007). Electric fields around and within single cells during electroporation-a model study. Annals of Biomedical Engineering, 35(7), 1264–1275. https://doi.org/10.1007/s10439-007-9282-1
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  - Lin, C.-W., Wang, Y., Challa, P., Epstein, D. L., & Yuan, F. (2007). Transscleral diffusion of ethacrynic acid and sodium fluorescein. Mol Vis, 13, 243–251.
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  - Norton, L. W., Yuan, F., & Reichert, W. M. (2007). Glucose recovery with bare and hydrogel-coated microdialysis probes: experiment and simulation of temporal effects. Analytical Chemistry, 79(2), 445–452. https://doi.org/10.1021/ac061234p
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  - Reza, F., Chandran, K., Feltz, M., Heinz, A., Josephs, E., O’Brien, P., … Tian, J. (2007). Engineering novel synthetic biological systems. Iet Synthetic Biology, 1, 48–52.
  - Henshaw, J. W., Zaharoff, D. A., Mossop, B. J., & Yuan, F. (2006). A single molecule detection method for understanding mechanisms of electric field-mediated interstitial transport of genes. Bioelectrochemistry (Amsterdam, Netherlands), 69(2), 248–253. https://doi.org/10.1016/j.bioelechem.2006.03.006
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  - Mossop, B. J., Barr, R. C., Henshaw, J. W., Zaharoff, D. A., & Yuan, F. (2006). Electric fields in tumors exposed to external voltage sources: implication for electric field-mediated drug and gene delivery. Annals of Biomedical Engineering, 34(10), 1564–1572. https://doi.org/10.1007/s10439-006-9151-3
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  - Shan, S., Flowers, C., Peltz, C. D., Sweet, H., Maurer, N., Kwon, E.-J., … Dewhirst, M. W. (2006). Preferential extravasation and accumulation of liposomal vincristine in tumor comparing to normal tissue enhances antitumor activity. Cancer Chemother Pharmacol, 58(2), 245–255. https://doi.org/10.1007/s00280-005-0145-x
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  - McGuire, S., Zaharoff, D., & Yuan, F. (2006). Nonlinear dependence of hydraulic conductivity on tissue deformation during intratumoral infusion. Annals of Biomedical Engineering, 34(7), 1173–1181. https://doi.org/10.1007/s10439-006-9136-2
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  - Ponce, A. M., Vujaskovic, Z., Yuan, F., Needham, D., & Dewhirst, M. W. (2006). Hyperthermia mediated liposomal drug delivery. Int J Hyperthermia, 22(3), 205–213. https://doi.org/10.1080/02656730600582956
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  - Dreher, M. R., Liu, W., Michelich, C. R., Dewhirst, M. W., Yuan, F., & Chilkoti, A. (2006). Tumor vascular permeability, accumulation, and penetration of macromolecular drug carriers. J Natl Cancer Inst, 98(5), 335–344. https://doi.org/10.1093/jnci/djj070
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  - Wang, Y., Wang, H., Li, C.-Y., & Yuan, F. (2006). Effects of rate, volume, and dose of intratumoral infusion on virus dissemination in local gene delivery. Mol Cancer Ther, 5(2), 362–366. https://doi.org/10.1158/1535-7163.MCT-05-0266
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  - Wang, Y., & Yuan, F. (2006). Delivery of viral vectors to tumor cells: extracellular transport, systemic distribution, and strategies for improvement. Annals of Biomedical Engineering, 34(1), 114–127. https://doi.org/10.1007/s10439-005-9007-2
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  - Tong, S., Chen, Q., Shan, S.-Q., Dewhirst, M. W., & Yuan, F. (2006). Quantitative comparison of the inhibitory effects of GW5638 and tamoxifen on angiogenesis in the cornea pocket assay. Angiogenesis, 9(2), 53–58. https://doi.org/10.1007/s10456-006-9029-x
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  - Henshaw, J. W., Zaharoff, D. A., Mossop, B. J., & Yuan, F. (2005). In vivo electric field-mediated transport of plasmid DNA in tumor interstitium. Proceedings of the 2005 Summer Bioengineering Conference, 2005, 149–150.
  - Lin, C. W., & Yuan, F. (2005). Numerical simulations of transcorneal tranport of ethacrynic acid. Proceedings of the 2005 Summer Bioengineering Conference, 2005, 289–290.
  - Mossop, B. J., Henshaw, J. W., Zaharoff, D. A., & Yuan, F. (2005). Ex vivo and in vivo mapping of electric fields in tumor tissues. Proceedings of the 2005 Summer Bioengineering Conference, 2005, 197–198.
  - Wang, Y., Chen, Q., & Yuan, F. (2005). Alginate encapsulation is a highly reproducible method for tumor cell implantation in dorsal skinfold chambers. Biotechniques, 39(6), 834–839. https://doi.org/10.2144/000112082
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  - Wang, Y., Liu, S., Li, C.-Y., & Yuan, F. (2005). A novel method for viral gene delivery in solid tumors. Cancer Res, 65(17), 7541–7545. https://doi.org/10.1158/0008-5472.CAN-05-1112
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  - Wang, Y., Yang, Z., Liu, S., Kon, T., Krol, A., Li, C.-Y., & Yuan, F. (2005). Characterisation of systemic dissemination of nonreplicating adenoviral vectors from tumours in local gene delivery. Br J Cancer, 92(8), 1414–1420. https://doi.org/10.1038/sj.bjc.6602494
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  - Chen, Q., Tong, S., Dewhirst, M. W., & Yuan, F. (2004). Targeting tumor microvessels using doxorubicin encapsulated in a novel thermosensitive liposome. Mol Cancer Ther, 3(10), 1311–1317.
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  - Mossop, B. J., Barr, R. C., Zaharoff, D. A., & Yuan, F. (2004). Electric fields within cells as a function of membrane resistivity--a model study. Ieee Transactions on Nanobioscience, 3(3), 225–231. https://doi.org/10.1109/tnb.2004.833703
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  - Wang, Y., Challa, P., Epstein, D. L., & Yuan, F. (2004). Controlled release of ethacrynic acid from poly(lactide-co-glycolide) films for glaucoma treatment. Biomaterials, 25(18), 4279–4285. https://doi.org/10.1016/j.biomaterials.2003.10.075
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  - Zaharoff, D. A., & Yuan, F. (2004). Effects of pulse strength and pulse duration on in vitro DNA electromobility. Bioelectrochemistry (Amsterdam, Netherlands), 62(1), 37–45. https://doi.org/10.1016/j.bioelechem.2003.10.011
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  - Wang, Y., Li, C.-Y., & Yuan, F. (2004). Systemic virus dissemination during local gene delivery in solid tumors and its control with an alginate solution. Conf Proc Ieee Eng Med Biol Soc, 2004, 3524–3526. https://doi.org/10.1109/IEMBS.2004.1403991
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  - Wang, Y., Hu, J. K., Krol, A., Li, Y.-P., Li, C.-Y., & Yuan, F. (2003). Systemic dissemination of viral vectors during intratumoral injection. Mol Cancer Ther, 2(11), 1233–1242.
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  - Sampson, J. H., Akabani, G., Archer, G. E., Bigner, D. D., Berger, M. S., Friedman, A. H., … Pastan, I. (2003). Progress report of a Phase I study of the intracerebral microinfusion of a recombinant chimeric protein composed of transforming growth factor (TGF)-alpha and a mutated form of the Pseudomonas exotoxin termed PE-38 (TP-38) for the treatment of malignant brain tumors. J Neurooncol, 65(1), 27–35. https://doi.org/10.1023/a:1026290315809
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  - Lockhart, A. C., Braun, R. D., Yu, D., Ross, J. R., Dewhirst, M. W., Humphrey, J. S., … Hurwitz, H. I. (2003). Reduction of wound angiogenesis in patients treated with BMS-275291, a broad spectrum matrix metalloproteinase inhibitor. Clin Cancer Res, 9(2), 586–593.
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  - Krol, A., Dewhirst, M. W., & Yuan, F. (2003). Effects of cell damage and glycosaminoglycan degradation on available extravascular space of different dextrans in a rat fibrosarcoma. Int J Hyperthermia, 19(2), 154–164. https://doi.org/10.1080/02656730210166519
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  - Lockhart, A. C., Braun, R. D., Yu, D., Ross, J. R., Dewhirst, M. W., Klitzman, B., … Hurwitz, H. I. (2003). A clinical model of dermal wound angiogenesis. Wound Repair Regen, 11(4), 306–313. https://doi.org/10.1046/j.1524-475x.2003.11411.x
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  - Lin, C. W., Wang, Y., & Yuan, F. (2002). Transscleral diffusion of ethacrynic acid and sodium fluorescein. Annual International Conference of the Ieee Engineering in Medicine and Biology Proceedings, 1, 515.
  - McGuire, S. M., & Yuan, F. (2002). Effects of tissue stretching or cell shrinkage on penetration depth of macromolecules in a rat fibrosarcoma. Annual International Conference of the Ieee Engineering in Medicine and Biology Proceedings, 1, 516–517.
  - Wang, Y., Hu, J. K., Krol, A., Li, Y. P., Li, C. Y., & Yuan, F. (2002). Reducing systemic toxicity in local tumor gene therapy using an alginate solution. Annual International Conference of the Ieee Engineering in Medicine and Biology Proceedings, 1, 565.
  - Zaharoff, D. A., & Yuan, F. (2002). Effects of electric pulse strength and pulse duration on plasmid DNA electromobility. Annual International Conference of the Ieee Engineering in Medicine and Biology Proceedings, 1, 546–547.
  - Zaharoff, D. A., Barr, R. C., Li, C.-Y., & Yuan, F. (2002). Electromobility of plasmid DNA in tumor tissues during electric field-mediated gene delivery. Gene Ther, 9(19), 1286–1290. https://doi.org/10.1038/sj.gt.3301799
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  - Tong, S., & Yuan, F. (2002). An equivalent length model of microdialysis sampling. Journal of Pharmaceutical and Biomedical Analysis, 28(2), 269–278. https://doi.org/10.1016/s0731-7085(01)00565-9
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  - Dewhirst, M. W., Shan, S., Cao, Y., Moeller, B., Yuan, F., & Li, C.-Y. (2002). Intravital fluorescence facilitates measurement of multiple physiologic functions and gene expression in tumors of live animals. Dis Markers, 18(5–6), 293–311. https://doi.org/10.1155/2002/820102
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  - Yuan, F., Krol, A., & Tong, S. (2001). Available space and extracellular transport of macromolecules: effects of pore size and connectedness. Annals of Biomedical Engineering, 29(12), 1150–1158. https://doi.org/10.1114/1.1424915
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  - McGuire, S., & Yuan, F. (2001). Quantitative analysis of intratumoral infusion of color molecules. American Journal of Physiology. Heart and Circulatory Physiology, 281(2), H715–H721. https://doi.org/10.1152/ajpheart.2001.281.2.h715
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  - Lohr, F., Lo, D. Y., Zaharoff, D. A., Hu, K., Zhang, X., Li, Y., … Li, C. Y. (2001). Effective tumor therapy with plasmid-encoded cytokines combined with in vivo electroporation. Cancer Res, 61(8), 3281–3284.
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  - Tong, S., & Yuan, F. (2001). Numerical simulations of angiogenesis in the cornea. Microvascular Research, 61(1), 14–27. https://doi.org/10.1006/mvre.2000.2282
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  - Krol, A., Yuan, F., & Dewhirst, M. (2000). Available volume fraction of macromolecules in solid tumors. Annals of Biomedical Engineering, 28(SUPPL. 1).
  - McGuire, S., Zhang, X. Y., Dewhirst, M., & Yuan, F. (2000). New technique for measurement of distribution volume of color molecules in solid tumors. Annals of Biomedical Engineering, 28(SUPPL. 1).
  - Tong, S., & Yuan, F. (2000). Numerical simulations of angiogenesis in the cornea. Annals of Biomedical Engineering, 28(SUPPL. 1).
  - Yuan, F., Zaharoff, D., Zhang, X. Y., Lohr, F., Dewhirst, M. W., & Li, C. Y. (2000). Delivery of plasmid DNA through intratumoral infusion and electroporation. American Society of Mechanical Engineers, Bioengineering Division (Publication) Bed, 48, 173–176.
  - Zaharoff, D., Barr, R., Li, C. Y., & Yuan, F. (2000). Mobility of plasmid DNA subject to pulsed electric fields. Annals of Biomedical Engineering, 28(SUPPL. 1).
  - Zhang, X. Y., Luck, J., Dewhirst, M. W., & Yuan, F. (2000). Interstitial hydraulic conductivity in a fibrosarcoma. Am J Physiol Heart Circ Physiol, 279(6), H2726–H2734. https://doi.org/10.1152/ajpheart.2000.279.6.H2726
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  - Dellian, M., Yuan, F., Trubetskoy, V. S., Torchilin, V. P., & Jain, R. K. (2000). Vascular permeability in a human tumour xenograft: molecular charge dependence. British Journal of Cancer, 82(9), 1513–1518. https://doi.org/10.1054/bjoc.1999.1171
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  - Krol, A., Nagaraj, S., Dewhirst, M., & Yuan, F. (2000). Available volume fraction of macromolecules in tumor tissues. Faseb Journal, 14(4), A167–A167.
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  - Tong, S., & Yuan, F. (2000). Numerical simulation of angiogenesis in the cornea. Faseb Journal, 14(4), A35–A35.
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  - McGuire, S., Zhang, X.-Y., Dewhirst, M., & Yuan, F. (2000). New technique for measurement of distribution volume of color molecules in solid tumors. Annals of Biomedical Engineering, 28(SUPPL 1), 25.
  - Tong, S., & Yuan, F. (2000). Numerical simulations of angiogenesis in the cornea. Annals of Biomedical Engineering, 28(SUPPL 1), 77.
  - Zaharoff, D., Barr, R., Li, C.-Y., & Yuan, F. (2000). Mobility of plasmid DNA subject to pulsed electric fields. Annals of Biomedical Engineering, 28(SUPPL 1), 25.
  - Krol, A., Maresca, J., Dewhirst, M. W., & Yuan, F. (1999). Available volume fraction of macromolecules in the extravascular space of a fibrosarcoma: implications for drug delivery. Cancer Res, 59(16), 4136–4141.
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  - Monsky, W. L., Fukumura, D., Gohongi, T., Ancukiewcz, M., Weich, H. A., Torchilin, V. P., … Jain, R. K. (1999). Augmentation of transvascular transport of macromolecules and nanoparticles in tumors using vascular endothelial growth factor. Cancer Research, 59(16), 4129–4135.
  - Jain, R. K., Safabakhsh, N., Sckell, A., Chen, Y., Jiang, P., Benjamin, L., … Keshet, E. (1998). Endothelial cell death, angiogenesis, and microvascular function after castration in an androgen-dependent tumor: role of vascular endothelial growth factor. Proceedings of the National Academy of Sciences of the United States of America, 95(18), 10820–10825. https://doi.org/10.1073/pnas.95.18.10820
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  - Yuan, F. (1998). Transvascular drug delivery in solid tumors. Seminars in Radiation Oncology, 8(3), 164–175. https://doi.org/10.1016/s1053-4296(98)80042-8
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  - Hobbs, S. K., Monsky, W. L., Yuan, F., Roberts, W. G., Griffith, L., Torchilin, V. P., & Jain, R. K. (1998). Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment. Proceedings of the National Academy of Sciences of the United States of America, 95(8), 4607–4612. https://doi.org/10.1073/pnas.95.8.4607
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  - Monsky, W. L., Hobbs, S. K., Yuan, F., Torchilin, V. P., & Jain, R. K. (1998). Modulation of intratumoral drug delivery by the tumor microenvironment and vascular endothelial growth factor. Proceedings of the Controlled Release Society, (25), 207–208.
  - Jain, R. K., Schlenger, K., Höckel, M., & Yuan, F. (1997). Quantitative angiogenesis assays: progress and problems. Nature Medicine, 3(11), 1203–1208. https://doi.org/10.1038/nm1197-1203
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  - Fukumura, D., Yuan, F., Monsky, W. L., Chen, Y., & Jain, R. K. (1997). Effect of host microenvironment on the microcirculation of human colon adenocarcinoma. The American Journal of Pathology, 151(3), 679–688.
  - Nozue, M., Lee, I., Yuan, F., Teicher, B. A., Brizel, D. M., Dewhirst, M. W., … Suit, H. D. (1997). Interlaboratory variation in oxygen tension measurement by Eppendorf "Histograph" and comparison with hypoxic marker. J Surg Oncol, 66(1), 30–38. https://doi.org/10.1002/(sici)1096-9098(199709)66:1<30::aid-jso7>3.0.co;2-o
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  - Yuan, F. (1997). Stress is good and bad for tumors. Nature Biotechnology, 15(8), 722–723. https://doi.org/10.1038/nbt0897-722
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  - Berk, D. A., Yuan, F., Leunig, M., & Jain, R. K. (1997). Direct in vivo measurement of targeted binding in a human tumor xenograft. Proceedings of the National Academy of Sciences of the United States of America, 94(5), 1785–1790. https://doi.org/10.1073/pnas.94.5.1785
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  - Fukumura, D., Yuan, F., Endo, M., & Jain, R. K. (1997). Role of nitric oxide in tumor microcirculation. Blood flow, vascular permeability, and leukocyte-endothelial interactions. The American Journal of Pathology, 150(2), 713–725.
  - Helmlinger, G., Yuan, F., Dellian, M., & Jain, R. K. (1997). Interstitial pH and pO2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlation. Nature Medicine, 3(2), 177–182. https://doi.org/10.1038/nm0297-177
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  - Leunig, M., Yuan, F., Gerweck, L. E., & Jain, R. K. (1997). Effect of basic fibroblast growth factor on angiogenesis and growth of isografted bone: quantitative in vitro-in vivo analysis in mice. International Journal of Microcirculation, Clinical and Experimental, 17(1), 1–9. https://doi.org/10.1159/000179199
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  - Lichtenbeld, H. C., Yuan, F., Michel, C. C., & Jain, R. K. (1996). Perfusion of single tumor microvessels: application to vascular permeability measurement. Microcirculation (New York, N.Y. : 1994), 3(4), 349–357. https://doi.org/10.3109/10739689609148307
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  - Yuan, F., Chen, Y., Dellian, M., Safabakhsh, N., Ferrara, N., & Jain, R. K. (1996). Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody. Proceedings of the National Academy of Sciences of the United States of America, 93(25), 14765–14770. https://doi.org/10.1073/pnas.93.25.14765
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  - Dellian, M., Helmlinger, G., Yuan, F., & Jain, R. K. (1996). Fluorescence ratio imaging of interstitial pH in solid tumours: effect of glucose on spatial and temporal gradients. British Journal of Cancer, 74(8), 1206–1215. https://doi.org/10.1038/bjc.1996.518
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  - Leunig, M., Yuan, F., Berk, D. A., Gerweck, L. E., & Jain, R. K. (1996). Heating or freezing bone. Effects on angiogenesis induction and growth potential in mice. Acta Orthopaedica Scandinavica, 67(4), 383–388. https://doi.org/10.3109/17453679609002336
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  - Dellian, M., Witwer, B. P., Salehi, H. A., Yuan, F., & Jain, R. K. (1996). Quantitation and physiological characterization of angiogenic vessels in mice: effect of basic fibroblast growth factor, vascular endothelial growth factor/vascular permeability factor, and host microenvironment. The American Journal of Pathology, 149(1), 59–71.
  - Yamada, S., Mayadas, T. N., Yuan, F., Wagner, D. D., Hynes, R. O., Melder, R. J., & Jain, R. K. (1995). Rolling in P-selectin-deficient mice is reduced but not eliminated in the dorsal skin. Blood, 86(9), 3487–3492.
  - Yuan, F., Dellian, M., Fukumura, D., Leunig, M., Berk, D. A., Torchilin, V. P., & Jain, R. K. (1995). Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size. Cancer Research, 55(17), 3752–3756.
  - Leunig, M., Yuan, F., Gerweck, L. E., Berk, D. A., & Jain, R. K. (1995). Quantitative analysis of angiogenesis and growth of bone: effect of indomethacin exposure in a combined in vitro-in vivo approach. Research in Experimental Medicine. Zeitschrift Fur Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie, 195(5), 275–288. https://doi.org/10.1007/bf02576798
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  - Leu, A. J., Berk, D. A., Yuan, F., & Jain, R. K. (1994). Flow velocity in the superficial lymphatic network of the mouse tail. The American Journal of Physiology, 267(4 Pt 2), H1507–H1513. https://doi.org/10.1152/ajpheart.1994.267.4.h1507
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  - Yuan, F., Salehi, H. A., Boucher, Y., Vasthare, U. S., Tuma, R. F., & Jain, R. K. (1994). Vascular permeability and microcirculation of gliomas and mammary carcinomas transplanted in rat and mouse cranial windows. Cancer Research, 54(17), 4564–4568.
  - Leunig, M., Yuan, F., Berk, D. A., Gerweck, L. E., & Jain, R. K. (1994). Angiogenesis and growth of isografted bone: quantitative in vivo assay in nude mice. Laboratory Investigation; a Journal of Technical Methods and Pathology, 71(2), 300–307.
  - Yuan, F., Leunig, M., Huang, S. K., Berk, D. A., Papahadjopoulos, D., & Jain, R. K. (1994). Microvascular permeability and interstitial penetration of sterically stabilized (stealth) liposomes in a human tumor xenograft. Cancer Research, 54(13), 3352–3356.
  - Torres Filho, I. P., Leunig, M., Yuan, F., Intaglietta, M., & Jain, R. K. (1994). Noninvasive measurement of microvascular and interstitial oxygen profiles in a human tumor in SCID mice. Proceedings of the National Academy of Sciences of the United States of America, 91(6), 2081–2085. https://doi.org/10.1073/pnas.91.6.2081
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  - Berk, D. A., Yuan, F., Leunig, M., & Jain, R. K. (1993). Fluorescence photobleaching with spatial Fourier analysis: measurement of diffusion in light-scattering media. Biophysical Journal, 65(6), 2428–2436. https://doi.org/10.1016/s0006-3495(93)81326-2
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  - Yuan, F., Leunig, M., Berk, D. A., & Jain, R. K. (1993). Microvascular permeability of albumin, vascular surface area, and vascular volume measured in human adenocarcinoma LS174T using dorsal chamber in SCID mice. Microvascular Research, 45(3), 269–289. https://doi.org/10.1006/mvre.1993.1024
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  - Leunig, M., Yuan, F., Menger, M. D., Boucher, Y., Goetz, A. E., Messmer, K., & Jain, R. K. (1992). Angiogenesis, microvascular architecture, microhemodynamics, and interstitial fluid pressure during early growth of human adenocarcinoma LS174T in SCID mice. Cancer Research, 52(23), 6553–6560.
  - Baxter, L. T., Yuan, F., & Jain, R. K. (1992). Pharmacokinetic analysis of the perivascular distribution of bifunctional antibodies and haptens: comparison with experimental data. Cancer Research, 52(20), 5838–5844.
  - Yuan, F., Chien, S., & Weinbaum, S. (1991). A new view of convective-diffusive transport processes in the arterial intima. Journal of Biomechanical Engineering, 113(3), 314–329. https://doi.org/10.1115/1.2894890
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  - Yuan, F., Baxter, L. T., & Jain, R. K. (1991). Pharmacokinetic analysis of two-step approaches using bifunctional and enzyme-conjugated antibodies. Cancer Research, 51(12), 3119–3130.
  - Yuan, F., Weinbaum, S., Pfeffer, R., & Chien, S. (1991). A mathematical model for the receptor mediated cellular regulation of the low density lipoprotein metabolism. Journal of Biomechanical Engineering, 113(1), 1–10. https://doi.org/10.1115/1.2894079
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  - Yuan, F., Chien, S., & Weinbaum, S. (1990). New view of convective-diffusive processes in the arterial intima. American Society of Mechanical Engineers, Bioengineering Division (Publication) Bed, 17, 33–35.
  - Fan, Y., & Wang-yi, W. (1989). The displacement wave theory of blood vessel. Applied Mathematics and Mechanics, 10(6), 487–493. https://doi.org/10.1007/bf02017892
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- Book Sections
  - Yuan, F. (2018). Physiological Barriers to Drug Transport. In Molecular, Cellular, and Tissue Engineering (pp. 83-1-83–19).
- Conference Papers
  - Wang, C., Chang, C.-C., & Yuan, F. (2020). Inhibition of Caspase-3 Improves Electrotransfer Efficiency and Cell Viability. In Molecular Therapy (Vol. 28, pp. 473–473).
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  - Kaakati, R., Chang, C., Li, F., Liu, X., Yuan, F., & Li, C. (2018). 1213 Exosome-mediated RNAi delivery for melanoma therapy. In Journal of Investigative Dermatology (Vol. 138, pp. S206–S206). Elsevier BV. https://doi.org/10.1016/j.jid.2018.03.1228
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  - Cervia, L. D., Chang, C.-C., Wang, L., Mao, M., & Yuan, F. (2018). Enhancing Electrotransfection Efficiency Through Improvement in Nuclear Entry of Plasmid DNA. In Biophysical Journal (Vol. 114, pp. 542A-542A). San Francisco, CA: CELL PRESS.
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  - Cervia, L. D., Chang, C.-C., Wang, L., & Yuan, F. (2017). Distinct Effects of Endosomal Escape and Endosomal Trafficking on Gene Delivery via Electrotransfection. In Biophysical Journal (Vol. 112, pp. 473a-473a). Elsevier BV. https://doi.org/10.1016/j.bpj.2016.11.2539
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  - Cervia, L. D., Wang, L., Chang, C., Mao, M., & Yuan, F. (2017). Nuclear Envelope As A Physical Barrier In Electrotransfection. In Molecular Biology of the Cell (Vol. 28). Philadelphia, PA: AMER SOC CELL BIOLOGY.
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  - Liang, J., Yuan, F., Gonzalez, P., & Stamer, W. (2015). Signaling Pathways that mediate endoMT of Human Trabecular meshwork cells exposed to Cyclic Mechanical Stress. In Investigative Ophthalmology & Visual Science (Vol. 56). Denver, CO: ASSOC RESEARCH VISION OPHTHALMOLOGY INC.
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  - Liang, J., Navarro, I. D., Gonzalez, P., Yuan, F., & Stamer, W. D. (2014). Mechanical and cytokine stimulation of smooth muscle actin expression in human trabecular meshwork cells. In Investigative Ophthalmology & Visual Science (Vol. 55). ASSOC RESEARCH VISION OPHTHALMOLOGY INC.
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  - Camras, L., Stamer, W. D., Epstein, D., Gonzalez, P., & Yuan, F. (2013). Circumferential Trabecular Meshwork Stiffness in Glaucomatous Eyes. In Investigative Ophthalmology & Visual Science (Vol. 54). ASSOC RESEARCH VISION OPHTHALMOLOGY INC.
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  - Yuan, F., & Camras, L. (2013). Local Stiffness of Rat Trabecular Meshwork. In Investigative Ophthalmology & Visual Science (Vol. 54). ASSOC RESEARCH VISION OPHTHALMOLOGY INC.
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  - Needham, D., Wright, A., Tong, J., Dewhirst, M. W., Ponce, A., & Yuan, F. (2006). Mapping engineering onto biology at the nanoscale: nature's encapsulation technologies as bioinspiration for nano-scale anti-tumor drug delivery. In Nanomedicine: Nanotechnology, Biology and Medicine (Vol. 2, pp. 292–293). Elsevier BV. https://doi.org/10.1016/j.nano.2006.10.077
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  - McGuire, S., Zaharoff, D., & Yuan, F. (2006). Effects of tumor tissue collagen content on the flow rate during intratumoral infusion. In Cancer Research (Vol. 66). AMER ASSOC CANCER RESEARCH.
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  - Olbrich, K. C., & Yuan, F. (2004). Simulation of angiogenesis in engineered tissues: Effects of VEGF binding to matrix components. In Faseb Journal (Vol. 18, pp. A372–A372). Washington, DC: FEDERATION AMER SOC EXP BIOL.
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  - Zaharoff, D. A., & Yuan, F. (2003). Transmembrane transport of marker molecules and cell membrane kinetics during electropermeabilization. In Molecular Therapy (Vol. 7, pp. S64–S64). WASHINGTON, D.C.: ACADEMIC PRESS INC ELSEVIER SCIENCE.
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  - Olbrich, K. C., Tong, S., & Yuan, F. (2003). Simulation modeling of angiogenesis in engineered tissues: effects of growth factor supplementation. In Faseb Journal (Vol. 17, pp. A147–A147). SAN DIEGO, CALIFORNIA: FEDERATION AMER SOC EXP BIOL.
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  - Lockhart, A. C., Braun, R. D., Dewhirst, M. W., Humphrey, J. S., Yuan, F., Grichnick, J., … Hurwitz, H. I. (2000). Wound angiogenesis inhibition as a marker for anti-angiogenic efficacy. In Faseb Journal (Vol. 14, pp. A35–A35). FEDERATION AMER SOC EXP BIOL.
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  - Yuan, F., Zaharoff, D., Zhang, X. Y., Lohr, F., Dewhirst, M. W., & Li, C. Y. (2000). Delivery of plasmid DNA through intratumoral infusion and electroporation. In Asme International Mechanical Engineering Congress and Exposition, Proceedings (Imece) (Vol. 2000-F, pp. 125–128). https://doi.org/10.1115/IMECE2000-2231
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  - Yuan, F., Zhang, X., Dewhirst, M. W., & Luck, J. A. (1999). Pressure and temperature-dependence of the hydraulic conductivity in a fibrosarcoma. In Annual International Conference of the Ieee Engineering in Medicine and Biology Proceedings (Vol. 1, p. 91).
  - Jain, R. K., Baxter, L. T., Boucher, Y., Leunig, M., & Yuan, F. (1992). Transport of fluid and macromolecules in tumors. In American Society of Mechanical Engineers, Heat Transfer Division, (Publication) Htd (Vol. 231, pp. 103–104).
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